Molecules

E2F(DBD,RB1,Ser332~u~p)

E2F DBD RB1 Ser332 u p

RB1(E2F,Ser807_Ser811~u~p)

RB1 E2F Ser807_Ser811 u p

PPP2R2B(ENSA_ARPP19)

PPP2R2B ENSA_ARPP19

CCNB_promoter(FOXM1)

CCNB_promoter FOXM1

CCNA(CDKN1A)

CCNA CDKN1A

CCNA_promoter(E2F)

CCNA_promoter E2F

FOXM1_promoter(E2F)

FOXM1_promoter E2F

ENSA_ARPP19(PPP2R2B,Ser62_Ser67~u~p)

ENSA_ARPP19 PPP2R2B Ser62_Ser67 u p

FZR1(APC,FBXO5,nTerm~u~p)

FZR1 APC FBXO5 nTerm u p

CCNE(CDKN1A)

CCNE CDKN1A

MASTL(Thr198~u~p)

MASTL Thr198 u p

FBXO5_promoter(E2F)

FBXO5_promoter E2F

CDC20_promoter(FOXM1)

CDC20_promoter FOXM1

FBXO5(APC,FZR1,Ser182~u~p)

FBXO5 APC FZR1 Ser182 u p
iWEE()

FOXM1(DBD,Thr600~u~p)

FOXM1 DBD Thr600 u p

WEE1(Ser123~u~p)

WEE1 Ser123 u p

CCNE_promoter(E2F)

CCNE_promoter E2F

E2F_promoter(E2F)

E2F_promoter E2F

CCND()

CCND

CDC20(APC)

CDC20 APC

CDC25(pSites~u~p)

CDC25 pSites u p

CCNB(CDKN1A,CDK1_Thr14_Tyr15~u~p)

CCNB CDKN1A CDK1_Thr14_Tyr15 u p

APC(FZR1_CDC20,FBXO5,Ser355~u~p)

APC FZR1_CDC20 FBXO5 Ser355 u p

SKP2()

SKP2

CDKN1A(CCNE_A_B,Ser130~u~p)

CDKN1A CCNE_A_B Ser130 u p

TP53(DBD,Ser15~u~p)

TP53 DBD Ser15 u p

CDKN1A_promoter(TP53)

CDKN1A_promoter TP53

Species

CCND()

CCND

CCNE(CDKN1A)

CCNE CDKN1A

E2F(DBD,RB1,Ser332~u)

E2F DBD RB1 Ser332 u

E2F(DBD,RB1,Ser332~p)

E2F DBD RB1 Ser332 p

CCNA(CDKN1A)

CCNA CDKN1A

CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

CCNB CDKN1A CDK1_Thr14_Tyr15 u

E2F(DBD,RB1!1,Ser332~u).RB1(E2F!1,Ser807_Ser811~u)

E2F DBD 1RB1 Ser332 u RB1 1E2F Ser807_Ser811 u

E2F(DBD,RB1!1,Ser332~p).RB1(E2F!1,Ser807_Ser811~u)

E2F DBD 1RB1 Ser332 p RB1 1E2F Ser807_Ser811 u

RB1(E2F,Ser807_Ser811~u)

RB1 E2F Ser807_Ser811 u

RB1(E2F,Ser807_Ser811~p)

RB1 E2F Ser807_Ser811 p

PPP2R2B(ENSA_ARPP19)

PPP2R2B ENSA_ARPP19

APC(FZR1_CDC20,FBXO5,Ser355~u)

APC FZR1_CDC20 FBXO5 Ser355 u

CDC20(APC)

CDC20 APC

APC(FZR1_CDC20!1,FBXO5,Ser355~p).CDC20(APC!1)

APC 1FZR1_CDC20 FBXO5 Ser355 p CDC20 1APC

APC(FZR1_CDC20,FBXO5,Ser355~p)

APC FZR1_CDC20 FBXO5 Ser355 p

APC(FZR1_CDC20!1,FBXO5,Ser355~u).FZR1(APC!1,FBXO5,nTerm~u)

APC 1FZR1_CDC20 FBXO5 Ser355 u FZR1 1APC FBXO5 nTerm u

FZR1(APC,FBXO5,nTerm~u)

FZR1 APC FBXO5 nTerm u

FZR1(APC,FBXO5,nTerm~p)

FZR1 APC FBXO5 nTerm p

APC(FZR1_CDC20!1,FBXO5!2,Ser355~u).FZR1(APC!1,FBXO5!3,nTerm~u).FBXO5(APC!2,FZR1!3,Ser182~u)

APC 1FZR1_CDC20 2FBXO5 Ser355 u FZR1 1APC 3FBXO5 nTerm u FBXO5 2APC 3FZR1 Ser182 u

FBXO5(APC,FZR1,Ser182~u)

FBXO5 APC FZR1 Ser182 u

APC(FZR1_CDC20!1,FBXO5!2,Ser355~p).FZR1(APC!1,FBXO5!3,nTerm~u).FBXO5(APC!2,FZR1!3,Ser182~u)

APC 1FZR1_CDC20 2FBXO5 Ser355 p FZR1 1APC 3FBXO5 nTerm u FBXO5 2APC 3FZR1 Ser182 u

APC(FZR1_CDC20!1,FBXO5,Ser355~p).FZR1(APC!1,FBXO5,nTerm~u)

APC 1FZR1_CDC20 FBXO5 Ser355 p FZR1 1APC FBXO5 nTerm u

FBXO5(APC,FZR1,Ser182~p)

FBXO5 APC FZR1 Ser182 p

FOXM1(DBD,Thr600~u)

FOXM1 DBD Thr600 u

FOXM1(DBD,Thr600~p)

FOXM1 DBD Thr600 p

FOXM1(DBD!1,Thr600~p).CCNB_promoter(FOXM1!1)

FOXM1 1DBD Thr600 p CCNB_promoter 1FOXM1

CCNB_promoter(FOXM1)

CCNB_promoter FOXM1

CDC20_promoter(FOXM1)

CDC20_promoter FOXM1

FOXM1(DBD!1,Thr600~p).CDC20_promoter(FOXM1!1)

FOXM1 1DBD Thr600 p CDC20_promoter 1FOXM1

WEE1(Ser123~u)

WEE1 Ser123 u

CCNB(CDKN1A,CDK1_Thr14_Tyr15~p)

CCNB CDKN1A CDK1_Thr14_Tyr15 p

WEE1(Ser123~p)

WEE1 Ser123 p

CDC25(pSites~p)

CDC25 pSites p

CDC25(pSites~u)

CDC25 pSites u

MASTL(Thr198~u)

MASTL Thr198 u

MASTL(Thr198~p)

MASTL Thr198 p

ENSA_ARPP19(PPP2R2B,Ser62_Ser67~u)

ENSA_ARPP19 PPP2R2B Ser62_Ser67 u

ENSA_ARPP19(PPP2R2B,Ser62_Ser67~p)

ENSA_ARPP19 PPP2R2B Ser62_Ser67 p

ENSA_ARPP19(PPP2R2B!1,Ser62_Ser67~p).PPP2R2B(ENSA_ARPP19!1)

ENSA_ARPP19 1PPP2R2B Ser62_Ser67 p PPP2R2B 1ENSA_ARPP19

CCNE_promoter(E2F)

CCNE_promoter E2F

CCNA_promoter(E2F)

CCNA_promoter E2F

E2F_promoter(E2F)

E2F_promoter E2F

FBXO5_promoter(E2F)

FBXO5_promoter E2F

FOXM1_promoter(E2F)

FOXM1_promoter E2F

E2F(DBD!1,RB1,Ser332~u).CCNE_promoter(E2F!1)

E2F 1DBD RB1 Ser332 u CCNE_promoter 1E2F

E2F(DBD!1,RB1,Ser332~u).CCNA_promoter(E2F!1)

E2F 1DBD RB1 Ser332 u CCNA_promoter 1E2F

E2F(DBD!1,RB1,Ser332~u).E2F_promoter(E2F!1)

E2F 1DBD RB1 Ser332 u E2F_promoter 1E2F

E2F(DBD!1,RB1,Ser332~u).FBXO5_promoter(E2F!1)

E2F 1DBD RB1 Ser332 u FBXO5_promoter 1E2F

E2F(DBD!1,RB1,Ser332~u).FOXM1_promoter(E2F!1)

E2F 1DBD RB1 Ser332 u FOXM1_promoter 1E2F

E2F(DBD!1,RB1,Ser332~p).CCNE_promoter(E2F!1)

E2F 1DBD RB1 Ser332 p CCNE_promoter 1E2F

E2F(DBD!1,RB1,Ser332~p).CCNA_promoter(E2F!1)

E2F 1DBD RB1 Ser332 p CCNA_promoter 1E2F

E2F(DBD!1,RB1,Ser332~p).E2F_promoter(E2F!1)

E2F 1DBD RB1 Ser332 p E2F_promoter 1E2F

E2F(DBD!1,RB1,Ser332~p).FBXO5_promoter(E2F!1)

E2F 1DBD RB1 Ser332 p FBXO5_promoter 1E2F

E2F(DBD!1,RB1,Ser332~p).FOXM1_promoter(E2F!1)

E2F 1DBD RB1 Ser332 p FOXM1_promoter 1E2F
@cell:iWEE() (0*1) #iWee

SKP2()

SKP2

TP53(DBD,Ser15~p)

TP53 DBD Ser15 p

CDKN1A_promoter(TP53)

CDKN1A_promoter TP53

Observables

CCNE()

CCNE CDKN1A

CCNA()

CCNA CDKN1A

CCNB()

CCNB CDKN1A CDK1_Thr14_Tyr15 u p

CDKN1A()

CDKN1A CCNE_A_B Ser130 u p

Reaction Rules

FOXM1(DBD,Thr600~p) + CCNB_promoter(FOXM1) <-> FOXM1(DBD!1,Thr600~p).CCNB_promoter(FOXM1!1)

FOXM1 1 ⬆⬇DBD Thr600 p CCNB_promoter 1 ⬆⬇FOXM1

RB1(E2F!1,Ser807_Ser811~u).E2F(DBD,RB1!1,Ser332) + CCND() -> RB1(E2F,Ser807_Ser811~p) + E2F(DBD,RB1,Ser332) + CCND()

RB1 1 ⬆E2F Ser807_Ser811 u p take all branches, once each, in any order⬇⬇ E2F DBD 1 ⬆RB1 Ser332 CCND

RB1(E2F!1,Ser807_Ser811~u).E2F(DBD,RB1!1,Ser332) + CCNE(CDKN1A) -> RB1(E2F,Ser807_Ser811~p) + E2F(DBD,RB1,Ser332) + CCNE(CDKN1A)

RB1 1 ⬆E2F Ser807_Ser811 u p take all branches, once each, in any order⬇⬇ E2F DBD 1 ⬆RB1 Ser332 CCNE CDKN1A

RB1(E2F!1,Ser807_Ser811~u).E2F(DBD,RB1!1,Ser332) + CCNA(CDKN1A) -> RB1(E2F,Ser807_Ser811~p) + E2F(DBD,RB1,Ser332) + CCNA(CDKN1A)

RB1 1 ⬆E2F Ser807_Ser811 u p take all branches, once each, in any order⬇⬇ E2F DBD 1 ⬆RB1 Ser332 CCNA CDKN1A

RB1(E2F!1,Ser807_Ser811~u).E2F(DBD,RB1!1,Ser332) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> RB1(E2F,Ser807_Ser811~p) + E2F(DBD,RB1,Ser332) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

RB1 1 ⬆E2F Ser807_Ser811 u p take all branches, once each, in any order⬇⬇ E2F DBD 1 ⬆RB1 Ser332 CCNB CDKN1A CDK1_Thr14_Tyr15 u

E2F(DBD!?,RB1!?,Ser332~u) + CCNA(CDKN1A) -> E2F(DBD!?,RB1!?,Ser332~p) + CCNA(CDKN1A)

E2F DBD RB1 Ser332 u p take all branches, once each, in any order⬇⬇ CCNA CDKN1A

E2F(DBD!?,RB1!?,Ser332~u) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> E2F(DBD!?,RB1!?,Ser332~p) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

E2F DBD RB1 Ser332 u p take all branches, once each, in any order⬇⬇ CCNB CDKN1A CDK1_Thr14_Tyr15 u

E2F(DBD!?,RB1!?,Ser332~p) -> E2F(DBD!?,RB1!?,Ser332~u)

E2F DBD RB1 Ser332 u p take one or more branches, once each, in any order⬆⬆

E2F(DBD!?,RB1!?,Ser332~p) + PPP2R2B(ENSA_ARPP19) -> E2F(DBD!?,RB1!?,Ser332~u) + PPP2R2B(ENSA_ARPP19)

E2F DBD RB1 Ser332 u p take one or more branches, once each, in any order⬆⬆ PPP2R2B ENSA_ARPP19

RB1(E2F,Ser807_Ser811~u) + CCND() -> RB1(E2F,Ser807_Ser811~p) + CCND()

RB1 E2F Ser807_Ser811 u p take all branches, once each, in any order⬇⬇ CCND

RB1(E2F,Ser807_Ser811~u) + CCNE(CDKN1A) -> RB1(E2F,Ser807_Ser811~p) + CCNE(CDKN1A)

RB1 E2F Ser807_Ser811 u p take all branches, once each, in any order⬇⬇ CCNE CDKN1A

RB1(E2F,Ser807_Ser811~u) + CCNA(CDKN1A) -> RB1(E2F,Ser807_Ser811~p) + CCNA(CDKN1A)

RB1 E2F Ser807_Ser811 u p take all branches, once each, in any order⬇⬇ CCNA CDKN1A

RB1(E2F,Ser807_Ser811~u) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> RB1(E2F,Ser807_Ser811~p) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

RB1 E2F Ser807_Ser811 u p take all branches, once each, in any order⬇⬇ CCNB CDKN1A CDK1_Thr14_Tyr15 u

RB1(E2F,Ser807_Ser811~p) -> RB1(E2F,Ser807_Ser811~u)

RB1 E2F Ser807_Ser811 u p take one or more branches, once each, in any order⬆⬆

APC(FZR1_CDC20!1,FBXO5,Ser355~p).CDC20(APC!1) -> APC(FZR1_CDC20,FBXO5,Ser355~u) + CDC20(APC)

APC 1 ⬆FZR1_CDC20 FBXO5 Ser355 u p take one or more branches, once each, in any order⬆⬆ CDC20 1 ⬆APC

APC(FZR1_CDC20!1,FBXO5,Ser355~p).CDC20(APC!1) + PPP2R2B(ENSA_ARPP19) -> APC(FZR1_CDC20,FBXO5,Ser355~u) + CDC20(APC) + PPP2R2B(ENSA_ARPP19)

APC 1 ⬆FZR1_CDC20 FBXO5 Ser355 u p take one or more branches, once each, in any order⬆⬆ CDC20 1 ⬆APC PPP2R2B ENSA_ARPP19

APC(Ser355~p) -> APC(Ser355~u) kDpApc_1 exclude_reactants(1,CDC20())

APC FZR1_CDC20 FBXO5 Ser355 u p take one or more branches, once each, in any order⬆⬆

APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u) + CCNA(CDKN1A) -> APC(FZR1_CDC20,FBXO5,Ser355) + FZR1(APC,FBXO5,nTerm~p) + CCNA(CDKN1A)

APC 1 ⬆FZR1_CDC20 FBXO5 Ser355 FZR1 1 ⬆APC FBXO5 nTerm u p take all branches, once each, in any order⬇⬇ CCNA CDKN1A

APC(FZR1_CDC20!1,FBXO5!3,Ser355).FZR1(APC!1,FBXO5!2,nTerm~u).FBXO5(APC!3,FZR1!2,Ser182~u) + CCNE(CDKN1A) -> APC(FZR1_CDC20,FBXO5,Ser355) + FZR1(APC,FBXO5,nTerm~p) + FBXO5(APC,FZR1,Ser182~u) + CCNE(CDKN1A)

APC 1 ⬆FZR1_CDC20 3 ⬆FBXO5 Ser355 FZR1 1 ⬆APC 2 ⬆FBXO5 nTerm u p take all branches, once each, in any order⬇⬇ FBXO5 3 ⬆APC 2 ⬆FZR1 Ser182 u CCNE CDKN1A

APC(FZR1_CDC20!1,FBXO5!3,Ser355).FZR1(APC!1,FBXO5!2,nTerm~u).FBXO5(APC!3,FZR1!2,Ser182~u) + CCNA(CDKN1A) -> APC(FZR1_CDC20,FBXO5,Ser355) + FZR1(APC,FBXO5,nTerm~p) + FBXO5(APC,FZR1,Ser182~u) + CCNA(CDKN1A)

APC 1 ⬆FZR1_CDC20 3 ⬆FBXO5 Ser355 FZR1 1 ⬆APC 2 ⬆FBXO5 nTerm u p take all branches, once each, in any order⬇⬇ FBXO5 3 ⬆APC 2 ⬆FZR1 Ser182 u CCNA CDKN1A

APC(FZR1_CDC20!1,FBXO5!3,Ser355).FZR1(APC!1,FBXO5!2,nTerm~u).FBXO5(APC!3,FZR1!2,Ser182~u) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> APC(FZR1_CDC20,FBXO5,Ser355) + FZR1(APC,FBXO5,nTerm~p) + FBXO5(APC,FZR1,Ser182~u) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

APC 1 ⬆FZR1_CDC20 3 ⬆FBXO5 Ser355 FZR1 1 ⬆APC 2 ⬆FBXO5 nTerm u p take all branches, once each, in any order⬇⬇ FBXO5 3 ⬆APC 2 ⬆FZR1 Ser182 u CCNB CDKN1A CDK1_Thr14_Tyr15 u

APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u) + CCNE(CDKN1A) -> APC(FZR1_CDC20,FBXO5,Ser355) + FZR1(APC,FBXO5,nTerm~p) + CCNE(CDKN1A)

APC 1 ⬆FZR1_CDC20 FBXO5 Ser355 FZR1 1 ⬆APC FBXO5 nTerm u p take all branches, once each, in any order⬇⬇ CCNE CDKN1A

APC(FZR1_CDC20!1,FBXO5!3,Ser355).FZR1(APC!1,FBXO5!2,nTerm~u).FBXO5(APC!3,FZR1!2,Ser182) + CCNA(CDKN1A) -> APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u) + FBXO5(APC,FZR1,Ser182~p) + CCNA(CDKN1A)

APC 1FZR1_CDC20 3 ⬆FBXO5 Ser355 FZR1 1APC 2 ⬆FBXO5 nTerm u FBXO5 3 ⬆APC 2 ⬆FZR1 Ser182 CCNA CDKN1A

APC(FZR1_CDC20!1,FBXO5!3,Ser355).FZR1(APC!1,FBXO5!2,nTerm~u).FBXO5(APC!3,FZR1!2,Ser182) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u) + FBXO5(APC,FZR1,Ser182~p) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

APC 1FZR1_CDC20 3 ⬆FBXO5 Ser355 FZR1 1APC 2 ⬆FBXO5 nTerm u FBXO5 3 ⬆APC 2 ⬆FZR1 Ser182 CCNB CDKN1A CDK1_Thr14_Tyr15 u

FBXO5(APC,FZR1,Ser182~u) + CCNA(CDKN1A) -> FBXO5(APC,FZR1,Ser182~p) + CCNA(CDKN1A)

FBXO5 APC FZR1 Ser182 u p take all branches, once each, in any order⬇⬇ CCNA CDKN1A

FBXO5(APC,FZR1,Ser182~u) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> FBXO5(APC,FZR1,Ser182~p) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

FBXO5 APC FZR1 Ser182 u p take all branches, once each, in any order⬇⬇ CCNB CDKN1A CDK1_Thr14_Tyr15 u

FBXO5(APC,FZR1,Ser182~p) -> FBXO5(APC,FZR1,Ser182~u)

FBXO5 APC FZR1 Ser182 u p take one or more branches, once each, in any order⬆⬆

FZR1(APC,FBXO5,nTerm~u) + CCNE(CDKN1A) -> FZR1(APC,FBXO5,nTerm~p) + CCNE(CDKN1A)

FZR1 APC FBXO5 nTerm u p take all branches, once each, in any order⬇⬇ CCNE CDKN1A

FZR1(APC,FBXO5,nTerm~u) + CCNA(CDKN1A) -> FZR1(APC,FBXO5,nTerm~p) + CCNA(CDKN1A)

FZR1 APC FBXO5 nTerm u p take all branches, once each, in any order⬇⬇ CCNA CDKN1A

FZR1(APC,FBXO5,nTerm~u) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> FZR1(APC,FBXO5,nTerm~p) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

FZR1 APC FBXO5 nTerm u p take all branches, once each, in any order⬇⬇ CCNB CDKN1A CDK1_Thr14_Tyr15 u

FZR1(APC,FBXO5,nTerm~p) -> FZR1(APC,FBXO5,nTerm~u)

FZR1 APC FBXO5 nTerm u p take one or more branches, once each, in any order⬆⬆

FOXM1(DBD,Thr600~p) -> FOXM1(DBD,Thr600~u)

FOXM1 DBD Thr600 u p take one or more branches, once each, in any order⬆⬆

FOXM1(DBD!1,Thr600~p).CDC20_promoter(FOXM1!1) -> FOXM1(DBD,Thr600~u) + CDC20_promoter(FOXM1)

FOXM1 1 ⬆DBD Thr600 u p take one or more branches, once each, in any order⬆⬆ CDC20_promoter 1 ⬆FOXM1

FOXM1(DBD!1,Thr600~p).CCNB_promoter(FOXM1!1) -> FOXM1(DBD,Thr600~u) + CCNB_promoter(FOXM1)

FOXM1 1 ⬆DBD Thr600 u p take one or more branches, once each, in any order⬆⬆ CCNB_promoter 1 ⬆FOXM1

FOXM1(DBD,Thr600~p) + CDC20_promoter(FOXM1) <-> FOXM1(DBD!1,Thr600~p).CDC20_promoter(FOXM1!1)

FOXM1 1 ⬆⬇DBD Thr600 p CDC20_promoter 1 ⬆⬇FOXM1

MASTL(Thr198~u) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> MASTL(Thr198~p) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

MASTL Thr198 u p take all branches, once each, in any order⬇⬇ CCNB CDKN1A CDK1_Thr14_Tyr15 u

MASTL(Thr198~p) -> MASTL(Thr198~u)

MASTL Thr198 u p take one or more branches, once each, in any order⬆⬆

ENSA_ARPP19(PPP2R2B,Ser62_Ser67~u) + MASTL(Thr198~p) -> ENSA_ARPP19(PPP2R2B,Ser62_Ser67~p) + MASTL(Thr198~p)

ENSA_ARPP19 PPP2R2B Ser62_Ser67 u p take all branches, once each, in any order⬇⬇ MASTL Thr198 p

APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> APC(FZR1_CDC20,FBXO5,Ser355) + FZR1(APC,FBXO5,nTerm~p) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

APC 1 ⬆FZR1_CDC20 FBXO5 Ser355 FZR1 1 ⬆APC FBXO5 nTerm u p take all branches, once each, in any order⬇⬇ CCNB CDKN1A CDK1_Thr14_Tyr15 u

E2F(DBD,RB1,Ser332) + RB1(E2F,Ser807_Ser811~u) <-> E2F(DBD,RB1!1,Ser332).RB1(E2F!1,Ser807_Ser811~u)

E2F DBD 1 ⬆⬇RB1 Ser332 RB1 1 ⬆⬇E2F Ser807_Ser811 u

APC(FZR1_CDC20,FBXO5,Ser355) + FZR1(APC,FBXO5,nTerm~u) <-> APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u)

APC 1 ⬆⬇FZR1_CDC20 FBXO5 Ser355 FZR1 1 ⬆⬇APC FBXO5 nTerm u

APC(FZR1_CDC20!1,FBXO5,Ser355).FZR1(APC!1,FBXO5,nTerm~u) + FBXO5(APC,FZR1,Ser182~u) <-> APC(FZR1_CDC20!1,FBXO5!2,Ser355).FZR1(APC!1,FBXO5!3,nTerm~u).FBXO5(APC!2,FZR1!3,Ser182~u)

APC 1FZR1_CDC20 2 ⬆⬇FBXO5 Ser355 FZR1 1APC 3 ⬆⬇FBXO5 nTerm u FBXO5 2 ⬆⬇APC 3 ⬆⬇FZR1 Ser182 u

APC(FZR1_CDC20,FBXO5,Ser355~p) + CDC20(APC) <-> APC(FZR1_CDC20!1,FBXO5,Ser355~p).CDC20(APC!1)

APC 1 ⬆⬇FZR1_CDC20 FBXO5 Ser355 p CDC20 1 ⬆⬇APC

ENSA_ARPP19(PPP2R2B,Ser62_Ser67~p) + PPP2R2B(ENSA_ARPP19) <-> ENSA_ARPP19(PPP2R2B!1,Ser62_Ser67~p).PPP2R2B(ENSA_ARPP19!1)

ENSA_ARPP19 1 ⬆⬇PPP2R2B Ser62_Ser67 p PPP2R2B 1 ⬆⬇ENSA_ARPP19

E2F(DBD,RB1) + CCNE_promoter(E2F) <-> E2F(DBD!1,RB1).CCNE_promoter(E2F!1)

E2F 1 ⬆⬇DBD RB1 Ser332 u p CCNE_promoter 1 ⬆⬇E2F

E2F(DBD,RB1) + CCNA_promoter(E2F) <-> E2F(DBD!1,RB1).CCNA_promoter(E2F!1)

E2F 1 ⬆⬇DBD RB1 Ser332 u p CCNA_promoter 1 ⬆⬇E2F

E2F(DBD,RB1) + E2F_promoter(E2F) <-> E2F(DBD!1,RB1).E2F_promoter(E2F!1)

E2F 1 ⬆⬇DBD RB1 Ser332 u p E2F_promoter 1 ⬆⬇E2F

E2F(DBD,RB1) + FBXO5_promoter(E2F) <-> E2F(DBD!1,RB1).FBXO5_promoter(E2F!1)

E2F 1 ⬆⬇DBD RB1 Ser332 u p FBXO5_promoter 1 ⬆⬇E2F

E2F(DBD,RB1) + FOXM1_promoter(E2F) <-> E2F(DBD!1,RB1).FOXM1_promoter(E2F!1)

E2F 1 ⬆⬇DBD RB1 Ser332 u p FOXM1_promoter 1 ⬆⬇E2F

TP53(DBD,Ser15~p) + CDKN1A_promoter(TP53) <-> TP53(DBD!1,Ser15~p).CDKN1A_promoter(TP53!1)

TP53 1 ⬆⬇DBD Ser15 p CDKN1A_promoter 1 ⬆⬇TP53

CDKN1A(CCNE_A_B,Ser130~u) + CCNA(CDKN1A) <-> CDKN1A(CCNE_A_B!1,Ser130~u).CCNA(CDKN1A!1)

CDKN1A 1 ⬆⬇CCNE_A_B Ser130 u CCNA 1 ⬆⬇CDKN1A

CDKN1A(CCNE_A_B,Ser130~u) + CCNE(CDKN1A) <-> CDKN1A(CCNE_A_B!1,Ser130~u).CCNE(CDKN1A!1)

CDKN1A 1 ⬆⬇CCNE_A_B Ser130 u CCNE 1 ⬆⬇CDKN1A

CDKN1A(CCNE_A_B,Ser130~u) + CCNB(CDKN1A) <-> CDKN1A(CCNE_A_B!1,Ser130~u).CCNB(CDKN1A!1)

CDKN1A 1 ⬆⬇CCNE_A_B Ser130 u CCNB 1 ⬆⬇CDKN1A CDK1_Thr14_Tyr15 u p

CDKN1A(CCNE_A_B,Ser130~u) + CCNE(CDKN1A) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNE(CDKN1A)

CDKN1A CCNE_A_B Ser130 u p take all branches, once each, in any order⬇⬇ CCNE CDKN1A

CDKN1A(CCNE_A_B!1,Ser130~u).CCNA(CDKN1A!1) + CCNE(CDKN1A) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNA(CDKN1A) + CCNE(CDKN1A)

CDKN1A 1 ⬆CCNE_A_B Ser130 u p take all branches, once each, in any order⬇⬇ CCNA 1 ⬆CDKN1A CCNE CDKN1A

CDKN1A(CCNE_A_B!1,Ser130~u).CCNE(CDKN1A!1) + CCNE(CDKN1A) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNE(CDKN1A) + CCNE(CDKN1A)

CDKN1A 1 ⬆CCNE_A_B Ser130 u p take all branches, once each, in any order⬇⬇ CCNE 1 ⬆CDKN1A CCNE CDKN1A

CDKN1A(CCNE_A_B!1,Ser130~u).CCNB(CDKN1A!1) + CCNE(CDKN1A) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNB(CDKN1A) + CCNE(CDKN1A)

CDKN1A 1 ⬆CCNE_A_B Ser130 u p take all branches, once each, in any order⬇⬇ CCNB 1 ⬆CDKN1A CDK1_Thr14_Tyr15 u p CCNE CDKN1A

CDKN1A(CCNE_A_B,Ser130~u) + CCNA(CDKN1A) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNA(CDKN1A)

CDKN1A CCNE_A_B Ser130 u p take all branches, once each, in any order⬇⬇ CCNA CDKN1A

CDKN1A(CCNE_A_B!1,Ser130~u).CCNA(CDKN1A!1) + CCNA(CDKN1A) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNA(CDKN1A) + CCNA(CDKN1A)

CDKN1A 1 ⬆CCNE_A_B Ser130 u p take all branches, once each, in any order⬇⬇ CCNA 1 ⬆CDKN1A CCNA CDKN1A

CDKN1A(CCNE_A_B!1,Ser130~u).CCNE(CDKN1A!1) + CCNA(CDKN1A) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNE(CDKN1A) + CCNA(CDKN1A)

CDKN1A 1 ⬆CCNE_A_B Ser130 u p take all branches, once each, in any order⬇⬇ CCNE 1 ⬆CDKN1A CCNA CDKN1A

CDKN1A(CCNE_A_B!1,Ser130~u).CCNB(CDKN1A!1) + CCNA(CDKN1A) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNB(CDKN1A) + CCNA(CDKN1A)

CDKN1A 1 ⬆CCNE_A_B Ser130 u p take all branches, once each, in any order⬇⬇ CCNB 1 ⬆CDKN1A CDK1_Thr14_Tyr15 u p CCNA CDKN1A

CDKN1A(CCNE_A_B,Ser130~u) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

CDKN1A CCNE_A_B Ser130 u p take all branches, once each, in any order⬇⬇ CCNB CDKN1A CDK1_Thr14_Tyr15 u

CDKN1A(CCNE_A_B!1,Ser130~u).CCNA(CDKN1A!1) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNA(CDKN1A) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

CDKN1A 1 ⬆CCNE_A_B Ser130 u p take all branches, once each, in any order⬇⬇ CCNA 1 ⬆CDKN1A CCNB CDKN1A CDK1_Thr14_Tyr15 u

CDKN1A(CCNE_A_B!1,Ser130~u).CCNE(CDKN1A!1) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNE(CDKN1A) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

CDKN1A 1 ⬆CCNE_A_B Ser130 u p take all branches, once each, in any order⬇⬇ CCNE 1 ⬆CDKN1A CCNB CDKN1A CDK1_Thr14_Tyr15 u

CDKN1A(CCNE_A_B!1,Ser130~u).CCNB(CDKN1A!1) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u) -> CDKN1A(CCNE_A_B,Ser130~p) + CCNB(CDKN1A) + CCNB(CDKN1A,CDK1_Thr14_Tyr15~u)

CDKN1A 1 ⬆CCNE_A_B Ser130 u p take all branches, once each, in any order⬇⬇ CCNB 1 ⬆CDKN1A CDK1_Thr14_Tyr15 u p CCNB CDKN1A CDK1_Thr14_Tyr15 u

CDKN1A(Ser130~p) -> CDKN1A(Ser130~u)

CDKN1A CCNE_A_B Ser130 u p take one or more branches, once each, in any order⬆⬆