Molecules

Tie2(tie1bs,loc~s~i~j~sol,veptpbs,pY~p~dp,ang1bs,ang2bs)

Tie2 tie1bs loc s i j sol veptpbs pY p dp ang1bs ang2bs

Tie1(pY~dp~p,tie2bs,loc~s~i~j~sol)

Tie1 pY dp p tie2bs loc s i j sol

Ang1_4(tie2bs,tie2bs,tie2bs,tie2bs)

Ang1_4 tie2bs tie2bs tie2bs tie2bs

Ang2_2(tie2bs,tie2bs)

Ang2_2 tie2bs tie2bs

Ang2_3(tie2bs,tie2bs,tie2bs)

Ang2_3 tie2bs tie2bs tie2bs

Ang2_4(tie2bs,tie2bs,tie2bs,tie2bs)

Ang2_4 tie2bs tie2bs tie2bs tie2bs

VEPTP(tie2bs)

VEPTP tie2bs

PTEN(PIP3docking)

PTEN PIP3docking

PI(PIsite~3P~4P)

PI PIsite 3P 4P

PI3K(state~active~inactive)

PI3K state active inactive

Akt(PHakt,T308~S~pS,S473~S~pS)

Akt PHakt T308 S pS S473 S pS

PDK1(PHpdk1,aktbd)

PDK1 PHpdk1 aktbd

RhoA(G~GDP~GTP,mDiabs)

RhoA G GDP GTP mDiabs

mDia(RhoAbs,srcbs)

mDia RhoAbs srcbs

Src(mDiabs,Y1~Y~pY)

Src mDiabs Y1 Y pY

VECadherin(S665~S~pS,c~j~i)

VECadherin S665 S pS c j i

ABIN2(state~inactive~active)

ABIN2 state inactive active

I()

I

Trash()

Trash

Species

Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs,ang2bs)

Tie2 tie1bs loc s veptpbs pY dp ang1bs ang2bs

Ang1_4(tie2bs,tie2bs,tie2bs,tie2bs)

Ang1_4 tie2bs tie2bs tie2bs tie2bs

Ang2_2(tie2bs,tie2bs)

Ang2_2 tie2bs tie2bs

Ang2_3(tie2bs,tie2bs,tie2bs)

Ang2_3 tie2bs tie2bs tie2bs

Ang2_4(tie2bs,tie2bs,tie2bs,tie2bs)

Ang2_4 tie2bs tie2bs tie2bs tie2bs

VEPTP(tie2bs)

VEPTP tie2bs

Tie2(tie1bs,loc~sol,veptpbs,pY~dp,ang1bs,ang2bs)

Tie2 tie1bs loc sol veptpbs pY dp ang1bs ang2bs

Tie1(pY~dp,loc~sol,tie2bs)

Tie1 pY dp loc sol tie2bs

Tie1(pY~dp,loc~s,tie2bs)

Tie1 pY dp loc s tie2bs

Tie1(pY~dp,loc~s,tie2bs!1).Tie2(tie1bs!1,loc~s,veptpbs,pY~dp,ang1bs,ang2bs)

Tie1 pY dp loc s tie2bs Tie2 tie1bs loc s veptpbs pY dp ang1bs ang2bs

PTEN(PIP3docking)

PTEN PIP3docking

PI(PIsite~3P)

PI PIsite 3P

PI3K(state~inactive)

PI3K state inactive

Akt(PHakt,T308~S,S473~S)

Akt PHakt T308 S S473 S

PDK1(PHpdk1,aktbd)

PDK1 PHpdk1 aktbd

RhoA(G~GDP,mDiabs)

RhoA G GDP mDiabs

mDia(RhoAbs,srcbs)

mDia RhoAbs srcbs

Src(mDiabs,Y1~Y)

Src mDiabs Y1 Y

VECadherin(S665~S,c~j)

VECadherin S665 S c j

ABIN2(state~inactive)

ABIN2 state inactive

I()

I

Trash()

Trash

Observables

pTie2 Tie2(pY~p)

Tie2 ?tie1bs loc s i j ?sol ?veptpbs pY p ?ang1bs ?ang2bs

intTie2 Tie2(loc~i)

Tie2 ?tie1bs loc i ?veptpbs pY p ?dp ?ang1bs ?ang2bs

surfTie2 Tie2(loc~s)

Tie2 ?tie1bs loc s ?veptpbs pY p ?dp ?ang1bs ?ang2bs

psurfTie2 Tie2(loc~s,pY~p)

Tie2 ?tie1bs loc s ?veptpbs pY p ?ang1bs ?ang2bs

pintTie2 Tie2(loc~i,pY~p)

Tie2 ?tie1bs loc i ?veptpbs pY p ?ang1bs ?ang2bs

totalTie2 Tie2

Tie2 ?tie1bs loc s i j ?sol ?veptpbs pY p ?dp ?ang1bs ?ang2bs

sTie2 Tie2(loc~sol)

Tie2 ?tie1bs loc sol ?veptpbs pY p ?dp ?ang1bs ?ang2bs

Tie1Tie2 Tie1(pY~dp,loc~s,tie2bs!+)

Tie1 pY dp tie2bs loc s

surfTie1 Tie1(pY~dp,loc~s,tie2bs)

Tie1 pY dp tie2bs loc s

sTie1 Tie1(loc~sol)

Tie1 pY dp ?p ?tie2bs loc sol

jTie2 Tie2(loc~j)

Tie2 ?tie1bs loc j ?veptpbs pY p ?dp ?ang1bs ?ang2bs

tsurfTie1 Tie1(loc~s)

Tie1 pY dp ?p ?tie2bs loc s

jTie1 Tie1(loc~j)

Tie1 pY dp ?p ?tie2bs loc j

freepip2 PI(PIsite~3P)

PI PIsite 3P

freepip3 PI(PIsite~4P)

PI PIsite 4P

ppAkt Akt(T308~pS,S473~pS)

Akt ?PHakt T308 pS S473 pS

freeSrc Src(mDiabs)

Src mDiabs Y1 Y ?pY

pSrc Src(Y1~pY)

Src ?mDiabs Y1 pY

pVECadherin VECadherin(S665~pS)

VECadherin S665 pS c j ?i

aABIN2 ABIN2(state~active)

ABIN2 state active

totalAkt Akt

Akt ?PHakt T308 S ?pS S473 S ?pS

RhoAGTP RhoA(G~GTP)

RhoA G GTP ?mDiabs

RhoAmDia mDia(RhoAbs!+)

mDia RhoAbs ?srcbs

mDiaSrc Src(mDiabs!+)

Src mDiabs Y1 Y ?pY

totalTie1 Tie1

Tie1 pY dp ?p ?tie2bs loc s i j ?sol

Reaction Rules


Ang1 Binding (ligand-induced)
1

Ang1_4(tie2bs,tie2bs,tie2bs,tie2bs) + Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs,ang2bs) <-> Ang1_4(tie2bs!1,tie2bs,tie2bs,tie2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs!1,ang2bs)

Ang1_4 ⬇⬆tie2bs tie2bs tie2bs tie2bs ⬇⬆ Tie2 tie1bs loc s veptpbs pY dp ⬇⬆ang1bs ang2bs

2

Ang1_4(tie2bs!1,tie2bs,tie2bs,tie2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs!1,ang2bs) + Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs,ang2bs) <-> Ang1_4(tie2bs!1,tie2bs!2,tie2bs,tie2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs!1,ang2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs!2,ang2bs)

Ang1_4 tie2bs ⬇⬆tie2bs tie2bs tie2bs Tie2 tie1bs loc s veptpbs pY dp ang1bs ang2bs ⬇⬆ Tie2 tie1bs loc s veptpbs pY dp ⬇⬆ang1bs ang2bs

3

Ang1_4(tie2bs!1,tie2bs!2,tie2bs,tie2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs!1,ang2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs!2,ang2bs) + Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs,ang2bs) <-> Ang1_4(tie2bs!1,tie2bs!2,tie2bs!3,tie2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs!1,ang2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs!2,ang2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs!3,ang2bs)

Ang1_4 tie2bs tie2bs ⬇⬆tie2bs tie2bs Tie2 tie1bs loc s veptpbs pY dp ang1bs ang2bs Tie2 tie1bs loc s veptpbs pY dp ang1bs ang2bs ⬇⬆ Tie2 tie1bs loc s veptpbs pY dp ⬇⬆ang1bs ang2bs

4

Ang1_4(tie2bs!1,tie2bs!2,tie2bs!3,tie2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs!1,ang2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs!2,ang2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs!3,ang2bs) + Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs,ang2bs) <-> Ang1_4(tie2bs!1,tie2bs!2,tie2bs!3,tie2bs!4).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs!1,ang2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs!2,ang2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs!3,ang2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang1bs!4,ang2bs)

Ang1_4 tie2bs tie2bs tie2bs ⬇⬆tie2bs Tie2 tie1bs loc s veptpbs pY dp ang1bs ang2bs Tie2 tie1bs loc s veptpbs pY dp ang1bs ang2bs Tie2 tie1bs loc s veptpbs pY dp ang1bs ang2bs ⬇⬆ Tie2 tie1bs loc s veptpbs pY dp ⬇⬆ang1bs ang2bs

Ang2 Binding
dimer
5

Ang2_2(tie2bs,tie2bs) + Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs,ang1bs) <-> Ang2_2(tie2bs!1,tie2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!1,ang1bs)

Ang2_2 ⬇⬆tie2bs tie2bs ⬇⬆ Tie2 tie1bs loc s veptpbs pY dp ang1bs ⬇⬆ang2bs

6

Ang2_2(tie2bs!1,tie2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!1,ang1bs) + Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs,ang1bs) <-> Ang2_2(tie2bs!1,tie2bs!2).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!1,ang1bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!2,ang1bs)

Ang2_2 tie2bs ⬇⬆tie2bs Tie2 tie1bs loc s veptpbs pY dp ang1bs ang2bs ⬇⬆ Tie2 tie1bs loc s veptpbs pY dp ang1bs ⬇⬆ang2bs

trimer
7

Ang2_3(tie2bs,tie2bs,tie2bs) + Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs,ang1bs) <-> Ang2_3(tie2bs!1,tie2bs,tie2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!1,ang1bs)

Ang2_3 ⬇⬆tie2bs tie2bs tie2bs ⬇⬆ Tie2 tie1bs loc s veptpbs pY dp ang1bs ⬇⬆ang2bs

8

Ang2_3(tie2bs!1,tie2bs,tie2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!1,ang1bs) + Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs,ang1bs) <-> Ang2_3(tie2bs!1,tie2bs!2,tie2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!1,ang1bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!2,ang1bs)

Ang2_3 tie2bs ⬇⬆tie2bs tie2bs Tie2 tie1bs loc s veptpbs pY dp ang1bs ang2bs ⬇⬆ Tie2 tie1bs loc s veptpbs pY dp ang1bs ⬇⬆ang2bs

9

Ang2_3(tie2bs!1,tie2bs!2,tie2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!1,ang1bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!2,ang1bs) + Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs,ang1bs) <-> Ang2_3(tie2bs!1,tie2bs!2,tie2bs!3).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!1,ang1bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!2,ang1bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!3,ang1bs)

Ang2_3 tie2bs tie2bs ⬇⬆tie2bs Tie2 tie1bs loc s veptpbs pY dp ang1bs ang2bs Tie2 tie1bs loc s veptpbs pY dp ang1bs ang2bs ⬇⬆ Tie2 tie1bs loc s veptpbs pY dp ang1bs ⬇⬆ang2bs

tetramer
10

Ang2_4(tie2bs,tie2bs,tie2bs,tie2bs) + Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs,ang1bs) <-> Ang2_4(tie2bs!1,tie2bs,tie2bs,tie2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!1,ang1bs)

Ang2_4 ⬇⬆tie2bs tie2bs tie2bs tie2bs ⬇⬆ Tie2 tie1bs loc s veptpbs pY dp ang1bs ⬇⬆ang2bs

11

Ang2_4(tie2bs!1,tie2bs,tie2bs,tie2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!1,ang1bs) + Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs,ang1bs) <-> Ang2_4(tie2bs!1,tie2bs!2,tie2bs,tie2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!1,ang1bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!2,ang1bs)

Ang2_4 tie2bs ⬇⬆tie2bs tie2bs tie2bs Tie2 tie1bs loc s veptpbs pY dp ang1bs ang2bs ⬇⬆ Tie2 tie1bs loc s veptpbs pY dp ang1bs ⬇⬆ang2bs

12

Ang2_4(tie2bs!1,tie2bs!2,tie2bs,tie2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!1,ang1bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!2,ang1bs) + Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs,ang1bs) <-> Ang2_4(tie2bs!1,tie2bs!2,tie2bs!3,tie2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!1,ang1bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!2,ang1bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!3,ang1bs)

Ang2_4 tie2bs tie2bs ⬇⬆tie2bs tie2bs Tie2 tie1bs loc s veptpbs pY dp ang1bs ang2bs Tie2 tie1bs loc s veptpbs pY dp ang1bs ang2bs ⬇⬆ Tie2 tie1bs loc s veptpbs pY dp ang1bs ⬇⬆ang2bs

13

Ang2_4(tie2bs!1,tie2bs!2,tie2bs!3,tie2bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!1,ang1bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!2,ang1bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!3,ang1bs) + Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs,ang1bs) <-> Ang2_4(tie2bs!1,tie2bs!2,tie2bs!3,tie2bs!4).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!1,ang1bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!2,ang1bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!3,ang1bs).Tie2(tie1bs,loc~s,veptpbs,pY~dp,ang2bs!4,ang1bs)

Ang2_4 tie2bs tie2bs tie2bs ⬇⬆tie2bs Tie2 tie1bs loc s veptpbs pY dp ang1bs ang2bs Tie2 tie1bs loc s veptpbs pY dp ang1bs ang2bs Tie2 tie1bs loc s veptpbs pY dp ang1bs ang2bs ⬇⬆ Tie2 tie1bs loc s veptpbs pY dp ang1bs ⬇⬆ang2bs