Saved BNGL Diagrams

Molecules

vegf(r,r,nrp1bd,c~s~i~i2~r)

vegfr2(l1,Y1175~Y~pY,CD47bd,dimer,c~s~i~i2~r)

vegfr1(l2,dimer,nrp1bd,c~s)

NRP1(vegfabd,c~s~i~i2~r)

PI(PIsite~3P~4P)

PLCgamma(Yplc~Y~pY)

DAG(pkcbd)

IP3_cyto(ip3rbd)

Calcium_cyto(bd)

Trash()

CaER(bd)

CaF(cabd)

CSQNF(cabd)

CaM(NCaM,NCaM,CCaM,CCaM,CaMtargetbd)

I()

Istim()

PTEN(PIP3docking)

TSADSrc(Y1~Y~pY)

Axl(Ysrc~Y~pY,Yaxl~Y~pY)

PI3K(state~active~inactive)

AKT(PHakt,T308~S~pS,S473~S~pS)

PDK1(PHpdk1,aktbd)

mTOR(aktbd)

CD47SIRPa(VEGFR2bd,TSP1bd,Y1~Y~pY,c~s~i~i2~r)

TSP1(CD47bd)

eNOS(CaMBD,S1177~S~pS,cav1BD)

caveolin1(eNOSbd)

PKC(CalciumBD,DAGBD)

CIB1(EF1,EF2,sk1bd,location~cytosol~membrane)

SphK(CIB1bd,Serk~S~pS)

Sph(skbd)

S1P(bd)

RasGDP(rafbd)

RasGTP(rafbd)

Raf(mekbd,rasbd,Y1Y2~Y~pY,Spkc~S~pS)

MEK12(bd,S1~S~pS,S2~S~pS)

ERK1(MEK12bd,S1~S~pS)

ERK2(MEK12bd,S2~S~pS)

Species

vegf(r,r,nrp1bd,c~s)

vegfr1(l2,dimer,nrp1bd,c~s)

vegfr2(l1,Y1175~Y,CD47bd,dimer,c~s)

NRP1(vegfabd,c~s)

PI(PIsite~3P)

PLCgamma(Yplc~Y)

CaER(bd)

Calcium_cyto(bd)

CaF(cabd)

Calcium_cyto(bd!1).CaF(cabd!1)

CaM(NCaM,NCaM,CCaM,CCaM,CaMtargetbd)

I()

Istim()

PTEN(PIP3docking)

TSADSrc(Y1~Y)

Axl(Ysrc~Y,Yaxl~Y)

PI3K(state~inactive)

AKT(PHakt,T308~S,S473~S)

PDK1(PHpdk1,aktbd)

mTOR(aktbd)

TSP1(CD47bd)

CD47SIRPa(VEGFR2bd,TSP1bd,Y1~Y,c~s)

eNOS(CaMBD,S1177~S,cav1BD!1).caveolin1(eNOSbd!1)

PKC(CalciumBD,DAGBD)

CIB1(EF1,EF2,sk1bd,location~cytosol)

SphK(CIB1bd,Serk~S)

Sph(skbd)

S1P(bd)

RasGDP(rafbd)

RasGTP(rafbd)

Raf(mekbd,rasbd,Y1Y2~Y,Spkc~S)

MEK12(bd,S1~S,S2~S)

ERK1(MEK12bd,S1~S)

ERK2(MEK12bd,S2~S)

Observables

vegffrees vegf(r,r,nrp1bd,c~s)

VEGFR2total vegfr2()

tsp1frees TSP1(CD47bd)

cd47tsp1s TSP1(CD47bd!1).CD47SIRPa(TSP1bd!1,Y1~Y,c~s)

cd47s CD47SIRPa(TSP1bd,Y1~Y,c~s)

VEGFR2tots vegfr2(c~s)

VEGFR2toti vegfr2(c~i)

vr2s vegfr2(l1,c~s)

vr2i vegfr2(l1,c~i)

vr1s vegfr1(l2,nrp1bd,c~s)

vegfr2Y1175ps vegfr2(Y1175~pY!?,c~s)

vegfr2Y1175pi vegfr2(Y1175~pY!?,c~i)

pr2Y1175total vegfr2(Y1175~pY!?)

vegfr1tots vegfr1(c~s)

NRP1VEGFR2s vegf(r!1,r!2,nrp1bd!+,c~s).vegfr2(l1!1,c~s).vegfr2(l1!2,c~s)

NRP1VEGFR2i vegf(r!1,r!2,nrp1bd!+,c~i).vegfr2(l1!1,c~i).vegfr2(l1!2,c~i)

freeDAGs DAG(pkcbd!?)

activePLCgamma PLCgamma(Yplc~pY!?)

PIP2 PI(PIsite~3P)

PIP3 PI(PIsite~4P)

freeip3cyto IP3_cyto(ip3rbd)

Cac Calcium_cyto(bd)

Caer CaER(bd)

CaBuf_fer CaF(cabd!+)

activePKCs PKC(CalciumBD!+,DAGBD!1).DAG(pkcbd!1)

activePKCtot PKC(CalciumBD!+,DAGBD!+)

SphKpkc SphK(Serk~pS!?)

S1phosphate S1P(bd)

NRP1frees NRP1(vegfabd,c~s)

NRP1freei NRP1(vegfabd,c~i)

NRP1bounds NRP1(vegfabd!+,c~s)

NRP1boundi NRP1(vegfabd!+,c~i)

vr2dimers vegfr2(l1,dimer!1,c~s).vegfr2(l1,dimer!1,c~s)

vr2dimeri vegfr2(l1,dimer!1,c~i).vegfr2(l1,dimer!1,c~i)

NRP1totals NRP1(c~s)

NRP1totali NRP1(c~i)

singleNRP1totals NRP1(vegfabd,c~s)

singleNRP1totali NRP1(vegfabd,c~i)

vegfr2total vegf(r!1).vegfr2(l1!1)

vr2Y1175s vegfr2(Y1175~pY,c~s)

vr2Y1175i vegfr2(Y1175~pY,c~i)

plcgammafree PLCgamma(Yplc~Y)

rasgdpfree RasGDP(rafbd!?)

rasgtpfree RasGTP(rafbd!?)

activeRafbyrastot Raf(Y1Y2~pY!?)

phosphoMEK12tot MEK12(S1~pS!?,S2~pS!?)

phosphoERK1tot ERK1(S1~pS!?)

phosphoERK2tot ERK2(S2~pS!?)

SphK1 SphK(CIB1bd!+,Serk~S).CIB1(sk1bd!1,location~membrane)

SphK1mempS SphK(CIB1bd!+,Serk~pS).CIB1(sk1bd!1,location~membrane)

SphK1cytosol SphK(CIB1bd!+,Serk~S).CIB1(sk1bd!1,location~cytosol)

activeSphK1 SphK(Serk~pS!?)

freeSK1 SphK(CIB1bd,Serk~S)

freeSK1mem SphK(CIB1bd!1,Serk~S).CIB1(sk1bd!1,location~membrane)

freecib1 CIB1(EF1,EF2,sk1bd)

calciumcib1 CIB1(EF1!+,EF2!+,sk1bd)

sk1bcib1 CIB1(EF1!+,EF2!+,sk1bd!+)

nrp1s NRP1(vegfabd,c~s)

vegfnrp1s vegf(r,r,nrp1bd!1,c~s).NRP1(vegfabd!1,c~s)

vegfr1s vegf(r!1,r,nrp1bd,c~s).vegfr1(l2!1,c~s)

vegfr2s vegf(r!1,r,nrp1bd,c~s).vegfr2(l1!1,dimer,c~s)

freepip2 PI(PIsite~3P)

freesphingosin Sph(skbd)

freeraf Raf(Spkc~S)

activeRafPKC Raf(Spkc~pS!?)

activeRafPKCERK1 Raf(Spkc~pS!?,Y1Y2~pY!?)

activeRafPKCERK2 Raf(Spkc~pS!?,Y1Y2~Y!?)

activeRafPKCERK3 Raf(Spkc~S!?,Y1Y2~pY!?)

rafY1Y2pY Raf(Y1Y2~pY,Spkc~S)

rafY1Y2pYpS Raf(Y1Y2~pY,Spkc~pS)

rafpS Raf(Y1Y2~Y,Spkc~pS)

erk1s ERK1(S1~S)

mek12s MEK12(S1~S,S2~S)

R2singlei vegfr2(l1,Y1175~Y,dimer,c~i)

pERK1s ERK1(S1~pS)

mek12ps MEK12(S1~pS,S2~S)

pERK2s ERK2(S2~pS)

mek12ps1 MEK12(S1~pS)

mek12ps2 MEK12(S2~pS)

erk1ps ERK1(S1~pS)

erk2ps ERK2(S2~pS)

vr2r2py1175s vegfr2(Y1175~pY,c~s)

vr2r2py1175i vegfr2(Y1175~pY,c~i)

vr2py1175s vegf(r!1,r,c~s).vegfr2(l1!1,Y1175~pY,c~s)

vr2py1175i vegf(r!1,r,c~i).vegfr2(l1!1,Y1175~pY,c~i)

r2singlepy1175s vegfr2(l1,Y1175~pY,c~s)

r2singlepy1175i vegfr2(l1,Y1175~pY,c~i)

vr1r2pY1165s vegf(r!1,r!2,c~s).vegfr1(l2!1,c~s).vegfr2(l1!2,Y1175~pY,c~s)

pSK1 SphK(Serk~pS)

frees1p S1P(bd)

py1y2rafs Raf(Y1Y2~pY)

vegfnrp1i vegf(r,r,nrp1bd!1,c~i).NRP1(vegfabd!1,c~i)

vegfr2i vegf(r!1,r,nrp1bd,c~i).vegfr2(l1!1,c~i)

totalnrp1 NRP1(vegfabd)

pplcgamma PLCgamma(Yplc~pY)

phosphoERKpS1 ERK1(S1~pS!?)

phosphoERKpS2 ERK2(S2~pS!?)

phosphoMEKpS1 MEK12(S1~pS!?,S2~S)

phosphoMEKpS2 MEK12(S1~S,S2~pS!?)

freeSphK1 SphK(CIB1bd,Serk~S)

rafpkc Raf(Spkc~pS)

mek12s1 MEK12(S1~S)

mek12s2 MEK12(S2~S)

erk12s1 ERK1(S1~S)

erk12s2 ERK2(S2~S)

yplcgamma PLCgamma(Yplc~Y)

gtpfreeras RasGTP(rafbd)

bvegfr2 vegf(r!1,nrp1bd,c~s).vegfr2(l1!1,c~s)

bnrp1 vegf(nrp1bd!1,c~s).NRP1(vegfabd!1,c~s)

bvegfr1 vegf(r!1,nrp1bd,c~s).vegfr1(l2!1,c~s)

bvegfr1dimer vegf(r!1,r!2,c~s).vegfr1(l2!1,c~s).vegfr1(l2!2,c~s)

bvegfr2_2 vegf(r!1,c~s).vegfr2(l1!1,c~s)

bvegfr1_2 vegf(r!1,c~s).vegfr1(l2!1,c~s)

vegfbound_1 vegf(r!+,nrp1bd,c~s)

vegfbound_2 vegf(r,nrp1bd!+,c~s)

vegfbound_3 vegf(r!+,c~s)

vegfbound_4 vegf(r,r,nrp1bd!1,c~s).NRP1(vegfabd!1,c~s)

Iopenstim Istim()

nrp1r1s NRP1(vegfabd!1,c~s).vegfr1(nrp1bd!1,c~s)

CIB1mem CIB1(location~membrane)

freepip3 PI(PIsite~4P)

ps473akt AKT(S473~pS)

ps308akt AKT(T308~pS)

phosphoAxltotal Axl(Ysrc~pY!?,Yaxl~pY!?)

phosphoAxlpSrc Axl(Ysrc~pY!?)

phosphoAxlpauto Axl(Yaxl~pY!?)

activeSrc TSADSrc(Y1~pY!?)

phosphoeNOS eNOS(S1177~pS)

ppAkt AKT(S473~pS,T308~pS)

Reaction Rules

Ligand-independent coupling of the receptors

vegfr2(l1,dimer,c~s) + vegfr2(l1,dimer,c~s) <-> vegfr2(l1,dimer!1,c~s).vegfr2(l1,dimer!1,c~s)

vegfr2(l1,dimer,c~s) + vegfr1(l2,dimer,c~s) <-> vegfr2(l1,dimer!1,c~s).vegfr1(l2,dimer!1,c~s)

vegfr1(l2,dimer,c~s) + vegfr1(l2,dimer,c~s) <-> vegfr1(l2,dimer!1,c~s).vegfr1(l2,dimer!1,c~s)

vegf(r!1,r!2,c~s).vegfr2(l1!1,dimer,c~s).vegfr2(l1!2,dimer,c~s) <-> vegf(r!1,r!2,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr2(l1!2,dimer!3,c~s)

vegf(r!1,r!2,c~s).vegfr2(l1!1,dimer,c~s).vegfr1(l2!2,dimer,c~s) <-> vegf(r!1,r!2,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s)

vegf(r!1,r!2,c~s).vegfr1(l2!1,dimer,c~s).vegfr1(l2!2,dimer,c~s) <-> vegf(r!1,r!2,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s)

VEGFR1 binding to NRP1

vegfr1(nrp1bd,c~s) + NRP1(vegfabd,c~s) <-> vegfr1(nrp1bd!1,c~s).NRP1(vegfabd!1,c~s)

Binding of VEGF165a to NRP1

I() -> I() + vegf(r,r,nrp1bd,c~s)

vegf(r,r,nrp1bd,c~s) + NRP1(vegfabd,c~s) -> vegf(r,r,nrp1bd,c~s) + vegf(r,r,nrp1bd!1,c~s).NRP1(vegfabd!1,c~s)

vegf(r,r,nrp1bd!1,c~s).NRP1(vegfabd!1,c~s) -> NRP1(vegfabd,c~s)

vegf(r,r,nrp1bd!+,c~s) + vegfr2(l1,dimer,c~s) <-> vegf(r!2,r,nrp1bd!+,c~s).vegfr2(l1!2,dimer,c~s)

vegf(r,r,nrp1bd!+,c~s) + vegfr2(l1,dimer!3,c~s).vegfr2(l1,dimer!3,c~s) <-> vegf(r!2,r,nrp1bd!+,c~s).vegfr2(l1!2,dimer!3,c~s).vegfr2(l1,dimer!3,c~s)

vegf(r,r,nrp1bd!+,c~s) + vegfr2(l1,dimer!3,c~s).vegfr1(l2,dimer!3,c~s) <-> vegf(r!2,r,nrp1bd!+,c~s).vegfr2(l1!2,dimer!3,c~s).vegfr1(l2,dimer!3,c~s)

vegf(r,r,nrp1bd!+,c~s) + vegfr1(l2,dimer,c~s) <-> vegf(r!2,r,nrp1bd!+,c~s).vegfr1(l2!2,dimer,c~s)

vegf(r,r,nrp1bd!+,c~s) + vegfr1(l2,dimer!3,c~s).vegfr1(l2,dimer!3,c~s) <-> vegf(r!2,r,nrp1bd!+,c~s).vegfr1(l2!2,dimer!3,c~s).vegfr1(l2,dimer!3,c~s)

vegf(r,r,nrp1bd!+,c~s) + vegfr1(l2,dimer!3,c~s).vegfr2(l1,dimer!3,c~s) <-> vegf(r!2,r,nrp1bd!+,c~s).vegfr1(l2!2,dimer!3,c~s).vegfr2(l1,dimer!3,c~s)

Binding of VEGF165a to VEGFR2 receptors

I() -> I() + vegf(r,r,nrp1bd,c~s)

vegf(r,r,nrp1bd,c~s) + vegfr2(l1,c~s) -> vegf(r,r,nrp1bd,c~s) + vegf(r!1,r,nrp1bd,c~s).vegfr2(l1!1,c~s)

vegf(r!1,r,nrp1bd,c~s).vegfr2(l1!1,c~s) -> vegfr2(l1,c~s)

vegf(r!1,r,nrp1bd,c~s).vegfr2(l1!1,dimer,c~s) + vegfr2(l1,dimer,c~s) <-> vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,dimer,c~s).vegfr2(l1!2,dimer,c~s)

vegf(r!1,r,nrp1bd,c~s).vegfr2(l1!1,dimer,c~s) + vegfr1(l2,dimer,c~s) <-> vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,dimer,c~s).vegfr1(l2!2,dimer,c~s)

vegf(r!1,r,nrp1bd,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr2(l1,dimer!3,c~s) <-> vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr2(l1!2,dimer!3,c~s)

vegf(r!1,r,nrp1bd,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr1(l2,dimer!3,c~s) <-> vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s)

vegf(r!1,r,nrp1bd,c~s).vegfr1(l2!1,dimer,c~s) + vegfr1(l2,dimer,c~s) <-> vegf(r!1,r!2,nrp1bd,c~s).vegfr1(l2!1,dimer,c~s).vegfr1(l2!2,dimer,c~s)

vegf(r!1,r,nrp1bd,c~s).vegfr1(l2!1,dimer,c~s) + vegfr2(l1,dimer,c~s) <-> vegf(r!1,r!2,nrp1bd,c~s).vegfr1(l2!1,dimer,c~s).vegfr2(l1!2,dimer,c~s)

vegf(r!1,r,nrp1bd,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr1(l2,dimer!3,c~s) <-> vegf(r!1,r!2,nrp1bd,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s)

vegf(r!1,r,nrp1bd,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr2(l1,dimer!3,c~s) <-> vegf(r!1,r!2,nrp1bd,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr2(l1!2,dimer!3,c~s)

vegf(r!1,r,nrp1bd!+,c~s).vegfr2(l1!1,dimer,c~s) + vegfr2(l1,dimer,c~s) <-> vegf(r!1,r!2,nrp1bd!+,c~s).vegfr2(l1!1,dimer,c~s).vegfr2(l1!2,dimer,c~s)

vegf(r!1,r,nrp1bd!+,c~s).vegfr2(l1!1,dimer,c~s) + vegfr1(l2,dimer,c~s) <-> vegf(r!1,r!2,nrp1bd!+,c~s).vegfr2(l1!1,dimer,c~s).vegfr1(l2!2,dimer,c~s)

vegf(r!1,r,nrp1bd!+,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr2(l1,dimer!3,c~s) <-> vegf(r!1,r!2,nrp1bd!+,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr2(l1!2,dimer!3,c~s)

vegf(r!1,r,nrp1bd!+,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr1(l2,dimer!3,c~s) <-> vegf(r!1,r!2,nrp1bd!+,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s)

vegf(r!1,r,nrp1bd!+,c~s).vegfr1(l2!1,dimer,c~s) + vegfr1(l2,dimer,c~s) <-> vegf(r!1,r!2,nrp1bd!+,c~s).vegfr1(l2!1,dimer,c~s).vegfr1(l2!2,dimer,c~s)

vegf(r!1,r,nrp1bd!+,c~s).vegfr1(l2!1,dimer,c~s) + vegfr2(l1,dimer,c~s) <-> vegf(r!1,r!2,nrp1bd!+,c~s).vegfr1(l2!1,dimer,c~s).vegfr2(l1!2,dimer,c~s)

vegf(r!1,r,nrp1bd!+,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr1(l2,dimer!3,c~s) <-> vegf(r!1,r!2,nrp1bd!+,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s)

vegf(r!1,r,nrp1bd!+,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr2(l1,dimer!3,c~s) <-> vegf(r!1,r!2,nrp1bd!+,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr2(l1!2,dimer!3,c~s)

vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr2(l1!2,dimer!3,c~s) + NRP1(vegfabd,c~s) <-> vegf(r!1,r!2,nrp1bd!4,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr2(l1!2,dimer!3,c~s).NRP1(vegfabd!4,c~s)

vegf(r!1,r!2,nrp1bd,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s) + NRP1(vegfabd,c~s) <-> vegf(r!1,r!2,nrp1bd!4,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s).NRP1(vegfabd!4,c~s)

vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s) + NRP1(vegfabd,c~s) <-> vegf(r!1,r!2,nrp1bd!4,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s).NRP1(vegfabd!4,c~s)

vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,dimer,c~s).vegfr2(l1!2,dimer,c~s) + NRP1(vegfabd,c~s) <-> vegf(r!1,r!2,nrp1bd!4,c~s).vegfr2(l1!1,dimer,c~s).vegfr2(l1!2,dimer,c~s).NRP1(vegfabd!4,c~s)

vegf(r!1,r,nrp1bd,c~s).vegfr2(l1!1,c~s) + NRP1(vegfabd,c~s) <-> vegf(r!1,r,nrp1bd!2,c~s).vegfr2(l1!1,c~s).NRP1(vegfabd!2,c~s)

vegf(r!1,r,nrp1bd,c~s).vegfr1(l2!1,c~s) + NRP1(vegfabd,c~s) <-> vegf(r!1,r,nrp1bd!2,c~s).vegfr1(l2!1,c~s).NRP1(vegfabd!2,c~s)

#######################
vegf165a binding to vegfr1

I() -> I() + vegf(r,r,nrp1bd,c~s)

vegf(r,r,nrp1bd,c~s) + vegfr1(l2,c~s) -> vegf(r,r,nrp1bd,c~s) + vegf(r!1,r,nrp1bd,c~s).vegfr1(l2!1,c~s)

vegf(r!1,r,nrp1bd,c~s).vegfr1(l2!1,c~s) -> vegfr1(l2,c~s)

vegf(r!1,r,c~s).vegfr1(l2!1,dimer,c~s) + vegfr1(l2,dimer,c~s) <-> vegf(r!1,r!2,c~s).vegfr1(l2!1,dimer,c~s).vegfr1(l2!2,dimer,c~s)

vegf(r!1,r,c~s).vegfr1(l2!1,dimer,c~s) + vegfr2(l1,dimer,c~s) <-> vegf(r!1,r!2,c~s).vegfr1(l2!1,dimer,c~s).vegfr2(l1!2,dimer,c~s)

vegf(r!1,r,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr1(l2,dimer!3,c~s) <-> vegf(r!1,r!2,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s)

vegf(r!1,r,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr2(l1,dimer!3,c~s) <-> vegf(r!1,r!2,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr2(l1!2,dimer!3,c~s)

################################
Receptor phosphorylation

vegf(r!1,r!2,c~s).vegfr2(l1!1,c~s).vegfr2(l1!2,Y1175~Y,c~s) -> vegf(r!1,r!2,c~s).vegfr2(l1!1,c~s).vegfr2(l1!2,Y1175~pY,c~s)

vegf(r!1,r!2,c~i).vegfr2(l1!1,c~i).vegfr2(l1!2,Y1175~Y,c~i) -> vegf(r!1,r!2,c~i).vegfr2(l1!1,c~i).vegfr2(l1!2,Y1175~pY,c~i)

vegf(r!1,r!2,c~i2).vegfr2(l1!1,c~i2).vegfr2(l1!2,Y1175~Y,c~i2) -> vegf(r!1,r!2,c~i2).vegfr2(l1!1,c~i2).vegfr2(l1!2,Y1175~pY,c~i2)

vegf(r!1,r!2,c~r).vegfr2(l1!1,c~r).vegfr2(l1!2,Y1175~Y,c~r) -> vegf(r!1,r!2,c~r).vegfr2(l1!1,c~r).vegfr2(l1!2,Y1175~pY,c~r)

Dephosphorylation of VEGFR2 species

vegfr2(Y1175~pY,CD47bd,c~s) -> vegfr2(Y1175~Y,CD47bd,c~s)

vegfr2(Y1175~pY,CD47bd!3,c~s).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~s) -> vegfr2(Y1175~Y,CD47bd!3,c~s).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~s)

vegfr2(Y1175~pY,CD47bd!3,c~s).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~s) -> vegfr2(Y1175~Y,CD47bd!3,c~s).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~s)

vegfr2(Y1175~pY,CD47bd,c~i) -> vegfr2(Y1175~Y,CD47bd,c~i)

vegfr2(Y1175~pY,CD47bd!3,c~i).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i) -> vegfr2(Y1175~Y,CD47bd!3,c~i).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i)

vegfr2(Y1175~pY,CD47bd!3,c~i).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i) -> vegfr2(Y1175~Y,CD47bd!3,c~i).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i)

vegfr2(Y1175~pY,CD47bd,c~i2) -> vegfr2(Y1175~Y,CD47bd,c~i2)

vegfr2(Y1175~pY,CD47bd!3,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i2) -> vegfr2(Y1175~Y,CD47bd!3,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i2)

vegfr2(Y1175~pY,CD47bd!3,c~i2).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i2) -> vegfr2(Y1175~Y,CD47bd!3,c~i2).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i2)

vegfr2(Y1175~pY,c~r) -> vegfr2(Y1175~Y,c~r)

Internalization s to i

vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,CD47bd,dimer,c~s).vegfr2(l1!2,CD47bd,dimer,c~s) -> vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd,dimer,c~i).vegfr2(l1!2,CD47bd,dimer,c~i)

vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,CD47bd,dimer!6,c~s).vegfr2(l1!2,CD47bd,dimer!6,c~s) -> vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd,dimer!6,c~i).vegfr2(l1!2,CD47bd,dimer!6,c~i)

vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,CD47bd!3,dimer,c~s).CD47SIRPa(VEGFR2bd!3,c~s).vegfr2(l1!2,CD47bd,dimer,c~s) -> vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd!3,dimer,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd,dimer,c~i)

vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,CD47bd!3,dimer!6,c~s).CD47SIRPa(VEGFR2bd!3,c~s).vegfr2(l1!2,CD47bd,dimer!6,c~s) -> vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd!3,dimer!6,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd,dimer!6,c~i)

vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,CD47bd!3,dimer,c~s).CD47SIRPa(VEGFR2bd!3,c~s).vegfr2(l1!2,CD47bd!4,dimer,c~s).CD47SIRPa(VEGFR2bd!4,c~s) -> vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd!3,dimer,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd!4,dimer,c~i).CD47SIRPa(VEGFR2bd!4,c~i)

vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,CD47bd!3,dimer!6,c~s).CD47SIRPa(VEGFR2bd!3,c~s).vegfr2(l1!2,CD47bd!4,dimer!6,c~s).CD47SIRPa(VEGFR2bd!4,c~s) -> vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd!3,dimer!6,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd!4,dimer!6,c~i).CD47SIRPa(VEGFR2bd!4,c~i)

vegf(r!1,r!2,nrp1bd!9,c~s).NRP1(vegfabd!9,c~s).vegfr2(l1!1,CD47bd,dimer,c~s).vegfr2(l1!2,CD47bd,dimer,c~s) -> vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd,dimer,c~i).vegfr2(l1!2,CD47bd,dimer,c~i)

vegf(r!1,r!2,nrp1bd!9,c~s).NRP1(vegfabd!9,c~s).vegfr2(l1!1,CD47bd!3,dimer,c~s).CD47SIRPa(VEGFR2bd!3,c~s).vegfr2(l1!2,CD47bd,dimer,c~s) -> vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd!3,dimer,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd,dimer,c~i)

vegf(r!1,r!2,nrp1bd!9,c~s).NRP1(vegfabd!9,c~s).vegfr2(l1!1,CD47bd!3,dimer,c~s).CD47SIRPa(VEGFR2bd!3,c~s).vegfr2(l1!2,CD47bd!4,dimer,c~s).CD47SIRPa(VEGFR2bd!4,c~s) -> vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd!3,dimer,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd!4,dimer,c~i).CD47SIRPa(VEGFR2bd!4,c~i)

vegf(r!1,r!2,nrp1bd!9,c~s).NRP1(vegfabd!9,c~s).vegfr2(l1!1,CD47bd,dimer!6,c~s).vegfr2(l1!2,CD47bd,dimer!6,c~s) -> vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd,dimer!6,c~i).vegfr2(l1!2,CD47bd,dimer!6,c~i)

vegf(r!1,r!2,nrp1bd!9,c~s).NRP1(vegfabd!9,c~s).vegfr2(l1!1,CD47bd!3,dimer!6,c~s).CD47SIRPa(VEGFR2bd!3,c~s).vegfr2(l1!2,CD47bd,dimer!6,c~s) -> vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd!3,dimer!6,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd,dimer!6,c~i)

vegf(r!1,r!2,nrp1bd!9,c~s).NRP1(vegfabd!9,c~s).vegfr2(l1!1,CD47bd!3,dimer!6,c~s).CD47SIRPa(VEGFR2bd!3,c~s).vegfr2(l1!2,CD47bd!4,dimer!6,c~s).CD47SIRPa(VEGFR2bd!4,c~s) -> vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd!3,dimer!6,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd!4,dimer!6,c~i).CD47SIRPa(VEGFR2bd!4,c~i)

From i to i2 compartment

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd,dimer,c~i).vegfr2(l1!2,CD47bd,dimer,c~i) <-> vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,CD47bd,dimer,c~i2).vegfr2(l1!2,CD47bd,dimer,c~i2)

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd,dimer!6,c~i).vegfr2(l1!2,CD47bd,dimer!6,c~i) <-> vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,CD47bd,dimer!6,c~i2).vegfr2(l1!2,CD47bd,dimer!6,c~i2)

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd!3,dimer,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd,dimer,c~i) <-> vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,CD47bd!3,dimer,c~i2).CD47SIRPa(VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd,dimer,c~i2)

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd!3,dimer!4,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd,dimer!4,c~i) <-> vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,CD47bd!3,dimer!4,c~i2).CD47SIRPa(VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd,dimer!4,c~i2)

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd!3,dimer,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd!4,dimer,c~i).CD47SIRPa(VEGFR2bd!4,c~i) <-> vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,CD47bd!3,dimer,c~i2).CD47SIRPa(VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd!4,dimer,c~i2).CD47SIRPa(VEGFR2bd!4,c~i2)

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd!3,dimer!6,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd!4,dimer!6,c~i).CD47SIRPa(VEGFR2bd!4,c~i) <-> vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,CD47bd!3,dimer!6,c~i2).CD47SIRPa(VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd!4,dimer!6,c~i2).CD47SIRPa(VEGFR2bd!4,c~i2)

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd,dimer,c~i).vegfr2(l1!2,CD47bd,dimer,c~i) <-> vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd,dimer,c~i2).vegfr2(l1!2,CD47bd,dimer,c~i2)

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd,dimer!6,c~i).vegfr2(l1!2,CD47bd,dimer!6,c~i) <-> vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd,dimer!6,c~i2).vegfr2(l1!2,CD47bd,dimer!6,c~i2)

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd!3,dimer,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd,dimer,c~i) <-> vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer,c~i2).CD47SIRPa(VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd,dimer,c~i2)

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd!3,dimer!6,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd,dimer!6,c~i) <-> vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer!6,c~i2).CD47SIRPa(VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd,dimer!6,c~i2)

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd!3,dimer,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd!4,dimer,c~i).CD47SIRPa(VEGFR2bd!4,c~i) <-> vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer,c~i2).CD47SIRPa(VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd!4,dimer,c~i2).CD47SIRPa(VEGFR2bd!4,c~i2)

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd!3,dimer!6,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd!4,dimer!6,c~i).CD47SIRPa(VEGFR2bd!4,c~i) <-> vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer!6,c~i2).CD47SIRPa(VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd!4,dimer!6,c~i2).CD47SIRPa(VEGFR2bd!4,c~i2)

From internalized compartment to the recycling compartment

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd,dimer,c~i2).vegfr2(l1!2,CD47bd,dimer,c~i2) -> vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,CD47bd,dimer,c~r).vegfr2(l1!2,CD47bd,dimer,c~r)

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd,dimer!6,c~i2).vegfr2(l1!2,CD47bd,dimer!6,c~i2) -> vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,CD47bd,dimer!6,c~r).vegfr2(l1!2,CD47bd,dimer!6,c~r)

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd,dimer,c~i2) -> vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,CD47bd!3,dimer,c~r).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~r).vegfr2(l1!2,CD47bd,dimer,c~r)

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer!6,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd,dimer!6,c~i2) -> vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,CD47bd!3,dimer!6,c~r).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~r).vegfr2(l1!2,CD47bd,dimer!6,c~r)

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd!4,dimer,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!4,c~i2) -> vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,CD47bd!3,dimer,c~r).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~r).vegfr2(l1!2,CD47bd!4,dimer,c~r).CD47SIRPa(TSP1bd,VEGFR2bd!4,c~r)

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer!6,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd!4,dimer!6,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!4,c~i2) -> vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,CD47bd!3,dimer!6,c~r).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~r).vegfr2(l1!2,CD47bd!4,dimer!6,c~r).CD47SIRPa(TSP1bd,VEGFR2bd!4,c~r)

####################################################################################################################################################################################################

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer,c~i2).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd,dimer,c~i2) -> vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,CD47bd!3,dimer,c~r).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~r).vegfr2(l1!2,CD47bd,dimer,c~r)

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer!6,c~i2).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd,dimer!6,c~i2) -> vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,CD47bd!3,dimer!6,c~r).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~r).vegfr2(l1!2,CD47bd,dimer!6,c~r)

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer,c~i2).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd!4,dimer,c~i2).CD47SIRPa(VEGFR2bd!4,c~i2) -> vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,CD47bd!3,dimer,c~r).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~r).vegfr2(l1!2,CD47bd!4,dimer,c~r).CD47SIRPa(VEGFR2bd!4,c~r)

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer!6,c~i2).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd!4,dimer!6,c~i2).CD47SIRPa(VEGFR2bd!4,c~i2) -> vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,CD47bd!3,dimer!6,c~r).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~r).vegfr2(l1!2,CD47bd!4,dimer!6,c~r).CD47SIRPa(VEGFR2bd!4,c~r)

#####################################################################################################################################################################################################
Recycling r to s

vegfr2(l1,Y1175~Y,CD47bd,dimer,c~r) -> vegfr2(l1,Y1175~Y,CD47bd,dimer,c~s)

NRP1(vegfabd,c~r) -> NRP1(vegfabd,c~s)

CD47SIRPa(TSP1bd,VEGFR2bd,c~r) -> CD47SIRPa(TSP1bd,VEGFR2bd,c~s)

vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,dimer,c~r).vegfr2(l1!2,dimer,c~r) -> NRP1(vegfabd,c~r) + vegfr2(l1,dimer,c~r) + vegfr2(l1,dimer,c~r)

vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,dimer!6,c~r).vegfr2(l1!2,dimer!6,c~r) -> NRP1(vegfabd,c~r) + vegfr2(l1,dimer!6,c~r).vegfr2(l1,dimer!6,c~r)

vegfr2(dimer!6,c~r).vegfr2(dimer!6,c~r) -> vegfr2(dimer,c~r) + vegfr2(dimer,c~r)

vegfr2(CD47bd!3,c~r).CD47SIRPa(VEGFR2bd!3,c~r) -> vegfr2(CD47bd,c~r) + CD47SIRPa(VEGFR2bd,c~r)

CD47SIRPa(TSP1bd!1,c~r).TSP1(CD47bd!1) -> CD47SIRPa(TSP1bd,c~r)

Receptor degradation

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,Y1175~pY,CD47bd,c~i).vegfr2(l1!2,CD47bd,c~i) -> Trash()

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,Y1175~Y,CD47bd,c~i).vegfr2(l1!2,Y1175~Y,CD47bd,c~i) -> Trash()

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,Y1175~pY,CD47bd!3,c~i).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd,c~i) -> Trash()

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,Y1175~Y,CD47bd!3,c~i).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i).vegfr2(l1!2,Y1175~Y,CD47bd,c~i) -> Trash()

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,Y1175~pY,CD47bd!3,c~i).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd!4,c~i).CD47SIRPa(TSP1bd,VEGFR2bd!4,c~i) -> Trash()

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,Y1175~Y,CD47bd!3,c~i).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i).vegfr2(l1!2,Y1175~Y,CD47bd!4,c~i).CD47SIRPa(TSP1bd,VEGFR2bd!4,c~i) -> Trash()

vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,Y1175~pY,CD47bd,c~i2).vegfr2(l1!2,CD47bd,c~i2) -> Trash()

vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,Y1175~Y,CD47bd,c~i2).vegfr2(l1!2,Y1175~Y,CD47bd,c~i2) -> Trash()

vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,Y1175~pY,CD47bd!3,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd,c~i2) -> Trash()

vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,Y1175~Y,CD47bd!3,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i2).vegfr2(l1!2,Y1175~Y,CD47bd,c~i2) -> Trash()

vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,Y1175~pY,CD47bd!3,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd!4,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!4,c~i2) -> Trash()

vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,Y1175~Y,CD47bd!3,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i2).vegfr2(l1!2,Y1175~Y,CD47bd!4,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!4,c~i2) -> Trash()

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,Y1175~pY,CD47bd,c~i).vegfr2(l1!2,CD47bd,c~i) -> Trash()

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,Y1175~Y,CD47bd,c~i).vegfr2(l1!2,Y1175~Y,CD47bd,c~i) -> Trash()

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,Y1175~pY,CD47bd!3,c~i).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd,c~i) -> Trash()

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,Y1175~Y,CD47bd!3,c~i).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i).vegfr2(l1!2,Y1175~Y,CD47bd,c~i) -> Trash()

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,Y1175~pY,CD47bd!3,c~i).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd!4,c~i).CD47SIRPa(TSP1bd,VEGFR2bd!4,c~i) -> Trash()

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,Y1175~Y,CD47bd!3,c~i).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i).vegfr2(l1!2,Y1175~Y,CD47bd!4,c~i).CD47SIRPa(TSP1bd,VEGFR2bd!4,c~i) -> Trash()

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,Y1175~pY,CD47bd,c~i2).vegfr2(l1!2,CD47bd,c~i2) -> Trash()

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,Y1175~Y,CD47bd,c~i2).vegfr2(l1!2,Y1175~Y,CD47bd,c~i2) -> Trash()

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,Y1175~pY,CD47bd!3,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd,c~i2) -> Trash()

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,Y1175~Y,CD47bd!3,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i2).vegfr2(l1!2,Y1175~Y,CD47bd,c~i2) -> Trash()

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,Y1175~pY,CD47bd!3,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd!4,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!4,c~i2) -> Trash()

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,Y1175~Y,CD47bd!3,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i2).vegfr2(l1!2,Y1175~Y,CD47bd!4,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!4,c~i2) -> Trash()

with TSP1

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,Y1175~pY,CD47bd!3,c~i).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd,c~i) -> Trash()

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,Y1175~Y,CD47bd!3,c~i).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i).vegfr2(l1!2,Y1175~Y,CD47bd,c~i) -> Trash()

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,Y1175~pY,CD47bd!3,c~i).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd!4,c~i).CD47SIRPa(VEGFR2bd!4,c~i) -> Trash()

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,Y1175~Y,CD47bd!3,c~i).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i).vegfr2(l1!2,Y1175~Y,CD47bd!4,c~i).CD47SIRPa(VEGFR2bd!4,c~i) -> Trash()

vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,Y1175~pY,CD47bd!3,c~i2).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd,c~i2) -> Trash()

vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,Y1175~Y,CD47bd!3,c~i2).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i2).vegfr2(l1!2,Y1175~Y,CD47bd,c~i2) -> Trash()

vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,Y1175~pY,CD47bd!3,c~i2).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd!4,c~i2).CD47SIRPa(VEGFR2bd!4,c~i2) -> Trash()

vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,Y1175~Y,CD47bd!3,c~i2).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i2).vegfr2(l1!2,Y1175~Y,CD47bd!4,c~i2).CD47SIRPa(VEGFR2bd!4,c~i2) -> Trash()

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,Y1175~pY,CD47bd!3,c~i).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd,c~i) -> Trash()

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,Y1175~Y,CD47bd!3,c~i).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i).vegfr2(l1!2,Y1175~Y,CD47bd,c~i) -> Trash()

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,Y1175~pY,CD47bd!3,c~i).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd!4,c~i).CD47SIRPa(VEGFR2bd!4,c~i) -> Trash()

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,Y1175~Y,CD47bd!3,c~i).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i).vegfr2(l1!2,Y1175~Y,CD47bd!4,c~i).CD47SIRPa(VEGFR2bd!4,c~i) -> Trash()

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,Y1175~pY,CD47bd!3,c~i2).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd,c~i2) -> Trash()

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,Y1175~Y,CD47bd!3,c~i2).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i2).vegfr2(l1!2,Y1175~Y,CD47bd,c~i2) -> Trash()

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,Y1175~pY,CD47bd!3,c~i2).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd!4,c~i2).CD47SIRPa(VEGFR2bd!4,c~i2) -> Trash()

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,Y1175~Y,CD47bd!3,c~i2).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i2).vegfr2(l1!2,Y1175~Y,CD47bd!4,c~i2).CD47SIRPa(VEGFR2bd!4,c~i2) -> Trash()

Single receptor

vegfr2(l1,CD47bd!1,c~i).CD47SIRPa(TSP1bd,VEGFR2bd!1,c~i) -> Trash()

vegfr2(l1,CD47bd,c~i) -> Trash()

vegfr2(l1,CD47bd!1,c~i).CD47SIRPa(TSP1bd!+,VEGFR2bd!1,c~i) -> Trash()

R2 receptor synthesis

I() -> I() + vegfr2(l1,Y1175~Y,CD47bd,dimer,c~s)

I() -> I() + CD47SIRPa(VEGFR2bd,TSP1bd,Y1~Y,c~s) ksingleR2syn*CD47free_0

vegfr2(l1,CD47bd,dimer,c~s) <-> vegfr2(l1,CD47bd,dimer,c~i)

vegfr2(l1,CD47bd!1,dimer,c~s).CD47SIRPa(VEGFR2bd!1,c~s) <-> vegfr2(l1,CD47bd!1,dimer,c~i).CD47SIRPa(VEGFR2bd!1,c~i)

vegfr2(l1,CD47bd,dimer!3,c~s).vegfr2(l1,CD47bd,dimer!3,c~s) <-> vegfr2(l1,CD47bd,dimer!3,c~i).vegfr2(l1,CD47bd,dimer!3,c~i)

vegfr2(l1,CD47bd!1,dimer!3,c~s).CD47SIRPa(VEGFR2bd!1,c~s).vegfr2(l1,CD47bd,dimer!3,c~s) <-> vegfr2(l1,CD47bd!1,dimer!3,c~i).CD47SIRPa(VEGFR2bd!1,c~i).vegfr2(l1,CD47bd,dimer!3,c~i)

vegfr2(l1,CD47bd!1,dimer!3,c~s).CD47SIRPa(VEGFR2bd!1,c~s).vegfr2(l1,CD47bd!2,dimer!3,c~s).CD47SIRPa(VEGFR2bd!2,c~s) <-> vegfr2(l1,CD47bd!1,dimer!3,c~i).CD47SIRPa(VEGFR2bd!1,c~i).vegfr2(l1,CD47bd!2,dimer!3,c~i).CD47SIRPa(VEGFR2bd!2,c~i)

Activating PLCgamma

PLCgamma(Yplc~Y) + vegfr2(Y1175~pY,c~s) -> PLCgamma(Yplc~pY) + vegfr2(Y1175~pY,c~s)

PLCgamma(Yplc~Y) + vegfr2(Y1175~pY,c~i) -> PLCgamma(Yplc~pY) + vegfr2(Y1175~pY,c~i)

PLCgamma(Yplc~Y) + vegfr2(Y1175~pY,c~i2) -> PLCgamma(Yplc~pY) + vegfr2(Y1175~pY,c~i2)

PLCgamma(Yplc~pY) -> PLCgamma(Yplc~Y)

IP3 and DAG generation

PLCgamma(Yplc~pY) + PI(PIsite~3P) -> IP3_cyto(ip3rbd) + PLCgamma(Yplc~pY)

PLCgamma(Yplc~pY) + PI(PIsite~3P) -> DAG(pkcbd) + PLCgamma(Yplc~pY)

I() -> I() + PI(PIsite~3P)

IP3_cyto(ip3rbd) -> Trash()

DAG(pkcbd) -> Trash()

Calcium_cyto(bd) + CaF(cabd) <-> Calcium_cyto(bd!1).CaF(cabd!1)

I() -> I() + Istim()

I() -> I() + Calcium_cyto(bd)

I() -> I() + CaER(bd)

I() -> I() + Calcium_cyto(bd)

I() -> I() + Calcium_cyto(bd)

I() -> I() + CaER(bd)

I() -> I() + CaER(bd)

Calcium binding to CaM

CaM(NCaM) + Calcium_cyto(bd) -> CaM(NCaM!1).Calcium_cyto(bd!1) + Calcium_cyto(bd)

CaM(NCaM!1).Calcium_cyto(bd!1) -> CaM(NCaM)

CaM(CCaM) + Calcium_cyto(bd) -> CaM(CCaM!1).Calcium_cyto(bd!1) + Calcium_cyto(bd)

CaM(CCaM!1).Calcium_cyto(bd!1) -> CaM(CCaM)

PI3K/AKT pathway
binding of TSAd (Tcell specific adaptor molecule)

TSADSrc(Y1~Y) + vegfr2(Y1175~pY!?,c~s) -> TSADSrc(Y1~pY) + vegfr2(Y1175~pY!?,c~s)

TSADSrc(Y1~Y) + vegfr2(Y1175~pY!?,c~i) -> TSADSrc(Y1~pY) + vegfr2(Y1175~pY!?,c~i)

TSADSrc(Y1~Y) + vegfr2(Y1175~pY!?,c~i2) -> TSADSrc(Y1~pY) + vegfr2(Y1175~pY!?,c~i2)

TSADSrc(Y1~pY) -> TSADSrc(Y1~Y)

Activation of Axl by Src

TSADSrc(Y1~pY) + Axl(Ysrc~Y) -> TSADSrc(Y1~pY) + Axl(Ysrc~pY)

Axl(Ysrc~pY,Yaxl~Y) -> Axl(Ysrc~pY,Yaxl~pY)

Axl(Yaxl~pY) -> Axl(Yaxl~Y)

Axl(Ysrc~pY) -> Axl(Ysrc~Y)

Binding of PI3K to activated Axl

PI3K(state~inactive) + Axl(Yaxl~pY) -> PI3K(state~active) + Axl(Yaxl~pY)

PI3K(state~active) -> PI3K(state~inactive)

PI3K(state~active) + PI(PIsite~3P) -> PI3K(state~active) + PI(PIsite~4P)

PTEN(PIP3docking) + PI(PIsite~4P) -> PTEN(PIP3docking) + PI(PIsite~3P)

PDK1(PHpdk1) + PI(PIsite~4P) <-> PDK1(PHpdk1!1).PI(PIsite~4P!1)

AKT(PHakt) + PI(PIsite~4P) <-> AKT(PHakt!1).PI(PIsite~4P!1)

AKT(PHakt!+,S473~S) -> AKT(PHakt!+,S473~pS)

⚠️ Molecule order mismatch - skipping reaction: reactants: AKT, PDK1 products: PDK1, AKT

AKT(S473~pS) -> AKT(S473~S)

AKT(T308~pS) -> AKT(T308~S)

eNOS activation by Ca/CaM and pAKT

CaM(NCaM!+,NCaM!+,CCaM!+,CCaM!+,CaMtargetbd) + eNOS(CaMBD) <-> CaM(NCaM!+,NCaM!+,CCaM!+,CCaM!+,CaMtargetbd!1).eNOS(CaMBD!1)

eNOS(CaMBD!+,cav1BD!1).caveolin1(eNOSbd!1) -> eNOS(CaMBD!+,cav1BD) + caveolin1(eNOSbd)

eNOS(cav1BD!1,S1177~pS).caveolin1(eNOSbd!1) -> eNOS(cav1BD,S1177~pS) + caveolin1(eNOSbd)

eNOS(CaMBD,cav1BD,S1177~S) + caveolin1(eNOSbd) -> eNOS(CaMBD,cav1BD!1,S1177~S).caveolin1(eNOSbd!1)

eNOS(CaMBD!+,S1177~S) + AKT(T308~pS,S473~pS) -> eNOS(CaMBD!+,S1177~pS) + AKT(T308~pS,S473~pS)

eNOS(S1177~pS) -> eNOS(S1177~S)

TSP1 binding to CD47SIRPa

I() -> I() + TSP1(CD47bd)

TSP1(CD47bd) + CD47SIRPa(TSP1bd,c~s) -> TSP1(CD47bd) + TSP1(CD47bd!1).CD47SIRPa(TSP1bd!1,c~s)

TSP1(CD47bd!1).CD47SIRPa(TSP1bd!1,c~s) -> CD47SIRPa(TSP1bd,c~s)

vegfr2(CD47bd,c~s) + CD47SIRPa(VEGFR2bd,c~s) -> vegfr2(CD47bd!1,c~s).CD47SIRPa(VEGFR2bd!1,c~s)

PKC(CalciumBD) + Calcium_cyto(bd) <-> PKC(CalciumBD!1).Calcium_cyto(bd!1)

PKC(DAGBD) + DAG(pkcbd) <-> PKC(DAGBD!1).DAG(pkcbd!1)

CIB1(EF1) + Calcium_cyto(bd) <-> CIB1(EF1!1).Calcium_cyto(bd!1)

CIB1(EF2) + Calcium_cyto(bd) <-> CIB1(EF2!1).Calcium_cyto(bd!1)

CIB1(EF1!+,EF2!+,sk1bd,location~cytosol) + SphK(CIB1bd,Serk~pS) <-> CIB1(EF1!+,EF2!+,sk1bd!1,location~cytosol).SphK(CIB1bd!1,Serk~pS)

ERK2(S2~pS) + SphK(Serk~S) -> ERK2(S2~pS) + SphK(Serk~pS)

CIB1(EF1!+,EF2!+,sk1bd!+,location~cytosol) <-> CIB1(EF1!+,EF2!+,sk1bd!+,location~membrane)

CIB1(EF1,EF2,location~membrane) -> CIB1(EF1,EF2,location~cytosol)

PKC(CalciumBD!+,DAGBD!1).DAG(pkcbd!1) + Raf(Spkc~S) -> PKC(CalciumBD!+,DAGBD!1).DAG(pkcbd!1) + Raf(Spkc~pS)

SphK(Serk~pS) -> SphK(Serk~S)

Raf(Spkc~pS) -> Raf(Spkc~S)

I() -> I() + Sph(skbd)

CIB1(sk1bd!1,location~membrane).SphK(CIB1bd!1,Serk~pS) + Sph(skbd) -> S1P(bd) + CIB1(sk1bd!1,location~membrane).SphK(CIB1bd!1,Serk~pS)

S1P(bd) -> Sph(skbd)

I() -> I() + RasGTP(rafbd)

Raf(rasbd) + RasGTP(rafbd) <-> Raf(rasbd!1).RasGTP(rafbd!1)

Raf(rasbd!1,Y1Y2~Y).RasGTP(rafbd!1) -> Raf(rasbd!1,Y1Y2~pY).RasGTP(rafbd!1)

Raf(Y1Y2~pY) -> Raf(Y1Y2~Y)

⚠️ Molecule order mismatch - skipping reaction: reactants: MEK12, Raf products: Raf, MEK12
⚠️ Molecule order mismatch - skipping reaction: reactants: MEK12, Raf products: Raf, MEK12
⚠️ Molecule order mismatch - skipping reaction: reactants: MEK12, Raf products: Raf, MEK12
⚠️ Molecule order mismatch - skipping reaction: reactants: MEK12, Raf products: Raf, MEK12
⚠️ Molecule order mismatch - skipping reaction: reactants: MEK12, Raf products: Raf, MEK12
⚠️ Molecule order mismatch - skipping reaction: reactants: MEK12, Raf products: Raf, MEK12

MEK12(S1~pS) -> MEK12(S1~S)

MEK12(S2~pS) -> MEK12(S2~S)

MEK12(S1~pS,S2~pS) + ERK1(S1~S) -> MEK12(S1~pS,S2~pS) + ERK1(S1~pS)

MEK12(S1~pS,S2~pS) + ERK2(S2~S) -> MEK12(S1~pS,S2~pS) + ERK2(S2~pS)

ERK1(S1~pS) -> ERK1(S1~S)

ERK2(S2~pS) -> ERK2(S2~S)