Molecules

PolyIC(Rigi,loc~ext~cyt)

PolyIC Rigi loc ext cyt

RIGI(Polyic,Mavs)

RIGI Polyic Mavs

MAVS(Rigi)

MAVS Rigi

PKR(st~i~a)

PKR st i a

OAS3(st~i~a)

OAS3 st i a

RNaseL(st~i~a)

RNaseL st i a

eIF2a(st~0~p)

eIF2a st 0 p

RIGI_mRNA()

RIGI_mRNA

PKR_mRNA()

PKR_mRNA

OAS3_mRNA()

OAS3_mRNA

RNaseL_mRNA()

RNaseL_mRNA

TNFa()

TNFa

TAK1(st~i~a)

TAK1 st i a

IKK(st~n~a~i~ii)

IKK st n a i ii

IkBa(Nfkb,loc~nuc~cyt,Ser32_Ser36~0~pp)

IkBa Nfkb loc nuc cyt Ser32_Ser36 0 pp

NFkB(Ikba,loc~nuc~cyt)

NFkB Ikba loc nuc cyt

A20()

A20

IkBa_mRNA()

IkBa_mRNA

A20_mRNA()

A20_mRNA

TBK1(Ser172~0~p)

TBK1 Ser172 0 p

IRF3(Ser396~0~p)

IRF3 Ser396 0 p

IFNAR(Ifnb)

IFNAR Ifnb

IFNb(Ifnar,loc~ext~cyt)

IFNb Ifnar loc ext cyt

IFNAR_mRNA()

IFNAR_mRNA

IFNb_mRNA()

IFNb_mRNA

STAT1(Stat2,Tyr701~0~p)

STAT1 Stat2 Tyr701 0 p

STAT2(Stat1,Tyr690~0~p)

STAT2 Stat1 Tyr690 0 p

STAT1_mRNA()

STAT1_mRNA

STAT2_mRNA()

STAT2_mRNA

Species

PolyIC(Rigi,loc~ext)

PolyIC Rigi loc ext

RIGI(Mavs,Polyic)

RIGI Mavs Polyic

MAVS(Rigi)

MAVS Rigi

PKR(st~i)

PKR st i

OAS3(st~i)

OAS3 st i

RNaseL(st~i)

RNaseL st i

eIF2a(st~0)

eIF2a st 0

RIGI_mRNA()

RIGI_mRNA

PKR_mRNA()

PKR_mRNA

OAS3_mRNA()

OAS3_mRNA

RNaseL_mRNA()

RNaseL_mRNA

TNFa()

TNFa

NFkB(Ikba!0,loc~cyt).IkBa(Nfkb!0,loc~cyt,Ser32_Ser36~0)

NFkB Ikba loc cyt IkBa Nfkb loc cyt Ser32_Ser36 0

TAK1(st~i)

TAK1 st i

IKK(st~n)

IKK st n

A20()

A20

IkBa_mRNA()

IkBa_mRNA

A20_mRNA()

A20_mRNA

TBK1(Ser172~0)

TBK1 Ser172 0

IRF3(Ser396~0)

IRF3 Ser396 0

IFNAR(Ifnb)

IFNAR Ifnb

IFNb(Ifnar,loc~cyt)

IFNb Ifnar loc cyt

IFNb(Ifnar,loc~ext)

IFNb Ifnar loc ext

IFNAR_mRNA()

IFNAR_mRNA

IFNb_mRNA()

IFNb_mRNA

STAT1(Stat2,Tyr701~0)

STAT1 Stat2 Tyr701 0

STAT2(Stat1,Tyr690~0)

STAT2 Stat1 Tyr690 0

STAT1(Stat2!1,Tyr701~p).STAT2(Stat1!1,Tyr690~p)

STAT1 Stat2 Tyr701 p STAT2 Stat1 Tyr690 p

STAT1_mRNA()

STAT1_mRNA

STAT2_mRNA()

STAT2_mRNA

Observables

RIG_I_total RIGI(Mavs!?,Polyic!?)

RIGI ?Polyic ?Mavs

PKR_total PKR()

PKR st i ?a

OAS3_total OAS3()

OAS3 st i ?a

RNaseL_total RNaseL()

RNaseL st i ?a

RNaseL_a RNaseL(st~a)

RNaseL st a

eIF2a_total eIF2a()

eIF2a st 0 ?p

eIF2a_p eIF2a(st~p)

eIF2a st p

RIGI_mRNA RIGI_mRNA()

RIGI_mRNA

PKR_mRNA PKR_mRNA()

PKR_mRNA

OAS3_mRNA OAS3_mRNA()

OAS3_mRNA

RNaseL_mRNA RNaseL_mRNA()

RNaseL_mRNA

TAK1_a TAK1(st~a)

TAK1 st a

NFkB_nuc_free NFkB(loc~nuc,Ikba)

NFkB Ikba loc nuc

NFkB_nuc_total NFkB(loc~nuc)

NFkB ?Ikba loc nuc

NFkB_total NFkB()

NFkB ?Ikba loc nuc ?cyt

IkBa_total IkBa(Nfkb,loc~cyt,Ser32_Ser36~pp)

IkBa Nfkb loc cyt Ser32_Ser36 pp

IkBa_total IkBa(Nfkb,loc~nuc,Ser32_Ser36~0)

IkBa Nfkb loc nuc Ser32_Ser36 0

IkBa_total IkBa(Nfkb,loc~nuc,Ser32_Ser36~pp)

IkBa Nfkb loc nuc Ser32_Ser36 pp

IkBa_total IkBa(Nfkb,loc~cyt,Ser32_Ser36~0)

IkBa Nfkb loc cyt Ser32_Ser36 0

IkBa_total IkBa(Nfkb!+,loc~cyt,Ser32_Ser36~pp)

IkBa Nfkb loc cyt Ser32_Ser36 pp

IkBa_total IkBa(Nfkb!+,loc~nuc,Ser32_Ser36~0)

IkBa Nfkb loc nuc Ser32_Ser36 0

IkBa_total IkBa(Nfkb!+,loc~nuc,Ser32_Ser36~pp)

IkBa Nfkb loc nuc Ser32_Ser36 pp

IkBa_total IkBa(Nfkb!+,loc~cyt,Ser32_Ser36~0)

IkBa Nfkb loc cyt Ser32_Ser36 0

IkBa_nuc_total IkBa(Nfkb,loc~nuc,Ser32_Ser36~0)

IkBa Nfkb loc nuc Ser32_Ser36 0

IkBa_nuc_total IkBa(Nfkb,loc~nuc,Ser32_Ser36~pp)

IkBa Nfkb loc nuc Ser32_Ser36 pp

IkBa_nuc_total IkBa(Nfkb!+,loc~nuc,Ser32_Ser36~0)

IkBa Nfkb loc nuc Ser32_Ser36 0

IkBa_nuc_total IkBa(Nfkb!+,loc~nuc,Ser32_Ser36~pp)

IkBa Nfkb loc nuc Ser32_Ser36 pp

IkBa_cyt_total IkBa(Nfkb,loc~cyt,Ser32_Ser36~pp)

IkBa Nfkb loc cyt Ser32_Ser36 pp

IkBa_cyt_total IkBa(Nfkb,loc~cyt,Ser32_Ser36~0)

IkBa Nfkb loc cyt Ser32_Ser36 0

IkBa_cyt_total IkBa(Nfkb!+,loc~cyt,Ser32_Ser36~pp)

IkBa Nfkb loc cyt Ser32_Ser36 pp

IkBa_cyt_total IkBa(Nfkb!+,loc~cyt,Ser32_Ser36~0)

IkBa Nfkb loc cyt Ser32_Ser36 0

IkBa_cyt_free IkBa(Nfkb,loc~cyt,Ser32_Ser36~pp)

IkBa Nfkb loc cyt Ser32_Ser36 pp

IkBa_cyt_free IkBa(Nfkb,loc~cyt,Ser32_Ser36~0)

IkBa Nfkb loc cyt Ser32_Ser36 0

IkBa_p_cyt IkBa(Nfkb,loc~cyt,Ser32_Ser36~pp)

IkBa Nfkb loc cyt Ser32_Ser36 pp

IkBa_p_cyt IkBa(Nfkb!+,loc~cyt,Ser32_Ser36~pp)

IkBa Nfkb loc cyt Ser32_Ser36 pp

IkBa_nuc_free IkBa(Nfkb,loc~nuc,Ser32_Ser36~0)

IkBa Nfkb loc nuc Ser32_Ser36 0

A20 A20()

A20

IKK_a IKK(st~a)

IKK st a

IkBa_mRNA IkBa_mRNA()

IkBa_mRNA

A20_mRNA A20_mRNA()

A20_mRNA

IRF3_total IRF3()

IRF3 Ser396 0 ?p

IRF3_p IRF3(Ser396~p)

IRF3 Ser396 p

IFNAR_total IFNAR()

IFNAR ?Ifnb

IFNAR_a IFNAR(Ifnb!+)

IFNAR Ifnb

IFNb_ext IFNb(loc~ext)

IFNb ?Ifnar loc ext

IFNb_cyt IFNb(loc~cyt)

IFNb ?Ifnar loc cyt

IFNAR_mRNA IFNAR_mRNA()

IFNAR_mRNA

IFNb_mRNA IFNb_mRNA()

IFNb_mRNA

STAT1_total STAT1()

STAT1 ?Stat2 Tyr701 0 ?p

STAT2_total STAT2()

STAT2 ?Stat1 Tyr690 0 ?p

STAT1_p STAT1(Tyr701~p)

STAT1 ?Stat2 Tyr701 p

STAT2_p STAT2(Tyr690~p)

STAT2 ?Stat1 Tyr690 p

STAT1_u STAT1(Stat2,Tyr701~0)

STAT1 Stat2 Tyr701 0

STAT2_u STAT2(Stat1,Tyr690~0)

STAT2 Stat1 Tyr690 0

STAT12_dimer STAT1(Stat2!1,Tyr701~p).STAT2(Stat1!1,Tyr690~p)

STAT1 Stat2 Tyr701 p STAT2 Stat1 Tyr690 p

STAT1_mRNA STAT1_mRNA()

STAT1_mRNA

STAT2_mRNA STAT2_mRNA()

STAT2_mRNA

Reaction Rules

PolyIC(Rigi,loc~ext) -> PolyIC(Rigi,loc~cyt)

PolyIC Rigi loc ext cyt take all branches, once each, in any order⬇

RIGI(Mavs,Polyic) + PolyIC(Rigi,loc~cyt) -> RIGI(Mavs,Polyic!1).PolyIC(Rigi!1,loc~cyt)

RIGI ⬇Polyic Mavs ⬇ PolyIC ⬇Rigi loc cyt

RIGI(Mavs,Polyic!1).PolyIC(Rigi!1,loc~cyt) -> PolyIC(Rigi,loc~cyt)

RIGI ⬆Polyic Mavs degraded ⬆ PolyIC ⬆Rigi loc cyt

RIGI(Mavs,Polyic!+) + MAVS(Rigi) -> RIGI(Mavs!1,Polyic!+).MAVS(Rigi!1)

RIGI Polyic ⬇Mavs ⬇ MAVS ⬇Rigi

PolyIC(Rigi!1,loc~cyt).RIGI(Mavs!2,Polyic!1).MAVS(Rigi!2) -> PolyIC(Rigi,loc~cyt) + MAVS(Rigi)

PolyIC ⬆Rigi loc cyt ⬆ RIGI ⬆Polyic ⬆Mavs degraded ⬆ MAVS ⬆Rigi

PolyIC(loc~cyt) + PKR(st~i) -> PolyIC(loc~cyt) + PKR(st~a)

PolyIC ?Rigi loc cyt PKR st i a take all branches, once each, in any order⬇

PKR(st~a) -> PKR(st~i)

PKR st i a take one or more branches, once each, in any order⬆

PolyIC(loc~cyt) + OAS3(st~i) -> PolyIC(loc~cyt) + OAS3(st~a)

PolyIC ?Rigi loc cyt OAS3 st i a take all branches, once each, in any order⬇

OAS3(st~a) -> OAS3(st~i)

OAS3 st i a take one or more branches, once each, in any order⬆

PKR(st~a) + eIF2a(st~0) -> PKR(st~a) + eIF2a(st~p)

PKR st a eIF2a st 0 p take all branches, once each, in any order⬇

eIF2a(st~0) -> eIF2a(st~p)

eIF2a st 0 p take all branches, once each, in any order⬇

eIF2a(st~p) -> eIF2a(st~0)

eIF2a st 0 p take one or more branches, once each, in any order⬆

OAS3(st~a) + RNaseL(st~i) -> OAS3(st~a) + RNaseL(st~a)

OAS3 st a RNaseL st i a take all branches, once each, in any order⬇

RNaseL(st~a) -> RNaseL(st~i)

RNaseL st i a take one or more branches, once each, in any order⬆

0 -> RIGI_mRNA()

RIGI_mRNA synthesized

0 -> PKR_mRNA()

PKR_mRNA synthesized

0 -> OAS3_mRNA()

OAS3_mRNA synthesized

0 -> RNaseL_mRNA()

RNaseL_mRNA synthesized

RIGI_mRNA() -> 0

RIGI_mRNA degraded

PKR_mRNA() -> 0

PKR_mRNA degraded

OAS3_mRNA() -> 0

OAS3_mRNA degraded

RNaseL_mRNA() -> 0

RNaseL_mRNA degraded

RIGI_mRNA() -> RIGI_mRNA() + RIGI(Mavs,Polyic)

RIGI_mRNA RIGI Polyic Mavs synthesized

PKR_mRNA() -> PKR_mRNA() + PKR(st~i)

PKR_mRNA PKR st i synthesized

OAS3_mRNA() -> OAS3_mRNA() + OAS3(st~i)

OAS3_mRNA OAS3 st i synthesized

RNaseL_mRNA() -> RNaseL_mRNA() + RNaseL(st~i)

RNaseL_mRNA RNaseL st i synthesized

RIGI(Mavs,Polyic) -> 0

RIGI Polyic Mavs degraded

PKR() -> 0

PKR st i ?a degraded

OAS3() -> 0

OAS3 st i ?a degraded

RNaseL() -> 0

RNaseL st i ?a degraded

RIGI(Mavs!1,Polyic!+).MAVS(Rigi!1) + TAK1(st~i) -> RIGI(Mavs!1,Polyic!+).MAVS(Rigi!1) + TAK1(st~a)

RIGI Polyic Mavs MAVS Rigi TAK1 st i a take all branches, once each, in any order⬇

TNFa() + TAK1(st~i) -> TNFa() + TAK1(st~a)

TNFa TAK1 st i a take all branches, once each, in any order⬇

TAK1(st~a) -> TAK1(st~i)

TAK1 st i a take one or more branches, once each, in any order⬆

IKK(st~n) -> IKK(st~a)

IKK st n a take all branches, once each, in any order⬇

IKK(st~a) -> IKK(st~i)

IKK st a i take all branches, once each, in any order⬇

IKK(st~i) -> IKK(st~ii)

IKK st i ii take all branches, once each, in any order⬇

IKK(st~ii) -> IKK(st~n)

IKK st n ii take one or more branches, once each, in any order⬆

IkBa(Nfkb,loc~cyt,Ser32_Ser36~0) + NFkB(Ikba,loc~cyt) -> IkBa(Nfkb!1,loc~cyt,Ser32_Ser36~0).NFkB(Ikba!1,loc~cyt)

IkBa ⬇Nfkb loc cyt Ser32_Ser36 0 ⬇ NFkB ⬇Ikba loc cyt

IkBa(Nfkb,loc~nuc,Ser32_Ser36~0) + NFkB(Ikba,loc~nuc) -> IkBa(Nfkb!1,loc~nuc,Ser32_Ser36~0).NFkB(Ikba!1,loc~nuc)

IkBa ⬇Nfkb loc nuc Ser32_Ser36 0 ⬇ NFkB ⬇Ikba loc nuc

IKK(st~a) + IkBa(Nfkb,loc~cyt,Ser32_Ser36~0) -> IKK(st~a) + IkBa(Nfkb,loc~cyt,Ser32_Ser36~pp)

IKK st a IkBa Nfkb loc cyt Ser32_Ser36 0 pp take all branches, once each, in any order⬇

IKK(st~a) + IkBa(Nfkb!+,loc~cyt,Ser32_Ser36~0) -> IKK(st~a) + IkBa(Nfkb!+,loc~cyt,Ser32_Ser36~pp)

IKK st a IkBa Nfkb loc cyt Ser32_Ser36 0 pp take all branches, once each, in any order⬇

IkBa(Nfkb,loc~cyt,Ser32_Ser36~pp) -> 0

IkBa Nfkb loc cyt Ser32_Ser36 pp degraded

IkBa(Nfkb!1,loc~cyt,Ser32_Ser36~pp).NFkB(Ikba!1,loc~cyt) -> NFkB(Ikba,loc~cyt)

IkBa ⬆Nfkb loc cyt Ser32_Ser36 pp degraded ⬆ NFkB ⬆Ikba loc cyt

IkBa(Nfkb,loc~cyt,Ser32_Ser36~0) -> 0

IkBa Nfkb loc cyt Ser32_Ser36 0 degraded

IkBa(Nfkb!1,loc~cyt,Ser32_Ser36~0).NFkB(Ikba!1,loc~cyt) -> NFkB(Ikba,loc~cyt)

IkBa ⬆Nfkb loc cyt Ser32_Ser36 0 degraded ⬆ NFkB ⬆Ikba loc cyt

NFkB(Ikba,loc~cyt) -> NFkB(Ikba,loc~nuc)

NFkB Ikba loc nuc cyt take one or more branches, once each, in any order⬆

IkBa(Nfkb!1,loc~nuc,Ser32_Ser36~0).NFkB(Ikba!1,loc~nuc) -> IkBa(Nfkb!1,loc~cyt,Ser32_Ser36~0).NFkB(Ikba!1,loc~cyt)

IkBa Nfkb loc nuc cyt take all branches, once each, in any order⬇ Ser32_Ser36 0 NFkB Ikba loc nuc cyt take all branches, once each, in any order⬇

IkBa(Nfkb,loc~cyt,Ser32_Ser36~0) <-> IkBa(Nfkb,loc~nuc,Ser32_Ser36~0)

IkBa Nfkb loc nuc cyt take one or more branches, once each, in any order⬆⬇ Ser32_Ser36 0

0 -> IkBa_mRNA()

IkBa_mRNA synthesized

IkBa_mRNA() -> 0

IkBa_mRNA degraded

0 -> A20_mRNA()

A20_mRNA synthesized

A20_mRNA() -> 0

A20_mRNA degraded

IkBa_mRNA() -> IkBa_mRNA() + IkBa(Nfkb,loc~cyt,Ser32_Ser36~0)

IkBa_mRNA IkBa Nfkb loc cyt Ser32_Ser36 0 synthesized

A20_mRNA() -> A20_mRNA() + A20()

A20_mRNA A20 synthesized

A20() -> 0

A20 degraded

RIGI(Mavs!+,Polyic!+) + TBK1(Ser172~0) -> RIGI(Mavs!+,Polyic!+) + TBK1(Ser172~p)

RIGI Polyic Mavs TBK1 Ser172 0 p take all branches, once each, in any order⬇

TBK1(Ser172~p) -> TBK1(Ser172~0)

TBK1 Ser172 0 p take one or more branches, once each, in any order⬆

A20() + TBK1(Ser172~p) -> A20() + TBK1(Ser172~0)

A20 TBK1 Ser172 0 p take one or more branches, once each, in any order⬆

TBK1(Ser172~p) + IRF3(Ser396~0) -> TBK1(Ser172~p) + IRF3(Ser396~p)

TBK1 Ser172 p IRF3 Ser396 0 p take all branches, once each, in any order⬇

IRF3(Ser396~p) -> IRF3(Ser396~0)

IRF3 Ser396 0 p take one or more branches, once each, in any order⬆

IFNAR(Ifnb) + IFNb(Ifnar,loc~cyt) -> IFNAR(Ifnb!1).IFNb(Ifnar!1,loc~ext)

IFNAR ⬇Ifnb ⬇ IFNb ⬇Ifnar loc ext cyt take one or more branches, once each, in any order⬆

IFNAR(Ifnb) + IFNb(Ifnar,loc~ext) -> IFNAR(Ifnb!1).IFNb(Ifnar!1,loc~ext)

IFNAR ⬇Ifnb ⬇ IFNb ⬇Ifnar loc ext

0 <-> IFNAR_mRNA()

IFNAR_mRNA synthesized

IFNAR_mRNA() -> IFNAR_mRNA() + IFNAR(Ifnb)

IFNAR_mRNA IFNAR Ifnb synthesized

IFNAR(Ifnb) -> 0

IFNAR Ifnb degraded

IFNAR(Ifnb!+) -> 0

IFNAR Ifnb degraded

0 -> IFNb_mRNA()

IFNb_mRNA synthesized

IFNb_mRNA() -> 0

IFNb_mRNA degraded

IFNb_mRNA() -> IFNb_mRNA() + IFNb(Ifnar,loc~cyt)

IFNb_mRNA IFNb Ifnar loc cyt synthesized

IFNb(Ifnar,loc~cyt) -> 0

IFNb Ifnar loc cyt degraded

STAT1(Stat2,Tyr701~0) <-> STAT1(Stat2,Tyr701~p)

STAT1 Stat2 Tyr701 0 p take all branches, once each, in any order⬇⬆

STAT2(Stat1,Tyr690~0) <-> STAT2(Stat1,Tyr690~p)

STAT2 Stat1 Tyr690 0 p take all branches, once each, in any order⬇⬆

STAT1(Stat2,Tyr701~p) + STAT2(Stat1,Tyr690~p) -> STAT1(Stat2!1,Tyr701~p).STAT2(Stat1!1,Tyr690~p)

STAT1 ⬇Stat2 Tyr701 p ⬇ STAT2 ⬇Stat1 Tyr690 p

STAT1(Stat2!1,Tyr701~p).STAT2(Stat1!1,Tyr690~p) -> STAT1(Stat2,Tyr701~0) + STAT2(Stat1,Tyr690~0)

STAT1 ⬆Stat2 Tyr701 0 p take one or more branches, once each, in any order⬆ ⬆ STAT2 ⬆Stat1 Tyr690 0 p take one or more branches, once each, in any order⬆

0 -> STAT1_mRNA()

STAT1_mRNA synthesized

0 -> STAT2_mRNA()

STAT2_mRNA synthesized

STAT1_mRNA() -> 0

STAT1_mRNA degraded

STAT2_mRNA() -> 0

STAT2_mRNA degraded

STAT1_mRNA() -> STAT1_mRNA() + STAT1(Stat2,Tyr701~0)

STAT1_mRNA STAT1 Stat2 Tyr701 0 synthesized

STAT2_mRNA() -> STAT2_mRNA() + STAT2(Stat1,Tyr690~0)

STAT2_mRNA STAT2 Stat1 Tyr690 0 synthesized

STAT1(Stat2) -> 0

STAT1 Stat2 Tyr701 0 ?p degraded

STAT2(Stat1) -> 0

STAT2 Stat1 Tyr690 0 ?p degraded

STAT1(Stat2!1).STAT2(Stat1!1) -> 0

STAT1 ⬆Stat2 Tyr701 0 ?p degraded ⬆ STAT2 ⬆Stat1 Tyr690 0 ?p degraded