Molecules

R(p,a)

R p a

T(1,2,3)

T 1 2 3

Species

R(p,a)

R p a

T(1,2,3)

T 1 2 3

Observables

R(p,a)

R p a
Molecules DimerReceptor R(p!0,a).R(p!0,a), R(a!0,p).R(a!0,p)Molecules AggregatedReceptor R(p!0,a!0)

T(1,2,3)

T 1 2 3

T(1!+,2,3)

T 1 2 3

T(1,2!+,3)

T 1 2 3

T(1,2,3!+))

T 1 2 3

T(1!+,2!+,3)

T 1 2 3

T(1!+,2,3!+)

T 1 2 3

T(1,2!+,3!+))

T 1 2 3

T(1!+,2!+,3!+)

T 1 2 3
Molecules Aggregate2TNF T(1!+,2!+,3).R(p!+).R(p!+), T(1!+,2,3!+).R(p!+).R(p!+), T(1,2!+,3!+).R(p!+).R(p!+)Molecules Aggregate3TNF T(1!+,2!+,3!+).R(p!+).R(p!+).R(p!+)Molecules NoAggregate3TNF T(1!+,2!+,3!+).R(p).R(p).R(p)

Reaction Rules

Receptor dimerization parallel1: R(p) + R(p) <-> R(p!0).R(p!0) kp, koffReceptor dimerization antiparallel2: R(a) + R(a) <-> R(a!0).R(a!0) ka, koff########################################################TNF reactions########################################################First TNF binding event

T(1,2,3) + R(a) <-> T(1!1,2,3).R(a!1)

T 1 ⬆⬇1 2 3 R p 1 ⬆⬇a

T(1,2,3) + R(a) <-> T(1,2!1,3).R(a!1)

T 1 1 ⬆⬇2 3 R p 1 ⬆⬇a

T(1,2,3) + R(a) <-> T(1,2,3!1).R(a!1)

T 1 2 1 ⬆⬇3 R p 1 ⬆⬇a
Second TNF binding event

T(1!+,2,3) + R(a) <-> T(1!+,2!1,3).R(a!1)

T 1 1 ⬆⬇2 3 R p 1 ⬆⬇a

T(1!+,2,3) + R(a) <-> T(1!+,2,3!1).R(a!1)

T 1 2 1 ⬆⬇3 R p 1 ⬆⬇a

T(1,2!+,3) + R(a) <-> T(1!1,2!+,3).R(a!1)

T 1 ⬆⬇1 2 3 R p 1 ⬆⬇a

T(1,2!+,3) + R(a) <-> T(1,2!+,3!1).R(a!1)

T 1 2 1 ⬆⬇3 R p 1 ⬆⬇a

T(1,2,3!+) + R(a) <-> T(1!1,2,3!+).R(a!1)

T 1 ⬆⬇1 2 3 R p 1 ⬆⬇a

T(1,2,3!+) + R(a) <-> T(1,2!1,3!+).R(a!1)

T 1 1 ⬆⬇2 3 R p 1 ⬆⬇a
Third TNF binding event

T(1!+,2!+,3) + R(a) <-> T(1!+,2!+,3!1).R(a!1)

T 1 2 1 ⬆⬇3 R p 1 ⬆⬇a

T(1!+,2,3!+) + R(a) <-> T(1!+,2!1,3!+).R(a!1)

T 1 1 ⬆⬇2 3 R p 1 ⬆⬇a

T(1,2!+,3!+) + R(a) <-> T(1!1,2!+,3!+).R(a!1)

T 1 ⬆⬇1 2 3 R p 1 ⬆⬇a