Molecules

vegf(r,r,nrp1bd,c~s~i~i2~r)

vegf r r nrp1bd c s i i2 r

vegfr2(l1,Y1175~Y~pY,CD47bd,dimer,c~s~i~i2~r)

vegfr2 l1 Y1175 Y pY CD47bd dimer c s i i2 r

vegfr1(l2,dimer,nrp1bd,c~s)

vegfr1 l2 dimer nrp1bd c s

NRP1(vegfabd,c~s~i~i2~r)

NRP1 vegfabd c s i i2 r

PI(PIsite~3P~4P)

PI PIsite 3P 4P

PLCgamma(Yplc~Y~pY)

PLCgamma Yplc Y pY

DAG(pkcbd)

DAG pkcbd

IP3_cyto(ip3rbd)

IP3_cyto ip3rbd

Calcium_cyto(bd)

Calcium_cyto bd

Trash()

Trash

CaER(bd)

CaER bd

CaF(cabd)

CaF cabd

CSQNF(cabd)

CSQNF cabd

CaM(NCaM,NCaM,CCaM,CCaM,CaMtargetbd)

CaM NCaM NCaM CCaM CCaM CaMtargetbd

I()

I

Istim()

Istim

PTEN(PIP3docking)

PTEN PIP3docking

TSADSrc(Y1~Y~pY)

TSADSrc Y1 Y pY

Axl(Ysrc~Y~pY,Yaxl~Y~pY)

Axl Ysrc Y pY Yaxl Y pY

PI3K(state~active~inactive)

PI3K state active inactive

AKT(PHakt,T308~S~pS,S473~S~pS)

AKT PHakt T308 S pS S473 S pS

PDK1(PHpdk1,aktbd)

PDK1 PHpdk1 aktbd

mTOR(aktbd)

mTOR aktbd

CD47SIRPa(VEGFR2bd,TSP1bd,Y1~Y~pY,c~s~i~i2~r)

CD47SIRPa VEGFR2bd TSP1bd Y1 Y pY c s i i2 r

TSP1(CD47bd)

TSP1 CD47bd

eNOS(CaMBD,S1177~S~pS,cav1BD)

eNOS CaMBD S1177 S pS cav1BD

caveolin1(eNOSbd)

caveolin1 eNOSbd

PKC(CalciumBD,DAGBD)

PKC CalciumBD DAGBD

CIB1(EF1,EF2,sk1bd,location~cytosol~membrane)

CIB1 EF1 EF2 sk1bd location cytosol membrane

SphK(CIB1bd,Serk~S~pS)

SphK CIB1bd Serk S pS

Sph(skbd)

Sph skbd

S1P(bd)

S1P bd

RasGDP(rafbd)

RasGDP rafbd

RasGTP(rafbd)

RasGTP rafbd

Raf(mekbd,rasbd,Y1Y2~Y~pY,Spkc~S~pS)

Raf mekbd rasbd Y1Y2 Y pY Spkc S pS

MEK12(bd,S1~S~pS,S2~S~pS)

MEK12 bd S1 S pS S2 S pS

ERK1(MEK12bd,S1~S~pS)

ERK1 MEK12bd S1 S pS

ERK2(MEK12bd,S2~S~pS)

ERK2 MEK12bd S2 S pS

Species

vegf(r,r,nrp1bd,c~s)

vegf r r nrp1bd c s

vegfr1(l2,dimer,nrp1bd,c~s)

vegfr1 l2 dimer nrp1bd c s

vegfr2(l1,Y1175~Y,CD47bd,dimer,c~s)

vegfr2 l1 Y1175 Y CD47bd dimer c s

NRP1(vegfabd,c~s)

NRP1 vegfabd c s

PI(PIsite~3P)

PI PIsite 3P

PLCgamma(Yplc~Y)

PLCgamma Yplc Y

CaER(bd)

CaER bd

Calcium_cyto(bd)

Calcium_cyto bd

CaF(cabd)

CaF cabd

Calcium_cyto(bd!1).CaF(cabd!1)

Calcium_cyto 1bd CaF 1cabd

CaM(NCaM,NCaM,CCaM,CCaM,CaMtargetbd)

CaM NCaM NCaM CCaM CCaM CaMtargetbd

I()

I

Istim()

Istim

PTEN(PIP3docking)

PTEN PIP3docking

TSADSrc(Y1~Y)

TSADSrc Y1 Y

Axl(Ysrc~Y,Yaxl~Y)

Axl Ysrc Y Yaxl Y

PI3K(state~inactive)

PI3K state inactive

AKT(PHakt,T308~S,S473~S)

AKT PHakt T308 S S473 S

PDK1(PHpdk1,aktbd)

PDK1 PHpdk1 aktbd

mTOR(aktbd)

mTOR aktbd

TSP1(CD47bd)

TSP1 CD47bd

CD47SIRPa(VEGFR2bd,TSP1bd,Y1~Y,c~s)

CD47SIRPa VEGFR2bd TSP1bd Y1 Y c s

eNOS(CaMBD,S1177~S,cav1BD!1).caveolin1(eNOSbd!1)

eNOS CaMBD S1177 S 1cav1BD caveolin1 1eNOSbd

PKC(CalciumBD,DAGBD)

PKC CalciumBD DAGBD

CIB1(EF1,EF2,sk1bd,location~cytosol)

CIB1 EF1 EF2 sk1bd location cytosol

SphK(CIB1bd,Serk~S)

SphK CIB1bd Serk S

Sph(skbd)

Sph skbd

S1P(bd)

S1P bd

RasGDP(rafbd)

RasGDP rafbd

RasGTP(rafbd)

RasGTP rafbd

Raf(mekbd,rasbd,Y1Y2~Y,Spkc~S)

Raf mekbd rasbd Y1Y2 Y Spkc S

MEK12(bd,S1~S,S2~S)

MEK12 bd S1 S S2 S

ERK1(MEK12bd,S1~S)

ERK1 MEK12bd S1 S

ERK2(MEK12bd,S2~S)

ERK2 MEK12bd S2 S

Observables

vegf(r,r,nrp1bd,c~s)

vegf r r nrp1bd c s

vegfr2()

vegfr2 l1 Y1175 Y pY CD47bd dimer c s i i2 r

TSP1(CD47bd)

TSP1 CD47bd

TSP1(CD47bd!1).CD47SIRPa(TSP1bd!1,Y1~Y,c~s)

TSP1 1CD47bd CD47SIRPa VEGFR2bd 1TSP1bd Y1 Y c s

CD47SIRPa(TSP1bd,Y1~Y,c~s)

CD47SIRPa VEGFR2bd TSP1bd Y1 Y c s

vegfr2(c~s)

vegfr2 l1 Y1175 Y pY CD47bd dimer c s

vegfr2(c~i)

vegfr2 l1 Y1175 Y pY CD47bd dimer c i

vegfr2(l1,c~s)

vegfr2 l1 Y1175 Y pY CD47bd dimer c s

vegfr2(l1,c~i)

vegfr2 l1 Y1175 Y pY CD47bd dimer c i

vegfr1(l2,nrp1bd,c~s)

vegfr1 l2 dimer nrp1bd c s

vegfr2(Y1175~pY!?,c~s)

vegfr2 l1 Y1175 pY CD47bd dimer c s

vegfr2(Y1175~pY!?,c~i)

vegfr2 l1 Y1175 pY CD47bd dimer c i

vegfr2(Y1175~pY!?)

vegfr2 l1 Y1175 pY CD47bd dimer c s i i2 r

vegfr1(c~s)

vegfr1 l2 dimer nrp1bd c s

vegf(r!1,r!2,nrp1bd!+,c~s).vegfr2(l1!1,c~s).vegfr2(l1!2,c~s)

vegf 1r 2r nrp1bd c s vegfr2 1l1 Y1175 Y pY CD47bd dimer c s vegfr2 2l1 Y1175 Y pY CD47bd dimer c s

vegf(r!1,r!2,nrp1bd!+,c~i).vegfr2(l1!1,c~i).vegfr2(l1!2,c~i)

vegf 1r 2r nrp1bd c i vegfr2 1l1 Y1175 Y pY CD47bd dimer c i vegfr2 2l1 Y1175 Y pY CD47bd dimer c i

DAG(pkcbd!?)

DAG pkcbd

PLCgamma(Yplc~pY!?)

PLCgamma Yplc pY

PI(PIsite~3P)

PI PIsite 3P

PI(PIsite~4P)

PI PIsite 4P

IP3_cyto(ip3rbd)

IP3_cyto ip3rbd

Calcium_cyto(bd)

Calcium_cyto bd

CaER(bd)

CaER bd

CaF(cabd!+)

CaF cabd

PKC(CalciumBD!+,DAGBD!1).DAG(pkcbd!1)

PKC CalciumBD 1DAGBD DAG 1pkcbd

PKC(CalciumBD!+,DAGBD!+)

PKC CalciumBD DAGBD

SphK(Serk~pS!?)

SphK CIB1bd Serk pS

S1P(bd)

S1P bd

NRP1(vegfabd,c~s)

NRP1 vegfabd c s

NRP1(vegfabd,c~i)

NRP1 vegfabd c i

NRP1(vegfabd!+,c~s)

NRP1 vegfabd c s

NRP1(vegfabd!+,c~i)

NRP1 vegfabd c i

vegfr2(l1,dimer!1,c~s).vegfr2(l1,dimer!1,c~s)

vegfr2 l1 Y1175 Y pY CD47bd 1dimer c s vegfr2 l1 Y1175 Y pY CD47bd 1dimer c s

vegfr2(l1,dimer!1,c~i).vegfr2(l1,dimer!1,c~i)

vegfr2 l1 Y1175 Y pY CD47bd 1dimer c i vegfr2 l1 Y1175 Y pY CD47bd 1dimer c i

NRP1(c~s)

NRP1 vegfabd c s

NRP1(c~i)

NRP1 vegfabd c i

NRP1(vegfabd,c~s)

NRP1 vegfabd c s

NRP1(vegfabd,c~i)

NRP1 vegfabd c i

vegf(r!1).vegfr2(l1!1)

vegf 1r r nrp1bd c s i i2 r vegfr2 1l1 Y1175 Y pY CD47bd dimer c s i i2 r

vegfr2(Y1175~pY,c~s)

vegfr2 l1 Y1175 pY CD47bd dimer c s

vegfr2(Y1175~pY,c~i)

vegfr2 l1 Y1175 pY CD47bd dimer c i

PLCgamma(Yplc~Y)

PLCgamma Yplc Y

RasGDP(rafbd!?)

RasGDP rafbd

RasGTP(rafbd!?)

RasGTP rafbd

Raf(Y1Y2~pY!?)

Raf mekbd rasbd Y1Y2 pY Spkc S pS

MEK12(S1~pS!?,S2~pS!?)

MEK12 bd S1 pS S2 pS

ERK1(S1~pS!?)

ERK1 MEK12bd S1 pS

ERK2(S2~pS!?)

ERK2 MEK12bd S2 pS

SphK(CIB1bd!+,Serk~S).CIB1(sk1bd!1,location~membrane)

SphK CIB1bd Serk S CIB1 EF1 EF2 1sk1bd location membrane

SphK(CIB1bd!+,Serk~pS).CIB1(sk1bd!1,location~membrane)

SphK CIB1bd Serk pS CIB1 EF1 EF2 1sk1bd location membrane

SphK(CIB1bd!+,Serk~S).CIB1(sk1bd!1,location~cytosol)

SphK CIB1bd Serk S CIB1 EF1 EF2 1sk1bd location cytosol

SphK(Serk~pS!?)

SphK CIB1bd Serk pS

SphK(CIB1bd,Serk~S)

SphK CIB1bd Serk S

SphK(CIB1bd!1,Serk~S).CIB1(sk1bd!1,location~membrane)

SphK 1CIB1bd Serk S CIB1 EF1 EF2 1sk1bd location membrane

CIB1(EF1,EF2,sk1bd)

CIB1 EF1 EF2 sk1bd location cytosol membrane

CIB1(EF1!+,EF2!+,sk1bd)

CIB1 EF1 EF2 sk1bd location cytosol membrane

CIB1(EF1!+,EF2!+,sk1bd!+)

CIB1 EF1 EF2 sk1bd location cytosol membrane

NRP1(vegfabd,c~s)

NRP1 vegfabd c s

vegf(r,r,nrp1bd!1,c~s).NRP1(vegfabd!1,c~s)

vegf r r 1nrp1bd c s NRP1 1vegfabd c s

vegf(r!1,r,nrp1bd,c~s).vegfr1(l2!1,c~s)

vegf 1r r nrp1bd c s vegfr1 1l2 dimer nrp1bd c s

vegf(r!1,r,nrp1bd,c~s).vegfr2(l1!1,dimer,c~s)

vegf 1r r nrp1bd c s vegfr2 1l1 Y1175 Y pY CD47bd dimer c s

PI(PIsite~3P)

PI PIsite 3P

Sph(skbd)

Sph skbd

Raf(Spkc~S)

Raf mekbd rasbd Y1Y2 Y pY Spkc S

Raf(Spkc~pS!?)

Raf mekbd rasbd Y1Y2 Y pY Spkc pS

Raf(Spkc~pS!?,Y1Y2~pY!?)

Raf mekbd rasbd Y1Y2 pY Spkc pS

Raf(Spkc~pS!?,Y1Y2~Y!?)

Raf mekbd rasbd Y1Y2 Y Spkc pS

Raf(Spkc~S!?,Y1Y2~pY!?)

Raf mekbd rasbd Y1Y2 pY Spkc S

Raf(Y1Y2~pY,Spkc~S)

Raf mekbd rasbd Y1Y2 pY Spkc S

Raf(Y1Y2~pY,Spkc~pS)

Raf mekbd rasbd Y1Y2 pY Spkc pS

Raf(Y1Y2~Y,Spkc~pS)

Raf mekbd rasbd Y1Y2 Y Spkc pS

ERK1(S1~S)

ERK1 MEK12bd S1 S

MEK12(S1~S,S2~S)

MEK12 bd S1 S S2 S

vegfr2(l1,Y1175~Y,dimer,c~i)

vegfr2 l1 Y1175 Y CD47bd dimer c i

ERK1(S1~pS)

ERK1 MEK12bd S1 pS

MEK12(S1~pS,S2~S)

MEK12 bd S1 pS S2 S

ERK2(S2~pS)

ERK2 MEK12bd S2 pS

MEK12(S1~pS)

MEK12 bd S1 pS S2 S pS

MEK12(S2~pS)

MEK12 bd S1 S pS S2 pS

ERK1(S1~pS)

ERK1 MEK12bd S1 pS

ERK2(S2~pS)

ERK2 MEK12bd S2 pS

vegfr2(Y1175~pY,c~s)

vegfr2 l1 Y1175 pY CD47bd dimer c s

vegfr2(Y1175~pY,c~i)

vegfr2 l1 Y1175 pY CD47bd dimer c i

vegf(r!1,r,c~s).vegfr2(l1!1,Y1175~pY,c~s)

vegf 1r r nrp1bd c s vegfr2 1l1 Y1175 pY CD47bd dimer c s

vegf(r!1,r,c~i).vegfr2(l1!1,Y1175~pY,c~i)

vegf 1r r nrp1bd c i vegfr2 1l1 Y1175 pY CD47bd dimer c i

vegfr2(l1,Y1175~pY,c~s)

vegfr2 l1 Y1175 pY CD47bd dimer c s

vegfr2(l1,Y1175~pY,c~i)

vegfr2 l1 Y1175 pY CD47bd dimer c i

vegf(r!1,r!2,c~s).vegfr1(l2!1,c~s).vegfr2(l1!2,Y1175~pY,c~s)

vegf 1r 2r nrp1bd c s vegfr1 1l2 dimer nrp1bd c s vegfr2 2l1 Y1175 pY CD47bd dimer c s

SphK(Serk~pS)

SphK CIB1bd Serk pS

S1P(bd)

S1P bd

Raf(Y1Y2~pY)

Raf mekbd rasbd Y1Y2 pY Spkc S pS

vegf(r,r,nrp1bd!1,c~i).NRP1(vegfabd!1,c~i)

vegf r r 1nrp1bd c i NRP1 1vegfabd c i

vegf(r!1,r,nrp1bd,c~i).vegfr2(l1!1,c~i)

vegf 1r r nrp1bd c i vegfr2 1l1 Y1175 Y pY CD47bd dimer c i

NRP1(vegfabd)

NRP1 vegfabd c s i i2 r

PLCgamma(Yplc~pY)

PLCgamma Yplc pY

ERK1(S1~pS!?)

ERK1 MEK12bd S1 pS

ERK2(S2~pS!?)

ERK2 MEK12bd S2 pS

MEK12(S1~pS!?,S2~S)

MEK12 bd S1 pS S2 S

MEK12(S1~S,S2~pS!?)

MEK12 bd S1 S S2 pS

SphK(CIB1bd,Serk~S)

SphK CIB1bd Serk S

Raf(Spkc~pS)

Raf mekbd rasbd Y1Y2 Y pY Spkc pS

MEK12(S1~S)

MEK12 bd S1 S S2 S pS

MEK12(S2~S)

MEK12 bd S1 S pS S2 S

ERK1(S1~S)

ERK1 MEK12bd S1 S

ERK2(S2~S)

ERK2 MEK12bd S2 S

PLCgamma(Yplc~Y)

PLCgamma Yplc Y

RasGTP(rafbd)

RasGTP rafbd

vegf(r!1,nrp1bd,c~s).vegfr2(l1!1,c~s)

vegf 1r r nrp1bd c s vegfr2 1l1 Y1175 Y pY CD47bd dimer c s

vegf(nrp1bd!1,c~s).NRP1(vegfabd!1,c~s)

vegf r r 1nrp1bd c s NRP1 1vegfabd c s

vegf(r!1,nrp1bd,c~s).vegfr1(l2!1,c~s)

vegf 1r r nrp1bd c s vegfr1 1l2 dimer nrp1bd c s

vegf(r!1,r!2,c~s).vegfr1(l2!1,c~s).vegfr1(l2!2,c~s)

vegf 1r 2r nrp1bd c s vegfr1 1l2 dimer nrp1bd c s vegfr1 2l2 dimer nrp1bd c s

vegf(r!1,c~s).vegfr2(l1!1,c~s)

vegf 1r r nrp1bd c s vegfr2 1l1 Y1175 Y pY CD47bd dimer c s

vegf(r!1,c~s).vegfr1(l2!1,c~s)

vegf 1r r nrp1bd c s vegfr1 1l2 dimer nrp1bd c s

vegf(r!+,nrp1bd,c~s)

vegf r r nrp1bd c s

vegf(r,nrp1bd!+,c~s)

vegf r r nrp1bd c s

vegf(r!+,c~s)

vegf r r nrp1bd c s

vegf(r,r,nrp1bd!1,c~s).NRP1(vegfabd!1,c~s)

vegf r r 1nrp1bd c s NRP1 1vegfabd c s

Istim()

Istim

NRP1(vegfabd!1,c~s).vegfr1(nrp1bd!1,c~s)

NRP1 1vegfabd c s vegfr1 l2 dimer 1nrp1bd c s

CIB1(location~membrane)

CIB1 EF1 EF2 sk1bd location membrane

PI(PIsite~4P)

PI PIsite 4P

AKT(S473~pS)

AKT PHakt T308 S pS S473 pS

AKT(T308~pS)

AKT PHakt T308 pS S473 S pS

Axl(Ysrc~pY!?,Yaxl~pY!?)

Axl Ysrc pY Yaxl pY

Axl(Ysrc~pY!?)

Axl Ysrc pY Yaxl Y pY

Axl(Yaxl~pY!?)

Axl Ysrc Y pY Yaxl pY

TSADSrc(Y1~pY!?)

TSADSrc Y1 pY

eNOS(S1177~pS)

eNOS CaMBD S1177 pS cav1BD

AKT(S473~pS,T308~pS)

AKT PHakt T308 pS S473 pS

Reaction Rules

Ligand-independent coupling of the receptors

vegfr2(l1,dimer,c~s) + vegfr2(l1,dimer,c~s) <-> vegfr2(l1,dimer!1,c~s).vegfr2(l1,dimer!1,c~s)

vegfr2 l1 Y1175 Y pY CD47bd 1 ⬆⬇dimer c s vegfr2 l1 Y1175 Y pY CD47bd 1 ⬆⬇dimer c s

vegfr2(l1,dimer,c~s) + vegfr1(l2,dimer,c~s) <-> vegfr2(l1,dimer!1,c~s).vegfr1(l2,dimer!1,c~s)

vegfr2 l1 Y1175 Y pY CD47bd 1 ⬆⬇dimer c s vegfr1 l2 1 ⬆⬇dimer nrp1bd c s

vegfr1(l2,dimer,c~s) + vegfr1(l2,dimer,c~s) <-> vegfr1(l2,dimer!1,c~s).vegfr1(l2,dimer!1,c~s)

vegfr1 l2 1 ⬆⬇dimer nrp1bd c s vegfr1 l2 1 ⬆⬇dimer nrp1bd c s

vegf(r!1,r!2,c~s).vegfr2(l1!1,dimer,c~s).vegfr2(l1!2,dimer,c~s) <-> vegf(r!1,r!2,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr2(l1!2,dimer!3,c~s)

vegf 1r 2r nrp1bd c s vegfr2 1l1 Y1175 Y pY CD47bd 3 ⬆⬇dimer c s vegfr2 2l1 Y1175 Y pY CD47bd 3 ⬆⬇dimer c s

vegf(r!1,r!2,c~s).vegfr2(l1!1,dimer,c~s).vegfr1(l2!2,dimer,c~s) <-> vegf(r!1,r!2,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s)

vegf 1r 2r nrp1bd c s vegfr2 1l1 Y1175 Y pY CD47bd 3 ⬆⬇dimer c s vegfr1 2l2 3 ⬆⬇dimer nrp1bd c s

vegf(r!1,r!2,c~s).vegfr1(l2!1,dimer,c~s).vegfr1(l2!2,dimer,c~s) <-> vegf(r!1,r!2,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s)

vegf 1r 2r nrp1bd c s vegfr1 1l2 3 ⬆⬇dimer nrp1bd c s vegfr1 2l2 3 ⬆⬇dimer nrp1bd c s
VEGFR1 binding to NRP1

vegfr1(nrp1bd,c~s) + NRP1(vegfabd,c~s) <-> vegfr1(nrp1bd!1,c~s).NRP1(vegfabd!1,c~s)

vegfr1 l2 dimer 1 ⬆⬇nrp1bd c s NRP1 1 ⬆⬇vegfabd c s
Binding of VEGF165a to NRP1

vegf(r,r,nrp1bd!+,c~s) + vegfr2(l1,dimer,c~s) <-> vegf(r!2,r,nrp1bd!+,c~s).vegfr2(l1!2,dimer,c~s)

vegf 2 ⬆⬇r r nrp1bd c s vegfr2 2 ⬆⬇l1 Y1175 Y pY CD47bd dimer c s

vegf(r,r,nrp1bd!+,c~s) + vegfr2(l1,dimer!3,c~s).vegfr2(l1,dimer!3,c~s) <-> vegf(r!2,r,nrp1bd!+,c~s).vegfr2(l1!2,dimer!3,c~s).vegfr2(l1,dimer!3,c~s)

vegf 2 ⬆⬇r r nrp1bd c s vegfr2 2 ⬆⬇l1 Y1175 Y pY CD47bd 3dimer c s vegfr2 l1 Y1175 Y pY CD47bd 3dimer c s

vegf(r,r,nrp1bd!+,c~s) + vegfr2(l1,dimer!3,c~s).vegfr1(l2,dimer!3,c~s) <-> vegf(r!2,r,nrp1bd!+,c~s).vegfr2(l1!2,dimer!3,c~s).vegfr1(l2,dimer!3,c~s)

vegf 2 ⬆⬇r r nrp1bd c s vegfr2 2 ⬆⬇l1 Y1175 Y pY CD47bd 3dimer c s vegfr1 l2 3dimer nrp1bd c s

vegf(r,r,nrp1bd!+,c~s) + vegfr1(l2,dimer,c~s) <-> vegf(r!2,r,nrp1bd!+,c~s).vegfr1(l2!2,dimer,c~s)

vegf 2 ⬆⬇r r nrp1bd c s vegfr1 2 ⬆⬇l2 dimer nrp1bd c s

vegf(r,r,nrp1bd!+,c~s) + vegfr1(l2,dimer!3,c~s).vegfr1(l2,dimer!3,c~s) <-> vegf(r!2,r,nrp1bd!+,c~s).vegfr1(l2!2,dimer!3,c~s).vegfr1(l2,dimer!3,c~s)

vegf 2 ⬆⬇r r nrp1bd c s vegfr1 2 ⬆⬇l2 3dimer nrp1bd c s vegfr1 l2 3dimer nrp1bd c s

vegf(r,r,nrp1bd!+,c~s) + vegfr1(l2,dimer!3,c~s).vegfr2(l1,dimer!3,c~s) <-> vegf(r!2,r,nrp1bd!+,c~s).vegfr1(l2!2,dimer!3,c~s).vegfr2(l1,dimer!3,c~s)

vegf 2 ⬆⬇r r nrp1bd c s vegfr1 2 ⬆⬇l2 3dimer nrp1bd c s vegfr2 l1 Y1175 Y pY CD47bd 3dimer c s
Binding of VEGF165a to VEGFR2 receptors

vegf(r!1,r,nrp1bd,c~s).vegfr2(l1!1,dimer,c~s) + vegfr2(l1,dimer,c~s) <-> vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,dimer,c~s).vegfr2(l1!2,dimer,c~s)

vegf 1r 2 ⬆⬇r nrp1bd c s vegfr2 1l1 Y1175 Y pY CD47bd dimer c s vegfr2 2 ⬆⬇l1 Y1175 Y pY CD47bd dimer c s

vegf(r!1,r,nrp1bd,c~s).vegfr2(l1!1,dimer,c~s) + vegfr1(l2,dimer,c~s) <-> vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,dimer,c~s).vegfr1(l2!2,dimer,c~s)

vegf 1r 2 ⬆⬇r nrp1bd c s vegfr2 1l1 Y1175 Y pY CD47bd dimer c s vegfr1 2 ⬆⬇l2 dimer nrp1bd c s

vegf(r!1,r,nrp1bd,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr2(l1,dimer!3,c~s) <-> vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr2(l1!2,dimer!3,c~s)

vegf 1r 2 ⬆⬇r nrp1bd c s vegfr2 1l1 Y1175 Y pY CD47bd 3dimer c s vegfr2 2 ⬆⬇l1 Y1175 Y pY CD47bd 3dimer c s

vegf(r!1,r,nrp1bd,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr1(l2,dimer!3,c~s) <-> vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s)

vegf 1r 2 ⬆⬇r nrp1bd c s vegfr2 1l1 Y1175 Y pY CD47bd 3dimer c s vegfr1 2 ⬆⬇l2 3dimer nrp1bd c s

vegf(r!1,r,nrp1bd,c~s).vegfr1(l2!1,dimer,c~s) + vegfr1(l2,dimer,c~s) <-> vegf(r!1,r!2,nrp1bd,c~s).vegfr1(l2!1,dimer,c~s).vegfr1(l2!2,dimer,c~s)

vegf 1r 2 ⬆⬇r nrp1bd c s vegfr1 1l2 dimer nrp1bd c s vegfr1 2 ⬆⬇l2 dimer nrp1bd c s

vegf(r!1,r,nrp1bd,c~s).vegfr1(l2!1,dimer,c~s) + vegfr2(l1,dimer,c~s) <-> vegf(r!1,r!2,nrp1bd,c~s).vegfr1(l2!1,dimer,c~s).vegfr2(l1!2,dimer,c~s)

vegf 1r 2 ⬆⬇r nrp1bd c s vegfr1 1l2 dimer nrp1bd c s vegfr2 2 ⬆⬇l1 Y1175 Y pY CD47bd dimer c s

vegf(r!1,r,nrp1bd,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr1(l2,dimer!3,c~s) <-> vegf(r!1,r!2,nrp1bd,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s)

vegf 1r 2 ⬆⬇r nrp1bd c s vegfr1 1l2 3dimer nrp1bd c s vegfr1 2 ⬆⬇l2 3dimer nrp1bd c s

vegf(r!1,r,nrp1bd,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr2(l1,dimer!3,c~s) <-> vegf(r!1,r!2,nrp1bd,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr2(l1!2,dimer!3,c~s)

vegf 1r 2 ⬆⬇r nrp1bd c s vegfr1 1l2 3dimer nrp1bd c s vegfr2 2 ⬆⬇l1 Y1175 Y pY CD47bd 3dimer c s

vegf(r!1,r,nrp1bd!+,c~s).vegfr2(l1!1,dimer,c~s) + vegfr2(l1,dimer,c~s) <-> vegf(r!1,r!2,nrp1bd!+,c~s).vegfr2(l1!1,dimer,c~s).vegfr2(l1!2,dimer,c~s)

vegf 1r 2 ⬆⬇r nrp1bd c s vegfr2 1l1 Y1175 Y pY CD47bd dimer c s vegfr2 2 ⬆⬇l1 Y1175 Y pY CD47bd dimer c s

vegf(r!1,r,nrp1bd!+,c~s).vegfr2(l1!1,dimer,c~s) + vegfr1(l2,dimer,c~s) <-> vegf(r!1,r!2,nrp1bd!+,c~s).vegfr2(l1!1,dimer,c~s).vegfr1(l2!2,dimer,c~s)

vegf 1r 2 ⬆⬇r nrp1bd c s vegfr2 1l1 Y1175 Y pY CD47bd dimer c s vegfr1 2 ⬆⬇l2 dimer nrp1bd c s

vegf(r!1,r,nrp1bd!+,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr2(l1,dimer!3,c~s) <-> vegf(r!1,r!2,nrp1bd!+,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr2(l1!2,dimer!3,c~s)

vegf 1r 2 ⬆⬇r nrp1bd c s vegfr2 1l1 Y1175 Y pY CD47bd 3dimer c s vegfr2 2 ⬆⬇l1 Y1175 Y pY CD47bd 3dimer c s

vegf(r!1,r,nrp1bd!+,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr1(l2,dimer!3,c~s) <-> vegf(r!1,r!2,nrp1bd!+,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s)

vegf 1r 2 ⬆⬇r nrp1bd c s vegfr2 1l1 Y1175 Y pY CD47bd 3dimer c s vegfr1 2 ⬆⬇l2 3dimer nrp1bd c s

vegf(r!1,r,nrp1bd!+,c~s).vegfr1(l2!1,dimer,c~s) + vegfr1(l2,dimer,c~s) <-> vegf(r!1,r!2,nrp1bd!+,c~s).vegfr1(l2!1,dimer,c~s).vegfr1(l2!2,dimer,c~s)

vegf 1r 2 ⬆⬇r nrp1bd c s vegfr1 1l2 dimer nrp1bd c s vegfr1 2 ⬆⬇l2 dimer nrp1bd c s

vegf(r!1,r,nrp1bd!+,c~s).vegfr1(l2!1,dimer,c~s) + vegfr2(l1,dimer,c~s) <-> vegf(r!1,r!2,nrp1bd!+,c~s).vegfr1(l2!1,dimer,c~s).vegfr2(l1!2,dimer,c~s)

vegf 1r 2 ⬆⬇r nrp1bd c s vegfr1 1l2 dimer nrp1bd c s vegfr2 2 ⬆⬇l1 Y1175 Y pY CD47bd dimer c s

vegf(r!1,r,nrp1bd!+,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr1(l2,dimer!3,c~s) <-> vegf(r!1,r!2,nrp1bd!+,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s)

vegf 1r 2 ⬆⬇r nrp1bd c s vegfr1 1l2 3dimer nrp1bd c s vegfr1 2 ⬆⬇l2 3dimer nrp1bd c s

vegf(r!1,r,nrp1bd!+,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr2(l1,dimer!3,c~s) <-> vegf(r!1,r!2,nrp1bd!+,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr2(l1!2,dimer!3,c~s)

vegf 1r 2 ⬆⬇r nrp1bd c s vegfr1 1l2 3dimer nrp1bd c s vegfr2 2 ⬆⬇l1 Y1175 Y pY CD47bd 3dimer c s

vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr2(l1!2,dimer!3,c~s) + NRP1(vegfabd,c~s) <-> vegf(r!1,r!2,nrp1bd!4,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr2(l1!2,dimer!3,c~s).NRP1(vegfabd!4,c~s)

vegf 1r 2r 4 ⬆⬇nrp1bd c s vegfr2 1l1 Y1175 Y pY CD47bd 3dimer c s vegfr2 2l1 Y1175 Y pY CD47bd 3dimer c s NRP1 4 ⬆⬇vegfabd c s

vegf(r!1,r!2,nrp1bd,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s) + NRP1(vegfabd,c~s) <-> vegf(r!1,r!2,nrp1bd!4,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s).NRP1(vegfabd!4,c~s)

vegf 1r 2r 4 ⬆⬇nrp1bd c s vegfr1 1l2 3dimer nrp1bd c s vegfr1 2l2 3dimer nrp1bd c s NRP1 4 ⬆⬇vegfabd c s

vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s) + NRP1(vegfabd,c~s) <-> vegf(r!1,r!2,nrp1bd!4,c~s).vegfr2(l1!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s).NRP1(vegfabd!4,c~s)

vegf 1r 2r 4 ⬆⬇nrp1bd c s vegfr2 1l1 Y1175 Y pY CD47bd 3dimer c s vegfr1 2l2 3dimer nrp1bd c s NRP1 4 ⬆⬇vegfabd c s

vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,dimer,c~s).vegfr2(l1!2,dimer,c~s) + NRP1(vegfabd,c~s) <-> vegf(r!1,r!2,nrp1bd!4,c~s).vegfr2(l1!1,dimer,c~s).vegfr2(l1!2,dimer,c~s).NRP1(vegfabd!4,c~s)

vegf 1r 2r 4 ⬆⬇nrp1bd c s vegfr2 1l1 Y1175 Y pY CD47bd dimer c s vegfr2 2l1 Y1175 Y pY CD47bd dimer c s NRP1 4 ⬆⬇vegfabd c s

vegf(r!1,r,nrp1bd,c~s).vegfr2(l1!1,c~s) + NRP1(vegfabd,c~s) <-> vegf(r!1,r,nrp1bd!2,c~s).vegfr2(l1!1,c~s).NRP1(vegfabd!2,c~s)

vegf 1r r 2 ⬆⬇nrp1bd c s vegfr2 1l1 Y1175 Y pY CD47bd dimer c s NRP1 2 ⬆⬇vegfabd c s

vegf(r!1,r,nrp1bd,c~s).vegfr1(l2!1,c~s) + NRP1(vegfabd,c~s) <-> vegf(r!1,r,nrp1bd!2,c~s).vegfr1(l2!1,c~s).NRP1(vegfabd!2,c~s)

vegf 1r r 2 ⬆⬇nrp1bd c s vegfr1 1l2 dimer nrp1bd c s NRP1 2 ⬆⬇vegfabd c s
#######################vegf165a binding to vegfr1

vegf(r!1,r,c~s).vegfr1(l2!1,dimer,c~s) + vegfr1(l2,dimer,c~s) <-> vegf(r!1,r!2,c~s).vegfr1(l2!1,dimer,c~s).vegfr1(l2!2,dimer,c~s)

vegf 1r 2 ⬆⬇r nrp1bd c s vegfr1 1l2 dimer nrp1bd c s vegfr1 2 ⬆⬇l2 dimer nrp1bd c s

vegf(r!1,r,c~s).vegfr1(l2!1,dimer,c~s) + vegfr2(l1,dimer,c~s) <-> vegf(r!1,r!2,c~s).vegfr1(l2!1,dimer,c~s).vegfr2(l1!2,dimer,c~s)

vegf 1r 2 ⬆⬇r nrp1bd c s vegfr1 1l2 dimer nrp1bd c s vegfr2 2 ⬆⬇l1 Y1175 Y pY CD47bd dimer c s

vegf(r!1,r,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr1(l2,dimer!3,c~s) <-> vegf(r!1,r!2,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr1(l2!2,dimer!3,c~s)

vegf 1r 2 ⬆⬇r nrp1bd c s vegfr1 1l2 3dimer nrp1bd c s vegfr1 2 ⬆⬇l2 3dimer nrp1bd c s

vegf(r!1,r,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr2(l1,dimer!3,c~s) <-> vegf(r!1,r!2,c~s).vegfr1(l2!1,dimer!3,c~s).vegfr2(l1!2,dimer!3,c~s)

vegf 1r 2 ⬆⬇r nrp1bd c s vegfr1 1l2 3dimer nrp1bd c s vegfr2 2 ⬆⬇l1 Y1175 Y pY CD47bd 3dimer c s
################################Receptor phosphorylation

vegf(r!1,r!2,c~s).vegfr2(l1!1,c~s).vegfr2(l1!2,Y1175~Y,c~s) -> vegf(r!1,r!2,c~s).vegfr2(l1!1,c~s).vegfr2(l1!2,Y1175~pY,c~s)

vegf 1r 2r nrp1bd c s vegfr2 1l1 Y1175 Y pY CD47bd dimer c s vegfr2 2l1 Y1175 Y pY take all branches, once each, in any order⬇⬇ CD47bd dimer c s

vegf(r!1,r!2,c~i).vegfr2(l1!1,c~i).vegfr2(l1!2,Y1175~Y,c~i) -> vegf(r!1,r!2,c~i).vegfr2(l1!1,c~i).vegfr2(l1!2,Y1175~pY,c~i)

vegf 1r 2r nrp1bd c i vegfr2 1l1 Y1175 Y pY CD47bd dimer c i vegfr2 2l1 Y1175 Y pY take all branches, once each, in any order⬇⬇ CD47bd dimer c i

vegf(r!1,r!2,c~i2).vegfr2(l1!1,c~i2).vegfr2(l1!2,Y1175~Y,c~i2) -> vegf(r!1,r!2,c~i2).vegfr2(l1!1,c~i2).vegfr2(l1!2,Y1175~pY,c~i2)

vegf 1r 2r nrp1bd c i2 vegfr2 1l1 Y1175 Y pY CD47bd dimer c i2 vegfr2 2l1 Y1175 Y pY take all branches, once each, in any order⬇⬇ CD47bd dimer c i2

vegf(r!1,r!2,c~r).vegfr2(l1!1,c~r).vegfr2(l1!2,Y1175~Y,c~r) -> vegf(r!1,r!2,c~r).vegfr2(l1!1,c~r).vegfr2(l1!2,Y1175~pY,c~r)

vegf 1r 2r nrp1bd c r vegfr2 1l1 Y1175 Y pY CD47bd dimer c r vegfr2 2l1 Y1175 Y pY take all branches, once each, in any order⬇⬇ CD47bd dimer c r
Dephosphorylation of VEGFR2 species

vegfr2(Y1175~pY,CD47bd,c~s) -> vegfr2(Y1175~Y,CD47bd,c~s)

vegfr2 l1 Y1175 Y pY take one or more branches, once each, in any order⬆⬆ CD47bd dimer c s

vegfr2(Y1175~pY,CD47bd!3,c~s).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~s) -> vegfr2(Y1175~Y,CD47bd!3,c~s).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~s)

vegfr2 l1 Y1175 Y pY take one or more branches, once each, in any order⬆⬆ 3CD47bd dimer c s CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c s

vegfr2(Y1175~pY,CD47bd!3,c~s).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~s) -> vegfr2(Y1175~Y,CD47bd!3,c~s).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~s)

vegfr2 l1 Y1175 Y pY take one or more branches, once each, in any order⬆⬆ 3CD47bd dimer c s CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c s

vegfr2(Y1175~pY,CD47bd,c~i) -> vegfr2(Y1175~Y,CD47bd,c~i)

vegfr2 l1 Y1175 Y pY take one or more branches, once each, in any order⬆⬆ CD47bd dimer c i

vegfr2(Y1175~pY,CD47bd!3,c~i).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i) -> vegfr2(Y1175~Y,CD47bd!3,c~i).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i)

vegfr2 l1 Y1175 Y pY take one or more branches, once each, in any order⬆⬆ 3CD47bd dimer c i CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c i

vegfr2(Y1175~pY,CD47bd!3,c~i).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i) -> vegfr2(Y1175~Y,CD47bd!3,c~i).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i)

vegfr2 l1 Y1175 Y pY take one or more branches, once each, in any order⬆⬆ 3CD47bd dimer c i CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c i

vegfr2(Y1175~pY,CD47bd,c~i2) -> vegfr2(Y1175~Y,CD47bd,c~i2)

vegfr2 l1 Y1175 Y pY take one or more branches, once each, in any order⬆⬆ CD47bd dimer c i2

vegfr2(Y1175~pY,CD47bd!3,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i2) -> vegfr2(Y1175~Y,CD47bd!3,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i2)

vegfr2 l1 Y1175 Y pY take one or more branches, once each, in any order⬆⬆ 3CD47bd dimer c i2 CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c i2

vegfr2(Y1175~pY,CD47bd!3,c~i2).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i2) -> vegfr2(Y1175~Y,CD47bd!3,c~i2).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i2)

vegfr2 l1 Y1175 Y pY take one or more branches, once each, in any order⬆⬆ 3CD47bd dimer c i2 CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c i2

vegfr2(Y1175~pY,c~r) -> vegfr2(Y1175~Y,c~r)

vegfr2 l1 Y1175 Y pY take one or more branches, once each, in any order⬆⬆ CD47bd dimer c r
Internalization s to i

vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,CD47bd,dimer,c~s).vegfr2(l1!2,CD47bd,dimer,c~s) -> vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd,dimer,c~i).vegfr2(l1!2,CD47bd,dimer,c~i)

vegf 1r 2r nrp1bd c s i take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY CD47bd dimer c s i take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd dimer c s i take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,CD47bd,dimer!6,c~s).vegfr2(l1!2,CD47bd,dimer!6,c~s) -> vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd,dimer!6,c~i).vegfr2(l1!2,CD47bd,dimer!6,c~i)

vegf 1r 2r nrp1bd c s i take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY CD47bd 6dimer c s i take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd 6dimer c s i take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,CD47bd!3,dimer,c~s).CD47SIRPa(VEGFR2bd!3,c~s).vegfr2(l1!2,CD47bd,dimer,c~s) -> vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd!3,dimer,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd,dimer,c~i)

vegf 1r 2r nrp1bd c s i take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd dimer c s i take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c s i take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd dimer c s i take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,CD47bd!3,dimer!6,c~s).CD47SIRPa(VEGFR2bd!3,c~s).vegfr2(l1!2,CD47bd,dimer!6,c~s) -> vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd!3,dimer!6,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd,dimer!6,c~i)

vegf 1r 2r nrp1bd c s i take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd 6dimer c s i take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c s i take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd 6dimer c s i take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,CD47bd!3,dimer,c~s).CD47SIRPa(VEGFR2bd!3,c~s).vegfr2(l1!2,CD47bd!4,dimer,c~s).CD47SIRPa(VEGFR2bd!4,c~s) -> vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd!3,dimer,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd!4,dimer,c~i).CD47SIRPa(VEGFR2bd!4,c~i)

vegf 1r 2r nrp1bd c s i take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd dimer c s i take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c s i take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY 4CD47bd dimer c s i take all branches, once each, in any order⬇⬇ CD47SIRPa 4VEGFR2bd TSP1bd Y1 Y pY c s i take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd,c~s).vegfr2(l1!1,CD47bd!3,dimer!6,c~s).CD47SIRPa(VEGFR2bd!3,c~s).vegfr2(l1!2,CD47bd!4,dimer!6,c~s).CD47SIRPa(VEGFR2bd!4,c~s) -> vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd!3,dimer!6,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd!4,dimer!6,c~i).CD47SIRPa(VEGFR2bd!4,c~i)

vegf 1r 2r nrp1bd c s i take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd 6dimer c s i take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c s i take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY 4CD47bd 6dimer c s i take all branches, once each, in any order⬇⬇ CD47SIRPa 4VEGFR2bd TSP1bd Y1 Y pY c s i take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd!9,c~s).NRP1(vegfabd!9,c~s).vegfr2(l1!1,CD47bd,dimer,c~s).vegfr2(l1!2,CD47bd,dimer,c~s) -> vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd,dimer,c~i).vegfr2(l1!2,CD47bd,dimer,c~i)

vegf 1r 2r 9nrp1bd c s i take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c s i take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY CD47bd dimer c s i take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd dimer c s i take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd!9,c~s).NRP1(vegfabd!9,c~s).vegfr2(l1!1,CD47bd!3,dimer,c~s).CD47SIRPa(VEGFR2bd!3,c~s).vegfr2(l1!2,CD47bd,dimer,c~s) -> vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd!3,dimer,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd,dimer,c~i)

vegf 1r 2r 9nrp1bd c s i take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c s i take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd dimer c s i take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c s i take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd dimer c s i take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd!9,c~s).NRP1(vegfabd!9,c~s).vegfr2(l1!1,CD47bd!3,dimer,c~s).CD47SIRPa(VEGFR2bd!3,c~s).vegfr2(l1!2,CD47bd!4,dimer,c~s).CD47SIRPa(VEGFR2bd!4,c~s) -> vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd!3,dimer,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd!4,dimer,c~i).CD47SIRPa(VEGFR2bd!4,c~i)

vegf 1r 2r 9nrp1bd c s i take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c s i take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd dimer c s i take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c s i take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY 4CD47bd dimer c s i take all branches, once each, in any order⬇⬇ CD47SIRPa 4VEGFR2bd TSP1bd Y1 Y pY c s i take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd!9,c~s).NRP1(vegfabd!9,c~s).vegfr2(l1!1,CD47bd,dimer!6,c~s).vegfr2(l1!2,CD47bd,dimer!6,c~s) -> vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd,dimer!6,c~i).vegfr2(l1!2,CD47bd,dimer!6,c~i)

vegf 1r 2r 9nrp1bd c s i take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c s i take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY CD47bd 6dimer c s i take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd 6dimer c s i take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd!9,c~s).NRP1(vegfabd!9,c~s).vegfr2(l1!1,CD47bd!3,dimer!6,c~s).CD47SIRPa(VEGFR2bd!3,c~s).vegfr2(l1!2,CD47bd,dimer!6,c~s) -> vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd!3,dimer!6,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd,dimer!6,c~i)

vegf 1r 2r 9nrp1bd c s i take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c s i take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd 6dimer c s i take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c s i take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd 6dimer c s i take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd!9,c~s).NRP1(vegfabd!9,c~s).vegfr2(l1!1,CD47bd!3,dimer!6,c~s).CD47SIRPa(VEGFR2bd!3,c~s).vegfr2(l1!2,CD47bd!4,dimer!6,c~s).CD47SIRPa(VEGFR2bd!4,c~s) -> vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd!3,dimer!6,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd!4,dimer!6,c~i).CD47SIRPa(VEGFR2bd!4,c~i)

vegf 1r 2r 9nrp1bd c s i take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c s i take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd 6dimer c s i take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c s i take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY 4CD47bd 6dimer c s i take all branches, once each, in any order⬇⬇ CD47SIRPa 4VEGFR2bd TSP1bd Y1 Y pY c s i take all branches, once each, in any order⬇⬇
From i to i2 compartment

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd,dimer,c~i).vegfr2(l1!2,CD47bd,dimer,c~i) <-> vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,CD47bd,dimer,c~i2).vegfr2(l1!2,CD47bd,dimer,c~i2)

vegf 1r 2r nrp1bd c i i2 take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY CD47bd dimer c i i2 take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd dimer c i i2 take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd,dimer!6,c~i).vegfr2(l1!2,CD47bd,dimer!6,c~i) <-> vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,CD47bd,dimer!6,c~i2).vegfr2(l1!2,CD47bd,dimer!6,c~i2)

vegf 1r 2r nrp1bd c i i2 take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY CD47bd 6dimer c i i2 take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd 6dimer c i i2 take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd!3,dimer,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd,dimer,c~i) <-> vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,CD47bd!3,dimer,c~i2).CD47SIRPa(VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd,dimer,c~i2)

vegf 1r 2r nrp1bd c i i2 take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd dimer c i i2 take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c i i2 take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd dimer c i i2 take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd!3,dimer!4,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd,dimer!4,c~i) <-> vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,CD47bd!3,dimer!4,c~i2).CD47SIRPa(VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd,dimer!4,c~i2)

vegf 1r 2r nrp1bd c i i2 take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd 4dimer c i i2 take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c i i2 take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd 4dimer c i i2 take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd!3,dimer,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd!4,dimer,c~i).CD47SIRPa(VEGFR2bd!4,c~i) <-> vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,CD47bd!3,dimer,c~i2).CD47SIRPa(VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd!4,dimer,c~i2).CD47SIRPa(VEGFR2bd!4,c~i2)

vegf 1r 2r nrp1bd c i i2 take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd dimer c i i2 take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c i i2 take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY 4CD47bd dimer c i i2 take all branches, once each, in any order⬇⬇ CD47SIRPa 4VEGFR2bd TSP1bd Y1 Y pY c i i2 take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd,c~i).vegfr2(l1!1,CD47bd!3,dimer!6,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd!4,dimer!6,c~i).CD47SIRPa(VEGFR2bd!4,c~i) <-> vegf(r!1,r!2,nrp1bd,c~i2).vegfr2(l1!1,CD47bd!3,dimer!6,c~i2).CD47SIRPa(VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd!4,dimer!6,c~i2).CD47SIRPa(VEGFR2bd!4,c~i2)

vegf 1r 2r nrp1bd c i i2 take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd 6dimer c i i2 take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c i i2 take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY 4CD47bd 6dimer c i i2 take all branches, once each, in any order⬇⬇ CD47SIRPa 4VEGFR2bd TSP1bd Y1 Y pY c i i2 take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd,dimer,c~i).vegfr2(l1!2,CD47bd,dimer,c~i) <-> vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd,dimer,c~i2).vegfr2(l1!2,CD47bd,dimer,c~i2)

vegf 1r 2r 9nrp1bd c i i2 take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c i i2 take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY CD47bd dimer c i i2 take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd dimer c i i2 take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd,dimer!6,c~i).vegfr2(l1!2,CD47bd,dimer!6,c~i) <-> vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd,dimer!6,c~i2).vegfr2(l1!2,CD47bd,dimer!6,c~i2)

vegf 1r 2r 9nrp1bd c i i2 take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c i i2 take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY CD47bd 6dimer c i i2 take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd 6dimer c i i2 take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd!3,dimer,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd,dimer,c~i) <-> vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer,c~i2).CD47SIRPa(VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd,dimer,c~i2)

vegf 1r 2r 9nrp1bd c i i2 take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c i i2 take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd dimer c i i2 take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c i i2 take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd dimer c i i2 take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd!3,dimer!6,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd,dimer!6,c~i) <-> vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer!6,c~i2).CD47SIRPa(VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd,dimer!6,c~i2)

vegf 1r 2r 9nrp1bd c i i2 take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c i i2 take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd 6dimer c i i2 take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c i i2 take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd 6dimer c i i2 take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd!3,dimer,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd!4,dimer,c~i).CD47SIRPa(VEGFR2bd!4,c~i) <-> vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer,c~i2).CD47SIRPa(VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd!4,dimer,c~i2).CD47SIRPa(VEGFR2bd!4,c~i2)

vegf 1r 2r 9nrp1bd c i i2 take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c i i2 take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd dimer c i i2 take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c i i2 take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY 4CD47bd dimer c i i2 take all branches, once each, in any order⬇⬇ CD47SIRPa 4VEGFR2bd TSP1bd Y1 Y pY c i i2 take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd!9,c~i).NRP1(vegfabd!9,c~i).vegfr2(l1!1,CD47bd!3,dimer!6,c~i).CD47SIRPa(VEGFR2bd!3,c~i).vegfr2(l1!2,CD47bd!4,dimer!6,c~i).CD47SIRPa(VEGFR2bd!4,c~i) <-> vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer!6,c~i2).CD47SIRPa(VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd!4,dimer!6,c~i2).CD47SIRPa(VEGFR2bd!4,c~i2)

vegf 1r 2r 9nrp1bd c i i2 take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c i i2 take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd 6dimer c i i2 take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c i i2 take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY 4CD47bd 6dimer c i i2 take all branches, once each, in any order⬇⬇ CD47SIRPa 4VEGFR2bd TSP1bd Y1 Y pY c i i2 take all branches, once each, in any order⬇⬇
From internalized compartment to the recycling compartment

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd,dimer,c~i2).vegfr2(l1!2,CD47bd,dimer,c~i2) -> vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,CD47bd,dimer,c~r).vegfr2(l1!2,CD47bd,dimer,c~r)

vegf 1r 2r 9nrp1bd c i2 r take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c i2 r take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY CD47bd dimer c i2 r take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd dimer c i2 r take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd,dimer!6,c~i2).vegfr2(l1!2,CD47bd,dimer!6,c~i2) -> vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,CD47bd,dimer!6,c~r).vegfr2(l1!2,CD47bd,dimer!6,c~r)

vegf 1r 2r 9nrp1bd c i2 r take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c i2 r take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY CD47bd 6dimer c i2 r take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd 6dimer c i2 r take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd,dimer,c~i2) -> vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,CD47bd!3,dimer,c~r).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~r).vegfr2(l1!2,CD47bd,dimer,c~r)

vegf 1r 2r 9nrp1bd c i2 r take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c i2 r take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd dimer c i2 r take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c i2 r take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd dimer c i2 r take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer!6,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd,dimer!6,c~i2) -> vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,CD47bd!3,dimer!6,c~r).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~r).vegfr2(l1!2,CD47bd,dimer!6,c~r)

vegf 1r 2r 9nrp1bd c i2 r take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c i2 r take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd 6dimer c i2 r take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c i2 r take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd 6dimer c i2 r take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd!4,dimer,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!4,c~i2) -> vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,CD47bd!3,dimer,c~r).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~r).vegfr2(l1!2,CD47bd!4,dimer,c~r).CD47SIRPa(TSP1bd,VEGFR2bd!4,c~r)

vegf 1r 2r 9nrp1bd c i2 r take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c i2 r take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd dimer c i2 r take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c i2 r take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY 4CD47bd dimer c i2 r take all branches, once each, in any order⬇⬇ CD47SIRPa 4VEGFR2bd TSP1bd Y1 Y pY c i2 r take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer!6,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd!4,dimer!6,c~i2).CD47SIRPa(TSP1bd,VEGFR2bd!4,c~i2) -> vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,CD47bd!3,dimer!6,c~r).CD47SIRPa(TSP1bd,VEGFR2bd!3,c~r).vegfr2(l1!2,CD47bd!4,dimer!6,c~r).CD47SIRPa(TSP1bd,VEGFR2bd!4,c~r)

vegf 1r 2r 9nrp1bd c i2 r take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c i2 r take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd 6dimer c i2 r take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c i2 r take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY 4CD47bd 6dimer c i2 r take all branches, once each, in any order⬇⬇ CD47SIRPa 4VEGFR2bd TSP1bd Y1 Y pY c i2 r take all branches, once each, in any order⬇⬇
####################################################################################################################################################################################################

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer,c~i2).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd,dimer,c~i2) -> vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,CD47bd!3,dimer,c~r).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~r).vegfr2(l1!2,CD47bd,dimer,c~r)

vegf 1r 2r 9nrp1bd c i2 r take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c i2 r take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd dimer c i2 r take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c i2 r take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd dimer c i2 r take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer!6,c~i2).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd,dimer!6,c~i2) -> vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,CD47bd!3,dimer!6,c~r).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~r).vegfr2(l1!2,CD47bd,dimer!6,c~r)

vegf 1r 2r 9nrp1bd c i2 r take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c i2 r take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd 6dimer c i2 r take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c i2 r take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY CD47bd 6dimer c i2 r take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer,c~i2).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd!4,dimer,c~i2).CD47SIRPa(VEGFR2bd!4,c~i2) -> vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,CD47bd!3,dimer,c~r).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~r).vegfr2(l1!2,CD47bd!4,dimer,c~r).CD47SIRPa(VEGFR2bd!4,c~r)

vegf 1r 2r 9nrp1bd c i2 r take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c i2 r take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd dimer c i2 r take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c i2 r take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY 4CD47bd dimer c i2 r take all branches, once each, in any order⬇⬇ CD47SIRPa 4VEGFR2bd TSP1bd Y1 Y pY c i2 r take all branches, once each, in any order⬇⬇

vegf(r!1,r!2,nrp1bd!9,c~i2).NRP1(vegfabd!9,c~i2).vegfr2(l1!1,CD47bd!3,dimer!6,c~i2).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~i2).vegfr2(l1!2,CD47bd!4,dimer!6,c~i2).CD47SIRPa(VEGFR2bd!4,c~i2) -> vegf(r!1,r!2,nrp1bd!9,c~r).NRP1(vegfabd!9,c~r).vegfr2(l1!1,CD47bd!3,dimer!6,c~r).CD47SIRPa(TSP1bd!+,VEGFR2bd!3,c~r).vegfr2(l1!2,CD47bd!4,dimer!6,c~r).CD47SIRPa(VEGFR2bd!4,c~r)

vegf 1r 2r 9nrp1bd c i2 r take all branches, once each, in any order⬇⬇ NRP1 9vegfabd c i2 r take all branches, once each, in any order⬇⬇ vegfr2 1l1 Y1175 Y pY 3CD47bd 6dimer c i2 r take all branches, once each, in any order⬇⬇ CD47SIRPa 3VEGFR2bd TSP1bd Y1 Y pY c i2 r take all branches, once each, in any order⬇⬇ vegfr2 2l1 Y1175 Y pY 4CD47bd 6dimer c i2 r take all branches, once each, in any order⬇⬇ CD47SIRPa 4VEGFR2bd TSP1bd Y1 Y pY c i2 r take all branches, once each, in any order⬇⬇
#####################################################################################################################################################################################################Recycling r to s

vegfr2(l1,Y1175~Y,CD47bd,dimer,c~r) -> vegfr2(l1,Y1175~Y,CD47bd,dimer,c~s)

vegfr2 l1 Y1175 Y CD47bd dimer c s r take one or more branches, once each, in any order⬆⬆

NRP1(vegfabd,c~r) -> NRP1(vegfabd,c~s)

NRP1 vegfabd c s r take one or more branches, once each, in any order⬆⬆

CD47SIRPa(TSP1bd,VEGFR2bd,c~r) -> CD47SIRPa(TSP1bd,VEGFR2bd,c~s)

CD47SIRPa VEGFR2bd TSP1bd Y1 Y pY c s r take one or more branches, once each, in any order⬆⬆

vegfr2(dimer!6,c~r).vegfr2(dimer!6,c~r) -> vegfr2(dimer,c~r) + vegfr2(dimer,c~r)

vegfr2 l1 Y1175 Y pY CD47bd 6 ⬆dimer c r vegfr2 l1 Y1175 Y pY CD47bd 6 ⬆dimer c r

vegfr2(CD47bd!3,c~r).CD47SIRPa(VEGFR2bd!3,c~r) -> vegfr2(CD47bd,c~r) + CD47SIRPa(VEGFR2bd,c~r)

vegfr2 l1 Y1175 Y pY 3 ⬆CD47bd dimer c r CD47SIRPa 3 ⬆VEGFR2bd TSP1bd Y1 Y pY c r
Receptor degradationwith TSP1Single receptorR2 receptor synthesisI() -> I() + CD47SIRPa(VEGFR2bd,TSP1bd,Y1~Y,c~s) ksingleR2syn*CD47free_0

vegfr2(l1,CD47bd,dimer,c~s) <-> vegfr2(l1,CD47bd,dimer,c~i)

vegfr2 l1 Y1175 Y pY CD47bd dimer c s i take all branches, once each, in any order⬇⬇

vegfr2(l1,CD47bd!1,dimer,c~s).CD47SIRPa(VEGFR2bd!1,c~s) <-> vegfr2(l1,CD47bd!1,dimer,c~i).CD47SIRPa(VEGFR2bd!1,c~i)

vegfr2 l1 Y1175 Y pY 1CD47bd dimer c s i take all branches, once each, in any order⬇⬇ CD47SIRPa 1VEGFR2bd TSP1bd Y1 Y pY c s i take all branches, once each, in any order⬇⬇

vegfr2(l1,CD47bd,dimer!3,c~s).vegfr2(l1,CD47bd,dimer!3,c~s) <-> vegfr2(l1,CD47bd,dimer!3,c~i).vegfr2(l1,CD47bd,dimer!3,c~i)

vegfr2 l1 Y1175 Y pY CD47bd 3dimer c s i take all branches, once each, in any order⬇⬇ vegfr2 l1 Y1175 Y pY CD47bd 3dimer c s i take all branches, once each, in any order⬇⬇

vegfr2(l1,CD47bd!1,dimer!3,c~s).CD47SIRPa(VEGFR2bd!1,c~s).vegfr2(l1,CD47bd,dimer!3,c~s) <-> vegfr2(l1,CD47bd!1,dimer!3,c~i).CD47SIRPa(VEGFR2bd!1,c~i).vegfr2(l1,CD47bd,dimer!3,c~i)

vegfr2 l1 Y1175 Y pY 1CD47bd 3dimer c s i take all branches, once each, in any order⬇⬇ CD47SIRPa 1VEGFR2bd TSP1bd Y1 Y pY c s i take all branches, once each, in any order⬇⬇ vegfr2 l1 Y1175 Y pY CD47bd 3dimer c s i take all branches, once each, in any order⬇⬇

vegfr2(l1,CD47bd!1,dimer!3,c~s).CD47SIRPa(VEGFR2bd!1,c~s).vegfr2(l1,CD47bd!2,dimer!3,c~s).CD47SIRPa(VEGFR2bd!2,c~s) <-> vegfr2(l1,CD47bd!1,dimer!3,c~i).CD47SIRPa(VEGFR2bd!1,c~i).vegfr2(l1,CD47bd!2,dimer!3,c~i).CD47SIRPa(VEGFR2bd!2,c~i)

vegfr2 l1 Y1175 Y pY 1CD47bd 3dimer c s i take all branches, once each, in any order⬇⬇ CD47SIRPa 1VEGFR2bd TSP1bd Y1 Y pY c s i take all branches, once each, in any order⬇⬇ vegfr2 l1 Y1175 Y pY 2CD47bd 3dimer c s i take all branches, once each, in any order⬇⬇ CD47SIRPa 2VEGFR2bd TSP1bd Y1 Y pY c s i take all branches, once each, in any order⬇⬇
Activating PLCgamma

PLCgamma(Yplc~Y) + vegfr2(Y1175~pY,c~s) -> PLCgamma(Yplc~pY) + vegfr2(Y1175~pY,c~s)

PLCgamma Yplc Y pY take all branches, once each, in any order⬇⬇ vegfr2 l1 Y1175 pY CD47bd dimer c s

PLCgamma(Yplc~Y) + vegfr2(Y1175~pY,c~i) -> PLCgamma(Yplc~pY) + vegfr2(Y1175~pY,c~i)

PLCgamma Yplc Y pY take all branches, once each, in any order⬇⬇ vegfr2 l1 Y1175 pY CD47bd dimer c i

PLCgamma(Yplc~Y) + vegfr2(Y1175~pY,c~i2) -> PLCgamma(Yplc~pY) + vegfr2(Y1175~pY,c~i2)

PLCgamma Yplc Y pY take all branches, once each, in any order⬇⬇ vegfr2 l1 Y1175 pY CD47bd dimer c i2

PLCgamma(Yplc~pY) -> PLCgamma(Yplc~Y)

PLCgamma Yplc Y pY take one or more branches, once each, in any order⬆⬆
IP3 and DAG generation

Calcium_cyto(bd) + CaF(cabd) <-> Calcium_cyto(bd!1).CaF(cabd!1)

Calcium_cyto 1 ⬆⬇bd CaF 1 ⬆⬇cabd
Calcium binding to CaMPI3K/AKT pathwaybinding of TSAd (Tcell specific adaptor molecule)

TSADSrc(Y1~Y) + vegfr2(Y1175~pY!?,c~s) -> TSADSrc(Y1~pY) + vegfr2(Y1175~pY!?,c~s)

TSADSrc Y1 Y pY take all branches, once each, in any order⬇⬇ vegfr2 l1 Y1175 pY CD47bd dimer c s

TSADSrc(Y1~Y) + vegfr2(Y1175~pY!?,c~i) -> TSADSrc(Y1~pY) + vegfr2(Y1175~pY!?,c~i)

TSADSrc Y1 Y pY take all branches, once each, in any order⬇⬇ vegfr2 l1 Y1175 pY CD47bd dimer c i

TSADSrc(Y1~Y) + vegfr2(Y1175~pY!?,c~i2) -> TSADSrc(Y1~pY) + vegfr2(Y1175~pY!?,c~i2)

TSADSrc Y1 Y pY take all branches, once each, in any order⬇⬇ vegfr2 l1 Y1175 pY CD47bd dimer c i2

TSADSrc(Y1~pY) -> TSADSrc(Y1~Y)

TSADSrc Y1 Y pY take one or more branches, once each, in any order⬆⬆
Activation of Axl by Src

TSADSrc(Y1~pY) + Axl(Ysrc~Y) -> TSADSrc(Y1~pY) + Axl(Ysrc~pY)

TSADSrc Y1 pY Axl Ysrc Y pY take all branches, once each, in any order⬇⬇ Yaxl Y pY

Axl(Ysrc~pY,Yaxl~Y) -> Axl(Ysrc~pY,Yaxl~pY)

Axl Ysrc pY Yaxl Y pY take all branches, once each, in any order⬇⬇

Axl(Yaxl~pY) -> Axl(Yaxl~Y)

Axl Ysrc Y pY Yaxl Y pY take one or more branches, once each, in any order⬆⬆

Axl(Ysrc~pY) -> Axl(Ysrc~Y)

Axl Ysrc Y pY take one or more branches, once each, in any order⬆⬆ Yaxl Y pY
Binding of PI3K to activated Axl

PI3K(state~inactive) + Axl(Yaxl~pY) -> PI3K(state~active) + Axl(Yaxl~pY)

PI3K state active inactive take one or more branches, once each, in any order⬆⬆ Axl Ysrc Y pY Yaxl pY

PI3K(state~active) -> PI3K(state~inactive)

PI3K state active inactive take all branches, once each, in any order⬇⬇

PDK1(PHpdk1) + PI(PIsite~4P) <-> PDK1(PHpdk1!1).PI(PIsite~4P!1)

PDK1 1 ⬆⬇PHpdk1 aktbd PI PIsite 1 ⬆⬇4P

AKT(PHakt) + PI(PIsite~4P) <-> AKT(PHakt!1).PI(PIsite~4P!1)

AKT 1 ⬆⬇PHakt T308 S pS S473 S pS PI PIsite 1 ⬆⬇4P

AKT(PHakt!+,S473~S) -> AKT(PHakt!+,S473~pS)

AKT PHakt T308 S pS S473 S pS take all branches, once each, in any order⬇⬇

AKT(S473~pS) -> AKT(S473~S)

AKT PHakt T308 S pS S473 S pS take one or more branches, once each, in any order⬆⬆

AKT(T308~pS) -> AKT(T308~S)

AKT PHakt T308 S pS take one or more branches, once each, in any order⬆⬆ S473 S pS
eNOS activation by Ca/CaM and pAKT

CaM(NCaM!+,NCaM!+,CCaM!+,CCaM!+,CaMtargetbd) + eNOS(CaMBD) <-> CaM(NCaM!+,NCaM!+,CCaM!+,CCaM!+,CaMtargetbd!1).eNOS(CaMBD!1)

CaM NCaM NCaM CCaM CCaM 1 ⬆⬇CaMtargetbd eNOS 1 ⬆⬇CaMBD S1177 S pS cav1BD

eNOS(CaMBD!+,cav1BD!1).caveolin1(eNOSbd!1) -> eNOS(CaMBD!+,cav1BD) + caveolin1(eNOSbd)

eNOS CaMBD S1177 S pS 1 ⬆cav1BD caveolin1 1 ⬆eNOSbd

eNOS(cav1BD!1,S1177~pS).caveolin1(eNOSbd!1) -> eNOS(cav1BD,S1177~pS) + caveolin1(eNOSbd)

eNOS CaMBD S1177 pS 1 ⬆cav1BD caveolin1 1 ⬆eNOSbd

eNOS(CaMBD,cav1BD,S1177~S) + caveolin1(eNOSbd) -> eNOS(CaMBD,cav1BD!1,S1177~S).caveolin1(eNOSbd!1)

eNOS CaMBD S1177 S 1 ⬇cav1BD caveolin1 1 ⬇eNOSbd

eNOS(CaMBD!+,S1177~S) + AKT(T308~pS,S473~pS) -> eNOS(CaMBD!+,S1177~pS) + AKT(T308~pS,S473~pS)

eNOS CaMBD S1177 S pS take all branches, once each, in any order⬇⬇ cav1BD AKT PHakt T308 pS S473 pS

eNOS(S1177~pS) -> eNOS(S1177~S)

eNOS CaMBD S1177 S pS take one or more branches, once each, in any order⬆⬆ cav1BD
TSP1 binding to CD47SIRPa

vegfr2(CD47bd,c~s) + CD47SIRPa(VEGFR2bd,c~s) -> vegfr2(CD47bd!1,c~s).CD47SIRPa(VEGFR2bd!1,c~s)

vegfr2 l1 Y1175 Y pY 1 ⬇CD47bd dimer c s CD47SIRPa 1 ⬇VEGFR2bd TSP1bd Y1 Y pY c s

PKC(CalciumBD) + Calcium_cyto(bd) <-> PKC(CalciumBD!1).Calcium_cyto(bd!1)

PKC 1 ⬆⬇CalciumBD DAGBD Calcium_cyto 1 ⬆⬇bd

PKC(DAGBD) + DAG(pkcbd) <-> PKC(DAGBD!1).DAG(pkcbd!1)

PKC CalciumBD 1 ⬆⬇DAGBD DAG 1 ⬆⬇pkcbd

CIB1(EF1) + Calcium_cyto(bd) <-> CIB1(EF1!1).Calcium_cyto(bd!1)

CIB1 1 ⬆⬇EF1 EF2 sk1bd location cytosol membrane Calcium_cyto 1 ⬆⬇bd

CIB1(EF2) + Calcium_cyto(bd) <-> CIB1(EF2!1).Calcium_cyto(bd!1)

CIB1 EF1 1 ⬆⬇EF2 sk1bd location cytosol membrane Calcium_cyto 1 ⬆⬇bd

CIB1(EF1!+,EF2!+,sk1bd,location~cytosol) + SphK(CIB1bd,Serk~pS) <-> CIB1(EF1!+,EF2!+,sk1bd!1,location~cytosol).SphK(CIB1bd!1,Serk~pS)

CIB1 EF1 EF2 1 ⬆⬇sk1bd location cytosol SphK 1 ⬆⬇CIB1bd Serk pS

CIB1(EF1!+,EF2!+,sk1bd!+,location~cytosol) <-> CIB1(EF1!+,EF2!+,sk1bd!+,location~membrane)

CIB1 EF1 EF2 sk1bd location cytosol membrane take all branches, once each, in any order⬇⬇

CIB1(EF1,EF2,location~membrane) -> CIB1(EF1,EF2,location~cytosol)

CIB1 EF1 EF2 sk1bd location cytosol membrane take one or more branches, once each, in any order⬆⬆

SphK(Serk~pS) -> SphK(Serk~S)

SphK CIB1bd Serk S pS take one or more branches, once each, in any order⬆⬆

Raf(Spkc~pS) -> Raf(Spkc~S)

Raf mekbd rasbd Y1Y2 Y pY Spkc S pS take one or more branches, once each, in any order⬆⬆

Raf(rasbd) + RasGTP(rafbd) <-> Raf(rasbd!1).RasGTP(rafbd!1)

Raf mekbd 1 ⬆⬇rasbd Y1Y2 Y pY Spkc S pS RasGTP 1 ⬆⬇rafbd

Raf(rasbd!1,Y1Y2~Y).RasGTP(rafbd!1) -> Raf(rasbd!1,Y1Y2~pY).RasGTP(rafbd!1)

Raf mekbd 1rasbd Y1Y2 Y pY take all branches, once each, in any order⬇⬇ Spkc S pS RasGTP 1rafbd

Raf(Y1Y2~pY) -> Raf(Y1Y2~Y)

Raf mekbd rasbd Y1Y2 Y pY take one or more branches, once each, in any order⬆⬆ Spkc S pS

MEK12(S1~pS) -> MEK12(S1~S)

MEK12 bd S1 S pS take one or more branches, once each, in any order⬆⬆ S2 S pS

MEK12(S2~pS) -> MEK12(S2~S)

MEK12 bd S1 S pS S2 S pS take one or more branches, once each, in any order⬆⬆

ERK1(S1~pS) -> ERK1(S1~S)

ERK1 MEK12bd S1 S pS take one or more branches, once each, in any order⬆⬆

ERK2(S2~pS) -> ERK2(S2~S)

ERK2 MEK12bd S2 S pS take one or more branches, once each, in any order⬆⬆