Saved BNGL Diagrams

Molecules

R(p,a)

T(1,2,3)

Species

R(p,a)

T(1,2,3)

Observables

MonomerReceptor R(p,a)

Molecules DimerReceptor R(p!0,a).R(p!0,a), R(a!0,p).R(a!0,p)
Molecules AggregatedReceptor R(p!0,a!0)

freeTNF T(1,2,3)

TNF1R T(1!+,2,3)

TNF1R T(1,2!+,3)

TNF1R T(1,2,3!+)

TNF2R T(1!+,2!+,3)

TNF2R T(1!+,2,3!+)

TNF2R T(1,2!+,3!+)

TNF3R T(1!+,2!+,3!+)

Molecules Aggregate2TNF T(1!+,2!+,3).R(p!+).R(p!+), T(1!+,2,3!+).R(p!+).R(p!+), T(1,2!+,3!+).R(p!+).R(p!+)
Molecules Aggregate3TNF T(1!+,2!+,3!+).R(p!+).R(p!+).R(p!+)
Molecules NoAggregate3TNF T(1!+,2!+,3!+).R(p).R(p).R(p)

Reaction Rules

Receptor dimerization parallel
1: R(p) + R(p) <-> R(p!0).R(p!0) kp, koff
Receptor dimerization antiparallel
2: R(a) + R(a) <-> R(a!0).R(a!0) ka, koff
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TNF reactions
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First TNF binding event

T(1,2,3) + R(a) <-> T(1!1,2,3).R(a!1)

T(1,2,3) + R(a) <-> T(1,2!1,3).R(a!1)

T(1,2,3) + R(a) <-> T(1,2,3!1).R(a!1)

Second TNF binding event

T(1!+,2,3) + R(a) <-> T(1!+,2!1,3).R(a!1)

T(1!+,2,3) + R(a) <-> T(1!+,2,3!1).R(a!1)

T(1,2!+,3) + R(a) <-> T(1!1,2!+,3).R(a!1)

T(1,2!+,3) + R(a) <-> T(1,2!+,3!1).R(a!1)

T(1,2,3!+) + R(a) <-> T(1!1,2,3!+).R(a!1)

T(1,2,3!+) + R(a) <-> T(1,2!1,3!+).R(a!1)

Third TNF binding event

T(1!+,2!+,3) + R(a) <-> T(1!+,2!+,3!1).R(a!1)

T(1!+,2,3!+) + R(a) <-> T(1!+,2!1,3!+).R(a!1)

T(1,2!+,3!+) + R(a) <-> T(1!1,2!+,3!+).R(a!1)