Molecules

E2F(DBD,RB1,Ser332~u~p)

E2F DBD RB1 Ser332 u p

RB1(E2F,Ser807_Ser811~u~p)

RB1 E2F Ser807_Ser811 u p

PPP2R2B(ENSA_ARPP19)

PPP2R2B ENSA_ARPP19

CCNB_promoter(FOXM1)

CCNB_promoter FOXM1

CCNA(CDKN1A)

CCNA CDKN1A

CCNA_promoter(E2F)

CCNA_promoter E2F

FOXM1_promoter(E2F)

FOXM1_promoter E2F

ENSA_ARPP19(PPP2R2B,Ser62_Ser67~u~p)

ENSA_ARPP19 PPP2R2B Ser62_Ser67 u p

FZR1(APC,FBXO5,nTerm~u~p)

FZR1 APC FBXO5 nTerm u p

CCNE(CDKN1A)

CCNE CDKN1A

MASTL(Thr198~u~p)

MASTL Thr198 u p

FBXO5_promoter(E2F)

FBXO5_promoter E2F

CDC20_promoter(FOXM1)

CDC20_promoter FOXM1

FBXO5(APC,FZR1,Ser182~u~p)

FBXO5 APC FZR1 Ser182 u p

iWEE()

FOXM1(DBD,Thr600~u~p)

FOXM1 DBD Thr600 u p

WEE1(Ser123~u~p)

WEE1 Ser123 u p

CCNE_promoter(E2F)

CCNE_promoter E2F

E2F_promoter(E2F)

E2F_promoter E2F

CCND()

CCND

CDC20(APC)

CDC20 APC

CDC25(pSites~u~p)

CDC25 pSites u p

CCNB(CDKN1A,CDK1_Thr14_Tyr15~u~p)

CCNB CDKN1A CDK1_Thr14_Tyr15 u p

APC(FZR1_CDC20,FBXO5,Ser355~u~p)

APC FZR1_CDC20 FBXO5 Ser355 u p

SKP2()

SKP2

CDKN1A(CCNE_A_B,Ser130~u~p)

CDKN1A CCNE_A_B Ser130 u p

TP53(DBD,Ser15~u~p)

TP53 DBD Ser15 u p

CDKN1A_promoter(TP53)

CDKN1A_promoter TP53

Species

CCND()

CCND

CCNE(CDKN1A)

CCNE CDKN1A

E2F(DBD,RB1,Ser332~u)

E2F DBD RB1 Ser332 u

E2F(DBD,RB1,Ser332~p)

E2F DBD RB1 Ser332 p

CCNA(CDKN1A)

CCNA CDKN1A

CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

CCNB CDKN1A CDK1_Thr14_Tyr15 u

E2F(DBD,RB1!1,Ser332~u).RB1(E2F!1,Ser807_Ser811~u)

E2F DBD RB1 Ser332 u RB1 E2F Ser807_Ser811 u

E2F(DBD,RB1!1,Ser332~p).RB1(E2F!1,Ser807_Ser811~u)

E2F DBD RB1 Ser332 p RB1 E2F Ser807_Ser811 u

RB1(E2F,Ser807_Ser811~u)

RB1 E2F Ser807_Ser811 u

RB1(E2F,Ser807_Ser811~p)

RB1 E2F Ser807_Ser811 p

PPP2R2B(ENSA_ARPP19)

PPP2R2B ENSA_ARPP19

APC(FZR1_CDC20,FBXO5,Ser355~u)

APC FZR1_CDC20 FBXO5 Ser355 u

CDC20(APC)

CDC20 APC

APC(FZR1_CDC20!1,FBXO5,Ser355~p).CDC20(APC!1)

APC FZR1_CDC20 FBXO5 Ser355 p CDC20 APC

APC(FZR1_CDC20,FBXO5,Ser355~p)

APC FZR1_CDC20 FBXO5 Ser355 p

APC(FZR1_CDC20!1,FBXO5,Ser355~u).FZR1(APC!1,FBXO5,nTerm~u)

APC FZR1_CDC20 FBXO5 Ser355 u FZR1 APC FBXO5 nTerm u

FZR1(APC,FBXO5,nTerm~u)

FZR1 APC FBXO5 nTerm u

FZR1(APC,FBXO5,nTerm~p)

FZR1 APC FBXO5 nTerm p

APC(FZR1_CDC20!1,FBXO5!2,Ser355~u).FZR1(APC!1,FBXO5!3,nTerm~u).FBXO5(APC!2,FZR1!3,Ser182~u)

APC FZR1_CDC20 FBXO5 Ser355 u FZR1 APC FBXO5 nTerm u FBXO5 APC FZR1 Ser182 u

FBXO5(APC,FZR1,Ser182~u)

FBXO5 APC FZR1 Ser182 u

APC(FZR1_CDC20!1,FBXO5!2,Ser355~p).FZR1(APC!1,FBXO5!3,nTerm~u).FBXO5(APC!2,FZR1!3,Ser182~u)

APC FZR1_CDC20 FBXO5 Ser355 p FZR1 APC FBXO5 nTerm u FBXO5 APC FZR1 Ser182 u

APC(FZR1_CDC20!1,FBXO5,Ser355~p).FZR1(APC!1,FBXO5,nTerm~u)

APC FZR1_CDC20 FBXO5 Ser355 p FZR1 APC FBXO5 nTerm u

FBXO5(APC,FZR1,Ser182~p)

FBXO5 APC FZR1 Ser182 p

FOXM1(DBD,Thr600~u)

FOXM1 DBD Thr600 u

FOXM1(DBD,Thr600~p)

FOXM1 DBD Thr600 p

FOXM1(DBD!1,Thr600~p).CCNB_promoter(FOXM1!1)

FOXM1 DBD Thr600 p CCNB_promoter FOXM1

CCNB_promoter(FOXM1)

CCNB_promoter FOXM1

CDC20_promoter(FOXM1)

CDC20_promoter FOXM1

FOXM1(DBD!1,Thr600~p).CDC20_promoter(FOXM1!1)

FOXM1 DBD Thr600 p CDC20_promoter FOXM1

WEE1(Ser123~u)

WEE1 Ser123 u

CCNB(CDKN1A,CDK1_Thr14_Tyr15~p)

CCNB CDKN1A CDK1_Thr14_Tyr15 p

WEE1(Ser123~p)

WEE1 Ser123 p

CDC25(pSites~p)

CDC25 pSites p

CDC25(pSites~u)

CDC25 pSites u

MASTL(Thr198~u)

MASTL Thr198 u

MASTL(Thr198~p)

MASTL Thr198 p

ENSA_ARPP19(PPP2R2B,Ser62_Ser67~u)

ENSA_ARPP19 PPP2R2B Ser62_Ser67 u

ENSA_ARPP19(PPP2R2B,Ser62_Ser67~p)

ENSA_ARPP19 PPP2R2B Ser62_Ser67 p

ENSA_ARPP19(PPP2R2B!1,Ser62_Ser67~p).PPP2R2B(ENSA_ARPP19!1)

ENSA_ARPP19 PPP2R2B Ser62_Ser67 p PPP2R2B ENSA_ARPP19

CCNE_promoter(E2F)

CCNE_promoter E2F

CCNA_promoter(E2F)

CCNA_promoter E2F

E2F_promoter(E2F)

E2F_promoter E2F

FBXO5_promoter(E2F)

FBXO5_promoter E2F

FOXM1_promoter(E2F)

FOXM1_promoter E2F

E2F(DBD!1,RB1,Ser332~u).CCNE_promoter(E2F!1)

E2F DBD RB1 Ser332 u CCNE_promoter E2F

E2F(DBD!1,RB1,Ser332~u).CCNA_promoter(E2F!1)

E2F DBD RB1 Ser332 u CCNA_promoter E2F

E2F(DBD!1,RB1,Ser332~u).E2F_promoter(E2F!1)

E2F DBD RB1 Ser332 u E2F_promoter E2F

E2F(DBD!1,RB1,Ser332~u).FBXO5_promoter(E2F!1)

E2F DBD RB1 Ser332 u FBXO5_promoter E2F

E2F(DBD!1,RB1,Ser332~u).FOXM1_promoter(E2F!1)

E2F DBD RB1 Ser332 u FOXM1_promoter E2F

E2F(DBD!1,RB1,Ser332~p).CCNE_promoter(E2F!1)

E2F DBD RB1 Ser332 p CCNE_promoter E2F

E2F(DBD!1,RB1,Ser332~p).CCNA_promoter(E2F!1)

E2F DBD RB1 Ser332 p CCNA_promoter E2F

E2F(DBD!1,RB1,Ser332~p).E2F_promoter(E2F!1)

E2F DBD RB1 Ser332 p E2F_promoter E2F

E2F(DBD!1,RB1,Ser332~p).FBXO5_promoter(E2F!1)

E2F DBD RB1 Ser332 p FBXO5_promoter E2F

E2F(DBD!1,RB1,Ser332~p).FOXM1_promoter(E2F!1)

E2F DBD RB1 Ser332 p FOXM1_promoter E2F

@cell:iWEE() (0*1) #iWee

SKP2()

SKP2

TP53(DBD,Ser15~p)

TP53 DBD Ser15 p

CDKN1A_promoter(TP53)

CDKN1A_promoter TP53

Observables

tCCNE CCNE()

CCNE ?CDKN1A

tCCNA CCNA()

CCNA ?CDKN1A

tCCNB CCNB()

CCNB ?CDKN1A CDK1_Thr14_Tyr15 u ?p

tCDKN1A CDKN1A()

CDKN1A ?CCNE_A_B Ser130 u ?p

Reaction Rules

0 -> E2F(DBD,RB1,Ser332~u)

E2F DBD RB1 Ser332 u synthesized

FOXM1(DBD,Thr600~p) + CCNB_promoter(FOXM1) <-> FOXM1(DBD!1,Thr600~p).CCNB_promoter(FOXM1!1)

FOXM1 ⬇⬆DBD Thr600 p ⬇⬆ CCNB_promoter ⬇⬆FOXM1

E2F(DBD!1,RB1).E2F_promoter(E2F!1) -> E2F(DBD!1,RB1).E2F_promoter(E2F!1) + E2F(DBD,RB1,Ser332~u)

E2F DBD RB1 Ser332 u ?p E2F_promoter E2F E2F DBD RB1 Ser332 u synthesized

E2F(DBD!?,RB1!?,Ser332) -> 0

E2F ?DBD ?RB1 Ser332 degraded

RB1(E2F!1,Ser807_Ser811~u).E2F(DBD,RB1!1,Ser332) + CCND() -> RB1(E2F,Ser807_Ser811~p) + E2F(DBD,RB1,Ser332) + CCND()

RB1 ⬆E2F Ser807_Ser811 u p take all branches, once each, in any order⬇ ⬆ E2F DBD ⬆RB1 Ser332 CCND

RB1(E2F!1,Ser807_Ser811~u).E2F(DBD,RB1!1,Ser332) + CCNE(CDKN1A) -> RB1(E2F,Ser807_Ser811~p) + E2F(DBD,RB1,Ser332) + CCNE(CDKN1A)

RB1 ⬆E2F Ser807_Ser811 u p take all branches, once each, in any order⬇ ⬆ E2F DBD ⬆RB1 Ser332 CCNE CDKN1A

RB1(E2F!1,Ser807_Ser811~u).E2F(DBD,RB1!1,Ser332) + CCNA(CDKN1A) -> RB1(E2F,Ser807_Ser811~p) + E2F(DBD,RB1,Ser332) + CCNA(CDKN1A)

RB1 ⬆E2F Ser807_Ser811 u p take all branches, once each, in any order⬇ ⬆ E2F DBD ⬆RB1 Ser332 CCNA CDKN1A

RB1(E2F!1,Ser807_Ser811~u).E2F(DBD,RB1!1,Ser332) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> RB1(E2F,Ser807_Ser811~p) + E2F(DBD,RB1,Ser332) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

RB1 ⬆E2F Ser807_Ser811 u p take all branches, once each, in any order⬇ ⬆ E2F DBD ⬆RB1 Ser332 CCNB CDKN1A CDK1_Thr14_Tyr15 u

E2F(DBD!?,RB1!?,Ser332~u) + CCNA(CDKN1A) -> E2F(DBD!?,RB1!?,Ser332~p) + CCNA(CDKN1A)

E2F ?DBD ?RB1 Ser332 u p take all branches, once each, in any order⬇ CCNA CDKN1A

E2F(DBD!?,RB1!?,Ser332~u) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> E2F(DBD!?,RB1!?,Ser332~p) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

E2F ?DBD ?RB1 Ser332 u p take all branches, once each, in any order⬇ CCNB CDKN1A CDK1_Thr14_Tyr15 u

E2F(DBD!?,RB1!?,Ser332~p) -> E2F(DBD!?,RB1!?,Ser332~u)

E2F ?DBD ?RB1 Ser332 u p take one or more branches, once each, in any order⬆

E2F(DBD!?,RB1!?,Ser332~p) + PPP2R2B(ENSA_ARPP19) -> E2F(DBD!?,RB1!?,Ser332~u) + PPP2R2B(ENSA_ARPP19)

E2F ?DBD ?RB1 Ser332 u p take one or more branches, once each, in any order⬆ PPP2R2B ENSA_ARPP19

E2F(DBD!?,RB1!?,Ser332~p) + SKP2() -> SKP2()

E2F ?DBD ?RB1 Ser332 p degraded SKP2

RB1(E2F,Ser807_Ser811~u) + CCND() -> RB1(E2F,Ser807_Ser811~p) + CCND()

RB1 E2F Ser807_Ser811 u p take all branches, once each, in any order⬇ CCND

RB1(E2F,Ser807_Ser811~u) + CCNE(CDKN1A) -> RB1(E2F,Ser807_Ser811~p) + CCNE(CDKN1A)

RB1 E2F Ser807_Ser811 u p take all branches, once each, in any order⬇ CCNE CDKN1A

RB1(E2F,Ser807_Ser811~u) + CCNA(CDKN1A) -> RB1(E2F,Ser807_Ser811~p) + CCNA(CDKN1A)

RB1 E2F Ser807_Ser811 u p take all branches, once each, in any order⬇ CCNA CDKN1A

RB1(E2F,Ser807_Ser811~u) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> RB1(E2F,Ser807_Ser811~p) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

RB1 E2F Ser807_Ser811 u p take all branches, once each, in any order⬇ CCNB CDKN1A CDK1_Thr14_Tyr15 u

0 -> CCNE(CDKN1A)

CCNE CDKN1A synthesized

E2F(DBD!1,RB1).CCNA_promoter(E2F!1) -> E2F(DBD!1,RB1).CCNA_promoter(E2F!1) + CCNA(CDKN1A)

E2F DBD RB1 Ser332 u ?p CCNA_promoter E2F CCNA CDKN1A synthesized

CCNE() -> 0

CCNE ?CDKN1A degraded

CCNE(CDKN1A) + CCNE() -> CCNE(CDKN1A)

CCNE CDKN1A CCNE ?CDKN1A degraded

RB1(E2F,Ser807_Ser811~p) -> RB1(E2F,Ser807_Ser811~u)

RB1 E2F Ser807_Ser811 u p take one or more branches, once each, in any order⬆

APC(FZR1_CDC20!1,FBXO5,Ser355~p).CDC20(APC!1) -> APC(FZR1_CDC20,FBXO5,Ser355~u) + CDC20(APC)

APC ⬆FZR1_CDC20 FBXO5 Ser355 u p take one or more branches, once each, in any order⬆ ⬆ CDC20 ⬆APC

APC(FZR1_CDC20!1,FBXO5,Ser355~p).CDC20(APC!1) + PPP2R2B(ENSA_ARPP19) -> APC(FZR1_CDC20,FBXO5,Ser355~u) + CDC20(APC) + PPP2R2B(ENSA_ARPP19)

APC ⬆FZR1_CDC20 FBXO5 Ser355 u p take one or more branches, once each, in any order⬆ ⬆ CDC20 ⬆APC PPP2R2B ENSA_ARPP19

⚠️ Molecule order mismatch - skipping reaction: reactants: APC, CCNA products: CCNA, APC
⚠️ Molecule order mismatch - skipping reaction: reactants: APC, CCNB products: CCNB, APC

APC(Ser355~p) -> APC(Ser355~u) kDpApc_1 exclude_reactants(1,CDC20()

APC ?FZR1_CDC20 ?FBXO5 Ser355 u p take one or more branches, once each, in any order⬆

⚠️ Molecule order mismatch - skipping reaction: reactants: APC, PPP2R2B products: PPP2R2B, APC

APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u) + CCNA(CDKN1A) -> APC(FZR1_CDC20,FBXO5,Ser355) + FZR1(APC,FBXO5,nTerm~p) + CCNA(CDKN1A)

APC ⬆FZR1_CDC20 FBXO5 Ser355 ⬆ FZR1 ⬆APC FBXO5 nTerm u p take all branches, once each, in any order⬇ CCNA CDKN1A

APC(FZR1_CDC20!1,FBXO5!3,Ser355).FZR1(APC!1,FBXO5!2,nTerm~u).FBXO5(APC!3,FZR1!2,Ser182~u) + CCNE(CDKN1A) -> APC(FZR1_CDC20,FBXO5,Ser355) + FZR1(APC,FBXO5,nTerm~p) + FBXO5(APC,FZR1,Ser182~u) + CCNE(CDKN1A)

APC ⬆FZR1_CDC20 ⬆FBXO5 Ser355 ⬆ FZR1 ⬆APC ⬆FBXO5 nTerm u p take all branches, once each, in any order⬇ ⬆ FBXO5 ⬆APC ⬆FZR1 Ser182 u CCNE CDKN1A

APC(FZR1_CDC20!1,FBXO5!3,Ser355).FZR1(APC!1,FBXO5!2,nTerm~u).FBXO5(APC!3,FZR1!2,Ser182~u) + CCNA(CDKN1A) -> APC(FZR1_CDC20,FBXO5,Ser355) + FZR1(APC,FBXO5,nTerm~p) + FBXO5(APC,FZR1,Ser182~u) + CCNA(CDKN1A)

APC ⬆FZR1_CDC20 ⬆FBXO5 Ser355 ⬆ FZR1 ⬆APC ⬆FBXO5 nTerm u p take all branches, once each, in any order⬇ ⬆ FBXO5 ⬆APC ⬆FZR1 Ser182 u CCNA CDKN1A

APC(FZR1_CDC20!1,FBXO5!3,Ser355).FZR1(APC!1,FBXO5!2,nTerm~u).FBXO5(APC!3,FZR1!2,Ser182~u) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> APC(FZR1_CDC20,FBXO5,Ser355) + FZR1(APC,FBXO5,nTerm~p) + FBXO5(APC,FZR1,Ser182~u) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

APC ⬆FZR1_CDC20 ⬆FBXO5 Ser355 ⬆ FZR1 ⬆APC ⬆FBXO5 nTerm u p take all branches, once each, in any order⬇ ⬆ FBXO5 ⬆APC ⬆FZR1 Ser182 u CCNB CDKN1A CDK1_Thr14_Tyr15 u

APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u) + CCNE(CDKN1A) -> APC(FZR1_CDC20,FBXO5,Ser355) + FZR1(APC,FBXO5,nTerm~p) + CCNE(CDKN1A)

APC ⬆FZR1_CDC20 FBXO5 Ser355 ⬆ FZR1 ⬆APC FBXO5 nTerm u p take all branches, once each, in any order⬇ CCNE CDKN1A

FBXO5(APC!?,FZR1!?,Ser182) -> 0

FBXO5 ?APC ?FZR1 Ser182 degraded

FBXO5(APC!+,FZR1!+,Ser182~u) -> 0

FBXO5 APC FZR1 Ser182 u degraded

APC(FZR1_CDC20!1,FBXO5!3,Ser355).FZR1(APC!1,FBXO5!2,nTerm~u).FBXO5(APC!3,FZR1!2,Ser182) + CCNA(CDKN1A) -> APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u) + FBXO5(APC,FZR1,Ser182~p) + CCNA(CDKN1A)

APC FZR1_CDC20 ⬆FBXO5 Ser355 FZR1 APC ⬆FBXO5 nTerm u ⬆ FBXO5 ⬆APC ⬆FZR1 Ser182 CCNA CDKN1A

APC(FZR1_CDC20!1,FBXO5!3,Ser355).FZR1(APC!1,FBXO5!2,nTerm~u).FBXO5(APC!3,FZR1!2,Ser182) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u) + FBXO5(APC,FZR1,Ser182~p) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

APC FZR1_CDC20 ⬆FBXO5 Ser355 FZR1 APC ⬆FBXO5 nTerm u ⬆ FBXO5 ⬆APC ⬆FZR1 Ser182 CCNB CDKN1A CDK1_Thr14_Tyr15 u

FBXO5(APC,FZR1,Ser182~u) + CCNA(CDKN1A) -> FBXO5(APC,FZR1,Ser182~p) + CCNA(CDKN1A)

FBXO5 APC FZR1 Ser182 u p take all branches, once each, in any order⬇ CCNA CDKN1A

FBXO5(APC,FZR1,Ser182~u) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> FBXO5(APC,FZR1,Ser182~p) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

FBXO5 APC FZR1 Ser182 u p take all branches, once each, in any order⬇ CCNB CDKN1A CDK1_Thr14_Tyr15 u

FBXO5(APC,FZR1,Ser182~p) -> FBXO5(APC,FZR1,Ser182~u)

FBXO5 APC FZR1 Ser182 u p take one or more branches, once each, in any order⬆

FBXO5(APC,FZR1,Ser182~p) -> 0

FBXO5 APC FZR1 Ser182 p degraded

0 -> FOXM1(DBD,Thr600~u)

FOXM1 DBD Thr600 u synthesized

E2F(DBD!1,RB1).FBXO5_promoter(E2F!1) -> E2F(DBD!1,RB1).FBXO5_promoter(E2F!1) + FBXO5(APC,FZR1,Ser182~u)

E2F DBD RB1 Ser332 u ?p FBXO5_promoter E2F FBXO5 APC FZR1 Ser182 u synthesized

FZR1(APC,FBXO5,nTerm~u) + CCNE(CDKN1A) -> FZR1(APC,FBXO5,nTerm~p) + CCNE(CDKN1A)

FZR1 APC FBXO5 nTerm u p take all branches, once each, in any order⬇ CCNE CDKN1A

FZR1(APC,FBXO5,nTerm~u) + CCNA(CDKN1A) -> FZR1(APC,FBXO5,nTerm~p) + CCNA(CDKN1A)

FZR1 APC FBXO5 nTerm u p take all branches, once each, in any order⬇ CCNA CDKN1A

FZR1(APC,FBXO5,nTerm~u) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> FZR1(APC,FBXO5,nTerm~p) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

FZR1 APC FBXO5 nTerm u p take all branches, once each, in any order⬇ CCNB CDKN1A CDK1_Thr14_Tyr15 u

FZR1(APC,FBXO5,nTerm~p) -> FZR1(APC,FBXO5,nTerm~u)

FZR1 APC FBXO5 nTerm u p take one or more branches, once each, in any order⬆

0 -> CCNA(CDKN1A)

CCNA CDKN1A synthesized

CCNA() -> 0

CCNA ?CDKN1A degraded

CCNE() + CCNA(CDKN1A) -> CCNA(CDKN1A)

CCNE ?CDKN1A degraded CCNA CDKN1A

CCNA() + APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u) -> APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u)

CCNA ?CDKN1A degraded APC FZR1_CDC20 FBXO5 Ser355 FZR1 APC FBXO5 nTerm u

CCNA() + APC(FZR1_CDC20!1,FBXO5,Ser355~p).CDC20(APC!1) -> APC(FZR1_CDC20!1,FBXO5,Ser355~p).CDC20(APC!1)

CCNA ?CDKN1A degraded APC FZR1_CDC20 FBXO5 Ser355 p CDC20 APC

E2F(DBD!1,RB1).FOXM1_promoter(E2F!1) -> E2F(DBD!1,RB1).FOXM1_promoter(E2F!1) + FOXM1(DBD,Thr600~u)

E2F DBD RB1 Ser332 u ?p FOXM1_promoter E2F FOXM1 DBD Thr600 u synthesized

FOXM1(DBD!?,Thr600) -> 0

FOXM1 ?DBD Thr600 degraded

FOXM1(DBD!?,Thr600) + APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u) -> APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u)

FOXM1 ?DBD Thr600 degraded APC FZR1_CDC20 FBXO5 Ser355 FZR1 APC FBXO5 nTerm u

⚠️ Molecule order mismatch - skipping reaction: reactants: FOXM1, CCNE products: CCNE, FOXM1
⚠️ Molecule order mismatch - skipping reaction: reactants: FOXM1, CCNA products: CCNA, FOXM1
⚠️ Molecule order mismatch - skipping reaction: reactants: FOXM1, CCNB products: CCNB, FOXM1

FOXM1(DBD,Thr600~p) -> FOXM1(DBD,Thr600~u)

FOXM1 DBD Thr600 u p take one or more branches, once each, in any order⬆

FOXM1(DBD!1,Thr600~p).CDC20_promoter(FOXM1!1) -> FOXM1(DBD,Thr600~u) + CDC20_promoter(FOXM1)

FOXM1 ⬆DBD Thr600 u p take one or more branches, once each, in any order⬆ ⬆ CDC20_promoter ⬆FOXM1

FOXM1(DBD!1,Thr600~p).CCNB_promoter(FOXM1!1) -> FOXM1(DBD,Thr600~u) + CCNB_promoter(FOXM1)

FOXM1 ⬆DBD Thr600 u p take one or more branches, once each, in any order⬆ ⬆ CCNB_promoter ⬆FOXM1

0 -> CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

CCNB CDKN1A CDK1_Thr14_Tyr15 u synthesized

FOXM1(DBD!1,Thr600~p).CCNB_promoter(FOXM1!1) -> FOXM1(DBD!1,Thr600~p).CCNB_promoter(FOXM1!1) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

FOXM1 DBD Thr600 p CCNB_promoter FOXM1 CCNB CDKN1A CDK1_Thr14_Tyr15 u synthesized

CCNB(CDK1_Thr14_Tyr15) -> 0

CCNB ?CDKN1A CDK1_Thr14_Tyr15 degraded

CCNB(CDK1_Thr14_Tyr15) + APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u) -> APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u)

CCNB ?CDKN1A CDK1_Thr14_Tyr15 degraded APC FZR1_CDC20 FBXO5 Ser355 FZR1 APC FBXO5 nTerm u

CCNB(CDK1_Thr14_Tyr15) + APC(FZR1_CDC20!1,FBXO5,Ser355~p).CDC20(APC!1) -> APC(FZR1_CDC20!1,FBXO5,Ser355~p).CDC20(APC!1)

CCNB ?CDKN1A CDK1_Thr14_Tyr15 degraded APC FZR1_CDC20 FBXO5 Ser355 p CDC20 APC

CDC20(APC!?) -> 0

CDC20 ?APC degraded

CDC20(APC!?) + APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u) -> APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u)

CDC20 ?APC degraded APC FZR1_CDC20 FBXO5 Ser355 FZR1 APC FBXO5 nTerm u

0 -> CDC20(APC)

CDC20 APC synthesized

FOXM1(DBD!1,Thr600~p).CDC20_promoter(FOXM1!1) -> FOXM1(DBD!1,Thr600~p).CDC20_promoter(FOXM1!1) + CDC20(APC)

FOXM1 DBD Thr600 p CDC20_promoter FOXM1 CDC20 APC synthesized

FOXM1(DBD,Thr600~p) + CDC20_promoter(FOXM1) <-> FOXM1(DBD!1,Thr600~p).CDC20_promoter(FOXM1!1)

FOXM1 ⬇⬆DBD Thr600 p ⬇⬆ CDC20_promoter ⬇⬆FOXM1

⚠️ Molecule order mismatch - skipping reaction: reactants: CCNB, WEE1 products: WEE1, CCNB
⚠️ Molecule order mismatch - skipping reaction: reactants: CCNB, WEE1 products: WEE1, CCNB
⚠️ Molecule order mismatch - skipping reaction: reactants: CCNB, CDC25 products: CDC25, CCNB
⚠️ Molecule order mismatch - skipping reaction: reactants: CCNB, CDC25 products: CDC25, CCNB
⚠️ Molecule order mismatch - skipping reaction: reactants: CDC25, CCNB products: CCNB, CDC25
⚠️ Molecule order mismatch - skipping reaction: reactants: CDC25, CCNA products: CCNA, CDC25
⚠️ Molecule order mismatch - skipping reaction: reactants: CDC25, PPP2R2B products: PPP2R2B, CDC25
⚠️ Molecule order mismatch - skipping reaction: reactants: WEE1, PPP2R2B products: PPP2R2B, WEE1
⚠️ Molecule order mismatch - skipping reaction: reactants: WEE1, CCNA products: CCNA, WEE1
⚠️ Molecule order mismatch - skipping reaction: reactants: WEE1, CCNB products: CCNB, WEE1

MASTL(Thr198~u) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> MASTL(Thr198~p) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

MASTL Thr198 u p take all branches, once each, in any order⬇ CCNB CDKN1A CDK1_Thr14_Tyr15 u

MASTL(Thr198~p) -> MASTL(Thr198~u)

MASTL Thr198 u p take one or more branches, once each, in any order⬆

⚠️ Molecule order mismatch - skipping reaction: reactants: MASTL, PPP2R2B products: PPP2R2B, MASTL

ENSA_ARPP19(PPP2R2B,Ser62_Ser67~u) + MASTL(Thr198~p) -> ENSA_ARPP19(PPP2R2B,Ser62_Ser67~p) + MASTL(Thr198~p)

ENSA_ARPP19 PPP2R2B Ser62_Ser67 u p take all branches, once each, in any order⬇ MASTL Thr198 p

⚠️ Molecule order mismatch - skipping reaction: reactants: ENSA_ARPP19, PPP2R2B products: PPP2R2B, ENSA_ARPP19

0 -> FBXO5(APC,FZR1,Ser182~u)

FBXO5 APC FZR1 Ser182 u synthesized

E2F(DBD!1,RB1).CCNE_promoter(E2F!1) -> E2F(DBD!1,RB1).CCNE_promoter(E2F!1) + CCNE(CDKN1A)

E2F DBD RB1 Ser332 u ?p CCNE_promoter E2F CCNE CDKN1A synthesized

APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> APC(FZR1_CDC20,FBXO5,Ser355) + FZR1(APC,FBXO5,nTerm~p) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

APC ⬆FZR1_CDC20 FBXO5 Ser355 ⬆ FZR1 ⬆APC FBXO5 nTerm u p take all branches, once each, in any order⬇ CCNB CDKN1A CDK1_Thr14_Tyr15 u

E2F(DBD,RB1,Ser332) + RB1(E2F,Ser807_Ser811~u) <-> E2F(DBD,RB1!1,Ser332).RB1(E2F!1,Ser807_Ser811~u)

E2F DBD ⬇⬆RB1 Ser332 ⬇⬆ RB1 ⬇⬆E2F Ser807_Ser811 u

APC(FZR1_CDC20,FBXO5,Ser355) + FZR1(APC,FBXO5,nTerm~u) <-> APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u)

APC ⬇⬆FZR1_CDC20 FBXO5 Ser355 ⬇⬆ FZR1 ⬇⬆APC FBXO5 nTerm u

APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u) + FBXO5(APC,FZR1,Ser182~u) <-> APC(FZR1_CDC20!1,FBXO5!2,Ser355).FZR1(APC!1,FBXO5!3,nTerm~u).FBXO5(APC!2,FZR1!3,Ser182~u)

APC FZR1_CDC20 ⬇⬆FBXO5 Ser355 FZR1 APC ⬇⬆FBXO5 nTerm u ⬇⬆ FBXO5 ⬇⬆APC ⬇⬆FZR1 Ser182 u

APC(FZR1_CDC20,FBXO5,Ser355~p) + CDC20(APC) <-> APC(FZR1_CDC20!1,FBXO5,Ser355~p).CDC20(APC!1)

APC ⬇⬆FZR1_CDC20 FBXO5 Ser355 p ⬇⬆ CDC20 ⬇⬆APC

ENSA_ARPP19(PPP2R2B,Ser62_Ser67~p) + PPP2R2B(ENSA_ARPP19) <-> ENSA_ARPP19(PPP2R2B!1,Ser62_Ser67~p).PPP2R2B(ENSA_ARPP19!1)

ENSA_ARPP19 ⬇⬆PPP2R2B Ser62_Ser67 p ⬇⬆ PPP2R2B ⬇⬆ENSA_ARPP19

E2F(DBD,RB1) + CCNE_promoter(E2F) <-> E2F(DBD!1,RB1).CCNE_promoter(E2F!1)

E2F ⬇⬆DBD RB1 Ser332 u ?p ⬇⬆ CCNE_promoter ⬇⬆E2F

E2F(DBD,RB1) + CCNA_promoter(E2F) <-> E2F(DBD!1,RB1).CCNA_promoter(E2F!1)

E2F ⬇⬆DBD RB1 Ser332 u ?p ⬇⬆ CCNA_promoter ⬇⬆E2F

E2F(DBD,RB1) + E2F_promoter(E2F) <-> E2F(DBD!1,RB1).E2F_promoter(E2F!1)

E2F ⬇⬆DBD RB1 Ser332 u ?p ⬇⬆ E2F_promoter ⬇⬆E2F

E2F(DBD,RB1) + FBXO5_promoter(E2F) <-> E2F(DBD!1,RB1).FBXO5_promoter(E2F!1)

E2F ⬇⬆DBD RB1 Ser332 u ?p ⬇⬆ FBXO5_promoter ⬇⬆E2F

E2F(DBD,RB1) + FOXM1_promoter(E2F) <-> E2F(DBD!1,RB1).FOXM1_promoter(E2F!1)

E2F ⬇⬆DBD RB1 Ser332 u ?p ⬇⬆ FOXM1_promoter ⬇⬆E2F

0 -> SKP2()

SKP2 synthesized

SKP2() -> 0

SKP2 degraded

SKP2() + APC(FZR1_CDC20!1,FBXO5).FZR1(APC!1,FBXO5) -> APC(FZR1_CDC20!1,FBXO5).FZR1(APC!1,FBXO5)

SKP2 degraded APC FZR1_CDC20 FBXO5 Ser355 u ?p FZR1 APC FBXO5 nTerm u ?p

TP53(DBD,Ser15~p) + CDKN1A_promoter(TP53) <-> TP53(DBD!1,Ser15~p).CDKN1A_promoter(TP53!1)

TP53 ⬇⬆DBD Ser15 p ⬇⬆ CDKN1A_promoter ⬇⬆TP53

0 -> CDKN1A(CCNE_A_B,Ser130~u)

CDKN1A CCNE_A_B Ser130 u synthesized

TP53(DBD!1,Ser15~p).CDKN1A_promoter(TP53!1) -> TP53(DBD!1,Ser15~p).CDKN1A_promoter(TP53!1) + CDKN1A(CCNE_A_B,Ser130~u)

TP53 DBD Ser15 p CDKN1A_promoter TP53 CDKN1A CCNE_A_B Ser130 u synthesized

CDKN1A() -> 0

CDKN1A ?CCNE_A_B Ser130 u ?p degraded

CDKN1A(Ser130~p) + SKP2() -> SKP2()

CDKN1A ?CCNE_A_B Ser130 p degraded SKP2

CDKN1A(Ser130~u) + SKP2() -> SKP2()

CDKN1A ?CCNE_A_B Ser130 u degraded SKP2

CDKN1A(CCNE_A_B,Ser130~u) + CCNA(CDKN1A) <-> CDKN1A(CCNE_A_B!1,Ser130~u).CCNA(CDKN1A!1)

CDKN1A ⬇⬆CCNE_A_B Ser130 u ⬇⬆ CCNA ⬇⬆CDKN1A

CDKN1A(CCNE_A_B,Ser130~u) + CCNE(CDKN1A) <-> CDKN1A(CCNE_A_B!1,Ser130~u).CCNE(CDKN1A!1)

CDKN1A ⬇⬆CCNE_A_B Ser130 u ⬇⬆ CCNE ⬇⬆CDKN1A

CDKN1A(CCNE_A_B,Ser130~u) + CCNB(CDKN1A) <-> CDKN1A(CCNE_A_B!1,Ser130~u).CCNB(CDKN1A!1)

CDKN1A ⬇⬆CCNE_A_B Ser130 u ⬇⬆ CCNB ⬇⬆CDKN1A CDK1_Thr14_Tyr15 u ?p

CDKN1A(CCNE_A_B,Ser130~u) + CCNE(CDKN1A) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNE(CDKN1A)

CDKN1A CCNE_A_B Ser130 u p take all branches, once each, in any order⬇ CCNE CDKN1A

CDKN1A(CCNE_A_B!1,Ser130~u).CCNA(CDKN1A!1) + CCNE(CDKN1A) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNA(CDKN1A) + CCNE(CDKN1A)

CDKN1A ⬆CCNE_A_B Ser130 u p take all branches, once each, in any order⬇ ⬆ CCNA ⬆CDKN1A CCNE CDKN1A

CDKN1A(CCNE_A_B!1,Ser130~u).CCNE(CDKN1A!1) + CCNE(CDKN1A) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNE(CDKN1A) + CCNE(CDKN1A)

CDKN1A ⬆CCNE_A_B Ser130 u p take all branches, once each, in any order⬇ ⬆ CCNE ⬆CDKN1A CCNE CDKN1A

CDKN1A(CCNE_A_B!1,Ser130~u).CCNB(CDKN1A!1) + CCNE(CDKN1A) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNB(CDKN1A) + CCNE(CDKN1A)

CDKN1A ⬆CCNE_A_B Ser130 u p take all branches, once each, in any order⬇ ⬆ CCNB ⬆CDKN1A CDK1_Thr14_Tyr15 u ?p CCNE CDKN1A

CDKN1A(CCNE_A_B,Ser130~u) + CCNA(CDKN1A) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNA(CDKN1A)

CDKN1A CCNE_A_B Ser130 u p take all branches, once each, in any order⬇ CCNA CDKN1A

CDKN1A(CCNE_A_B!1,Ser130~u).CCNA(CDKN1A!1) + CCNA(CDKN1A) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNA(CDKN1A) + CCNA(CDKN1A)

CDKN1A ⬆CCNE_A_B Ser130 u p take all branches, once each, in any order⬇ ⬆ CCNA ⬆CDKN1A CCNA CDKN1A

CDKN1A(CCNE_A_B!1,Ser130~u).CCNE(CDKN1A!1) + CCNA(CDKN1A) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNE(CDKN1A) + CCNA(CDKN1A)

CDKN1A ⬆CCNE_A_B Ser130 u p take all branches, once each, in any order⬇ ⬆ CCNE ⬆CDKN1A CCNA CDKN1A

CDKN1A(CCNE_A_B!1,Ser130~u).CCNB(CDKN1A!1) + CCNA(CDKN1A) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNB(CDKN1A) + CCNA(CDKN1A)

CDKN1A ⬆CCNE_A_B Ser130 u p take all branches, once each, in any order⬇ ⬆ CCNB ⬆CDKN1A CDK1_Thr14_Tyr15 u ?p CCNA CDKN1A

CDKN1A(CCNE_A_B,Ser130~u) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

CDKN1A CCNE_A_B Ser130 u p take all branches, once each, in any order⬇ CCNB CDKN1A CDK1_Thr14_Tyr15 u

CDKN1A(CCNE_A_B!1,Ser130~u).CCNA(CDKN1A!1) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNA(CDKN1A) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

CDKN1A ⬆CCNE_A_B Ser130 u p take all branches, once each, in any order⬇ ⬆ CCNA ⬆CDKN1A CCNB CDKN1A CDK1_Thr14_Tyr15 u

CDKN1A(CCNE_A_B!1,Ser130~u).CCNE(CDKN1A!1) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNE(CDKN1A) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

CDKN1A ⬆CCNE_A_B Ser130 u p take all branches, once each, in any order⬇ ⬆ CCNE ⬆CDKN1A CCNB CDKN1A CDK1_Thr14_Tyr15 u

CDKN1A(CCNE_A_B!1,Ser130~u).CCNB(CDKN1A!1) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNB(CDKN1A) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

CDKN1A ⬆CCNE_A_B Ser130 u p take all branches, once each, in any order⬇ ⬆ CCNB ⬆CDKN1A CDK1_Thr14_Tyr15 u ?p CCNB CDKN1A CDK1_Thr14_Tyr15 u

CDKN1A(Ser130~p) -> CDKN1A(Ser130~u)

CDKN1A ?CCNE_A_B Ser130 u p take one or more branches, once each, in any order⬆