Molecules MPF(B,DP~U~P,NE~P~U~P2,NE2~U~P,CR~U~P,L~C~N,S~no~Ki~Su)
MPF
B
DP
U
P
NE
P
U
P2
NE2
U
P
CR
U
P
L
C
N
S
no
Ki
Su CDC25(B,L~C~N,S~no~Ph~Su~Sq,SD~U~P,AP~U~P~D,SE~U~P,T~A~B~C)
CDC25
B
L
C
N
S
no
Ph
Su
Sq
SD
U
P
AP
U
P
D
SE
U
P
T
A
B
C WEE1(B,L~N,DP~U~P~M,SP~U~P,S~no~Ki~Su)
WEE1
B
L
N
DP
U
P
M
SP
U
P
S
no
Ki
Su CHK1(B,AP~U~P,S~no~Ki~Su,L~C~N)
CHK1
B
AP
U
P
S
no
Ki
Su
L
C
N CHK2(B,L~C~N,S~no~Ki~Su,AP~U~P)
CHK2
B
L
C
N
S
no
Ki
Su
AP
U
P PLK1(B,L~C~N,S~no~Ki~Su,AP~U~P)
PLK1
B
L
C
N
S
no
Ki
Su
AP
U
P H3(B,L~C~N,S~no~Su,AP~U~P)
H3
B
L
C
N
S
no
Su
AP
U
P Species MPF(B,DP~U,NE~U,NE2~U,CR~P,L~C,S~no)
MPF
B
DP
U
NE
U
NE2
U
CR
P
L
C
S
no CDC25(B,L~N,S~no,SD~U,AP~P,SE~U,T~A)
CDC25
B
L
N
S
no
SD
U
AP
P
SE
U
T
A CDC25(B,L~C,S~no,SD~U,AP~U,SE~U,T~B)
CDC25
B
L
C
S
no
SD
U
AP
U
SE
U
T
B CDC25(B,S~no,SD~U,AP~U,SE~U,T~C,L~C)
CDC25
B
S
no
SD
U
AP
U
SE
U
T
C
L
C WEE1(B,L~N,DP~U,SP~U,S~no)
WEE1
B
L
N
DP
U
SP
U
S
no Observables The observables were set according to each figure. Histone_H3 H3(AP~P)
H3
? B
L
C
? N
S
no
? Su
AP
P Tot_WEE1 WEE1()
WEE1
? B
L
? N
DP
U
P
? M
SP
U
? P
S
no
Ki
? Su Active_WEE1 WEE1(DP~U)
WEE1
? B
L
? N
DP
U
SP
U
? P
S
no
Ki
? Su Super_WEE1 WEE1(SP~P,DP~U)
WEE1
? B
L
? N
DP
U
SP
P
S
no
Ki
? Su Tot_PLK PLK1()
PLK1
? B
L
C
? N
S
no
Ki
? Su
AP
U
? P Ca_PLK PLK1(L~C,AP~P)
PLK1
? B
L
C
S
no
Ki
? Su
AP
P Na_PLK PLK1(L~N,AP~P)
PLK1
? B
L
N
S
no
Ki
? Su
AP
P Active_PLK PLK1(AP~P)
PLK1
? B
L
C
? N
S
no
Ki
? Su
AP
P Tot_CDC25a CDC25(T~A)
CDC25
? B
L
C
? N
S
no
Ph
Su
? Sq
SD
U
? P
AP
U
P
? D
SE
U
? P
T
A A_CDC25a CDC25(T~A,AP~P,S~no)
CDC25
? B
L
C
? N
S
no
SD
U
? P
AP
P
SE
U
? P
T
A seq_CDC25a CDC25(T~A,B!1).E33(B!1,Sq~Y)
CDC25
B
L
C
? N
S
no
Ph
Su
? Sq
SD
U
? P
AP
U
P
? D
SE
U
? P
T
A
E33
B
Sq
Y
S
? no
L
C
? N Na_Cdc25a_N CDC25(T~A,AP~P,S~no,L~N)
CDC25
? B
L
N
S
no
SD
U
? P
AP
P
SE
U
? P
T
A Tot_CDC25b CDC25(T~B)
CDC25
? B
L
C
? N
S
no
Ph
Su
? Sq
SD
U
? P
AP
U
P
? D
SE
U
? P
T
B Act_CDC25b CDC25(T~B,AP~P,S~no)
CDC25
? B
L
C
? N
S
no
SD
U
? P
AP
P
SE
U
? P
T
B seq_CDC25b CDC25(B!1,T~B).E33(B!1,Sq~Y)
CDC25
B
L
C
? N
S
no
Ph
Su
? Sq
SD
U
? P
AP
U
P
? D
SE
U
? P
T
B
E33
B
Sq
Y
S
? no
L
C
? N Na_Cdc25b CDC25(T~B,AP~P,S~no,L~N)
CDC25
? B
L
N
S
no
SD
U
? P
AP
P
SE
U
? P
T
B Ca_CDC25b CDC25(T~B,AP~P,S~no,L~C)
CDC25
? B
L
C
S
no
SD
U
? P
AP
P
SE
U
? P
T
B Tot_CDC25c CDC25(T~C)
CDC25
? B
L
C
? N
S
no
Ph
Su
? Sq
SD
U
? P
AP
U
P
? D
SE
U
? P
T
C Molecules Act_CDC25c CDC25(T~*,AP~P,S~no,L~C) Molecules Act_CDC25c CDC25(AP~P,S~no,L~C) Ca_CDC25c CDC25(T~C,AP~P,S~no,L~C)
CDC25
? B
L
C
S
no
SD
U
? P
AP
P
SE
U
? P
T
C Na_CDC25c CDC25(T~C,AP~P,L~N)
CDC25
? B
L
N
S
no
Ph
Su
? Sq
SD
U
? P
AP
P
SE
U
? P
T
C seq_CDC25c CDC25(B!1,T~C).E33(B!1,Sq~Y)
CDC25
B
L
C
? N
S
no
Ph
Su
? Sq
SD
U
? P
AP
U
P
? D
SE
U
? P
T
C
E33
B
Sq
Y
S
? no
L
C
? N Ca_MPF MPF(L~C,DP~U)
MPF
? B
DP
U
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
C
S
no
Ki
? Su Tot_MPF MPF()
MPF
? B
DP
U
? P
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
C
? N
S
no
Ki
? Su C_MPF MPF(L~C)
MPF
? B
DP
U
? P
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
C
S
no
Ki
? Su N_MPF MPF(L~N)
MPF
? B
DP
U
? P
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
N
S
no
Ki
? Su Na_MPF MPF(L~N,DP~U)
MPF
? B
DP
U
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
N
S
no
Ki
? Su Act_CHK1 CHK1(AP~P,L~C)
CHK1
? B
AP
P
S
no
Ki
? Su
L
C Na_CHK1 CHK1(AP~P,L~N)
CHK1
? B
AP
P
S
no
Ki
? Su
L
N Act_CHK2 CHK2(AP~P,L~C)
CHK2
? B
L
C
S
no
Ki
? Su
AP
P Na_CHK2 CHK2(AP~P,L~N)
CHK2
? B
L
N
S
no
Ki
? Su
AP
P Reaction Rules # PROTEIN CREATION RULES ## DUM(L~C) -> DUM(L~C) + MPF(B,DP~U,NE~U,NE2~U,CR~P,L~C,S~no)
DUM
L
C
MPF
B
DP
U
NE
U
NE2
U
CR
P
L
C
S
no
DUM(L~C) -> DUM(L~C) + CDC25(B,L~C,S~no,SD~U,AP~P,SE~U,T~A)
DUM
L
C
CDC25
B
L
C
S
no
SD
U
AP
P
SE
U
T
A
DUM(L~C) -> DUM(L~C) + CDC25(B,L~C,S~no,SD~U,AP~U,SE~U,T~B)
DUM
L
C
CDC25
B
L
C
S
no
SD
U
AP
U
SE
U
T
B
DUM(L~N) -> DUM(L~N) + CDC25(B,S~no,SD~U,AP~U,SE~U,T~C,L~N)
DUM
L
N
CDC25
B
L
N
S
no
SD
U
AP
U
SE
U
T
C
DUM(L~N) -> DUM(L~N) + WEE1(B,L~N,DP~U,SP~U,S~no)
DUM
L
N
WEE1
B
L
N
DP
U
SP
U
S
no
DUM(L~C) -> DUM(L~C) + MYT1(B,S~no,L~C) # PROTEIN DESTRUCTION RULES ## DUM(L~C) + MPF(B,DP~U~P,S~no) -> DUM(L~C) kMPFout DUM(L~C) + MPF(B,DP,S~no) -> DUM(L~C)
DUM
L
C
MPF
B
DP
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
C
? N
S
no
DUM(L~C) + CDC25(B,S~no) -> DUM(L~C)
DUM
L
C
CDC25
B
L
C
? N
S
no
SD
U
? P
AP
U
P
? D
SE
U
? P
T
A
B
? C
DUM(L~C) + WEE1(B,L~N,S~no) -> DUM(L~C)
DUM
L
C
WEE1
B
L
N
DP
U
P
? M
SP
U
? P
S
no
DUM(L~C) + MYT1(B,S~no,L~C) -> DUM(L~C) # SPONTANEOUS ACTIVATION OF CDC25b ## CDC25(B,L~C,S~no,AP~U,T~B) -> CDC25(B,L~C,S~no,AP~P,T~B)
CDC25
B
L
C
S
no
SD
U
? P
AP
U
P
take all branches, once each, in any order ⬇
SE
U
? P
T
B CDC25(B,L~C,S~no,AP~D,T~B) -> CDC25(B,L~C,S~no,AP~P,T~B)
CDC25
B
L
C
S
no
SD
U
? P
AP
P
D
take one or more branches, once each, in any order ⬆
SE
U
? P
T
B CDC25(B,L~N,S~no,AP~U,T~B) -> CDC25(B,L~N,S~no,AP~P,T~B)
CDC25
B
L
N
S
no
SD
U
? P
AP
U
P
take all branches, once each, in any order ⬇
SE
U
? P
T
B CDC25(B,L~N,S~no,AP~D,T~B) -> CDC25(B,L~N,S~no,AP~P,T~B)
CDC25
B
L
N
S
no
SD
U
? P
AP
P
D
take one or more branches, once each, in any order ⬆
SE
U
? P
T
B # ACTIVATION OF Cdc25b BY CDC25a ## CDC25(B,L~C,S~no,AP~U,T~B) + CDC25(B,L~C,S~no,AP~P,T~A) -> CDC25(B,L~C,S~no,AP~P,T~B) + CDC25(B,L~C,S~no,AP~P,T~A)
CDC25
B
L
C
S
no
SD
U
? P
AP
U
P
take all branches, once each, in any order ⬇
SE
U
? P
T
B
CDC25
B
L
C
S
no
SD
U
? P
AP
P
SE
U
? P
T
A CDC25(B,L~C,S~no,AP~D,T~B) + CDC25(B,L~C,S~no,AP~P,T~A) -> CDC25(B,L~C,S~no,AP~P,T~B) + CDC25(B,L~C,S~no,AP~P,T~A)
CDC25
B
L
C
S
no
SD
U
? P
AP
P
D
take one or more branches, once each, in any order ⬆
SE
U
? P
T
B
CDC25
B
L
C
S
no
SD
U
? P
AP
P
SE
U
? P
T
A CDC25(B,L~N,S~no,AP~U,T~B) + CDC25(B,L~N,S~no,AP~P,T~A) -> CDC25(B,L~N,S~no,AP~P,T~B) + CDC25(B,L~N,S~no,AP~P,T~A)
CDC25
B
L
N
S
no
SD
U
? P
AP
U
P
take all branches, once each, in any order ⬇
SE
U
? P
T
B
CDC25
B
L
N
S
no
SD
U
? P
AP
P
SE
U
? P
T
A CDC25(B,L~N,S~no,AP~D,T~B) + CDC25(B,L~N,S~no,AP~P,T~A) -> CDC25(B,L~N,S~no,AP~P,T~B) + CDC25(B,L~N,S~no,AP~P,T~A)
CDC25
B
L
N
S
no
SD
U
? P
AP
P
D
take one or more branches, once each, in any order ⬆
SE
U
? P
T
B
CDC25
B
L
N
S
no
SD
U
? P
AP
P
SE
U
? P
T
A # ACTIVATION OF MPF BY Cdc25's ## MPF(B,DP~P,S~no,L~C) + CDC25(B,L~C,S~no,AP~P) <-> MPF(B!0,DP~P,S~Su,L~C).CDC25(B!0,L~C,S~Ph,AP~P)
MPF
⬇⬆ B
DP
P
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
C
S
no
Su
take all branches, once each, in any order ⬇ ⬆
⬇⬆
CDC25
⬇⬆ B
L
C
S
no
Ph
take all branches, once each, in any order ⬇ ⬆
SD
U
? P
AP
P
SE
U
? P
T
A
B
? C MPF(B!0,DP~P,S~Su,L~C).CDC25(B!0,L~C,S~Ph,AP~P) -> MPF(B,DP~U,S~no,L~C) + CDC25(B,L~C,S~no,AP~P)
MPF
⬆ B
DP
U
P
take one or more branches, once each, in any order ⬆
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
C
S
no
Su
take one or more branches, once each, in any order ⬆
⬆
CDC25
⬆ B
L
C
S
no
Ph
take one or more branches, once each, in any order ⬆
SD
U
? P
AP
P
SE
U
? P
T
A
B
? C MPF(B,DP~P,S~no,L~N) + CDC25(B,L~N,S~no,AP~P) <-> MPF(B!0,DP~P,S~Su,L~N).CDC25(B!0,S~Ph,AP~P,L~N)
MPF
⬇⬆ B
DP
P
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
N
S
no
Su
take all branches, once each, in any order ⬇ ⬆
⬇⬆
CDC25
⬇⬆ B
L
N
S
no
Ph
take all branches, once each, in any order ⬇ ⬆
SD
U
? P
AP
P
SE
U
? P
T
A
B
? C MPF(B!0,DP~P,S~Su,L~N).CDC25(B!0,S~Ph,AP~P,L~N) -> MPF(B,DP~U,S~no,L~N) + CDC25(B,L~N,S~no,AP~P)
MPF
⬆ B
DP
U
P
take one or more branches, once each, in any order ⬆
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
N
S
no
Su
take one or more branches, once each, in any order ⬆
⬆
CDC25
⬆ B
L
N
S
no
Ph
take one or more branches, once each, in any order ⬆
SD
U
? P
AP
P
SE
U
? P
T
A
B
? C # ACTIVATION OF MPF BY Cdc25c ## MPF(B,DP~P,S~no,L~C) + CDC25(B,L~C,S~no,AP~P,T~C) <-> MPF(B!0,DP~P,S~Su,L~C).CDC25(B!0,L~C,S~Ph,AP~P,T~C)
MPF
⬇⬆ B
DP
P
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
C
S
no
Su
take all branches, once each, in any order ⬇ ⬆
⬇⬆
CDC25
⬇⬆ B
L
C
S
no
Ph
take all branches, once each, in any order ⬇ ⬆
SD
U
? P
AP
P
SE
U
? P
T
C MPF(B!0,DP~P,S~Su,L~C).CDC25(B!0,L~C,S~Ph,AP~P,T~C) -> MPF(B,DP~U,S~no,L~C) + CDC25(B,L~C,S~no,AP~P,T~C)
MPF
⬆ B
DP
U
P
take one or more branches, once each, in any order ⬆
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
C
S
no
Su
take one or more branches, once each, in any order ⬆
⬆
CDC25
⬆ B
L
C
S
no
Ph
take one or more branches, once each, in any order ⬆
SD
U
? P
AP
P
SE
U
? P
T
C MPF(B,DP~P,S~no,L~N) + CDC25(B,L~N,S~no,AP~P,T~C) <-> MPF(B!0,DP~P,S~Su,L~N).CDC25(B!0,S~Ph,AP~P,T~C,L~N)
MPF
⬇⬆ B
DP
P
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
N
S
no
Su
take all branches, once each, in any order ⬇ ⬆
⬇⬆
CDC25
⬇⬆ B
L
N
S
no
Ph
take all branches, once each, in any order ⬇ ⬆
SD
U
? P
AP
P
SE
U
? P
T
C MPF(B!0,DP~P,S~Su,L~N).CDC25(B!0,S~Ph,AP~P,L~N,T~C) -> MPF(B,DP~U,S~no,L~N) + CDC25(B,L~N,S~no,AP~P,T~C)
MPF
⬆ B
DP
U
P
take one or more branches, once each, in any order ⬆
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
N
S
no
Su
take one or more branches, once each, in any order ⬆
⬆
CDC25
⬆ B
L
N
S
no
Ph
take one or more branches, once each, in any order ⬆
SD
U
? P
AP
P
SE
U
? P
T
C # SPONTANEOUS DEACTIVATION OF CDC25's ## CDC25(B,L~C,S~no,T~C,AP~P) + DUM(L~C) -> CDC25(B,L~C,S~no,T~C,AP~U) + DUM(L~C)
CDC25
B
L
C
S
no
SD
U
? P
AP
U
P
take one or more branches, once each, in any order ⬆
SE
U
? P
T
C
DUM
L
C CDC25(B,L~N,S~no,T~C,AP~P) + DUM(L~N) -> CDC25(B,S~no,T~C,AP~U,L~N) + DUM(L~N)
CDC25
B
L
N
S
no
SD
U
? P
AP
U
P
take one or more branches, once each, in any order ⬆
SE
U
? P
T
C
DUM
L
N # DEGRADATION OF SEQUESTERED CDC25's ## CDC25(B!0,L~C,SD~U,S~Sq,SE~P).E33(B!0,Sq~Y,L~C,S~no) -> E33(B,Sq~N,L~C,S~no)
CDC25
⬆ B
L
C
S
Sq
SD
U
AP
U
P
? D
SE
P
T
A
B
? C
⬆
E33
⬆ B
Sq
N
Y
take one or more branches, once each, in any order ⬆
S
no
L
C # ACTIVATION OF Cdc25c BY MPF ## MPF(B,L~N,DP~U,S~no) + CDC25(B,L~N,S~no,AP~U,T~C) <-> MPF(B!0,L~N,DP~U,S~Ki).CDC25(B!0,L~N,S~Su,AP~U,T~C)
MPF
⬇⬆ B
DP
U
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
N
S
no
Ki
take all branches, once each, in any order ⬇ ⬆
⬇⬆
CDC25
⬇⬆ B
L
N
S
no
Su
take all branches, once each, in any order ⬇ ⬆
SD
U
? P
AP
U
SE
U
? P
T
C MPF(B!0,L~N,DP~U,S~Ki).CDC25(B!0,L~N,S~Su,AP~U,T~C) -> MPF(B,L~N,DP~U,S~no) + CDC25(B,L~N,S~no,AP~P,T~C)
MPF
⬆ B
DP
U
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
N
S
no
Ki
take one or more branches, once each, in any order ⬆
⬆
CDC25
⬆ B
L
N
S
no
Su
take one or more branches, once each, in any order ⬆
SD
U
? P
AP
U
P
take all branches, once each, in any order ⬇
SE
U
? P
T
C MPF(B,L~C,DP~U,S~no) + CDC25(B,L~C,S~no,AP~U,T~C) <-> MPF(B!0,L~C,DP~U,S~Ki).CDC25(B!0,L~C,S~Su,AP~U,T~C)
MPF
⬇⬆ B
DP
U
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
C
S
no
Ki
take all branches, once each, in any order ⬇ ⬆
⬇⬆
CDC25
⬇⬆ B
L
C
S
no
Su
take all branches, once each, in any order ⬇ ⬆
SD
U
? P
AP
U
SE
U
? P
T
C MPF(B!0,L~C,DP~U,S~Ki).CDC25(B!0,L~C,S~Su,AP~U,T~C)->MPF(B,L~C,DP~U,S~no)+CDC25(B,L~C,S~no,SD~*,AP~P,T~C) kCDCa MPF(B!0,L~C,DP~U,S~Ki).CDC25(B!0,L~C,S~Su,AP~U,T~C) -> MPF(B,L~C,DP~U,S~no) + CDC25(B,L~C,S~no,AP~P,T~C)
MPF
⬆ B
DP
U
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
C
S
no
Ki
take one or more branches, once each, in any order ⬆
⬆
CDC25
⬆ B
L
C
S
no
Su
take one or more branches, once each, in any order ⬆
SD
U
? P
AP
U
P
take all branches, once each, in any order ⬇
SE
U
? P
T
C # DEACTIVATION OF Wee1 BY MPF ## MPF(B,L~N,DP~U,S~no) + WEE1(B,L~N,DP~U,S~no) <-> MPF(B!0,L~N,DP~U,S~Ki).WEE1(B!0,L~N,DP~U,S~Su)
MPF
⬇⬆ B
DP
U
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
N
S
no
Ki
take all branches, once each, in any order ⬇ ⬆
⬇⬆
WEE1
⬇⬆ B
L
N
DP
U
SP
U
? P
S
no
Su
take all branches, once each, in any order ⬇ ⬆ ⚠️ Molecule order mismatch - skipping reaction: reactants: MPF, WEE1 products: WEE1, MPF # PIN1 Destruction of Wee1 ## PIN1(B,L~N,S~no) + WEE1(B,L~N,DP~P,S~no) -> PIN1(B,L~N,S~no)
PIN1
B
L
N
S
no
WEE1
B
L
N
DP
P
SP
U
? P
S
no
PIN1(B,L~N,S~no) + WEE1(B,L~N,DP~M,S~no) -> PIN1(B,L~N,S~no)
PIN1
B
L
N
S
no
WEE1
B
L
N
DP
M
SP
U
? P
S
no
# DEACTIVATION OF MPF BY WEE1 AND pkMYT1 ## ⚠️ Molecule order mismatch - skipping reaction: reactants: WEE1, MPF products: MPF, WEE1 ⚠️ Molecule order mismatch - skipping reaction: reactants: MPF, WEE1 products: WEE1, MPF ⚠️ Molecule order mismatch - skipping reaction: reactants: WEE1, MPF products: MPF, WEE1 ⚠️ Molecule order mismatch - skipping reaction: reactants: MPF, WEE1 products: WEE1, MPF ⚠️ Molecule order mismatch - skipping reaction: reactants: MYT1, MPF products: MPF, MYT1 ⚠️ Molecule order mismatch - skipping reaction: reactants: MPF, MYT1 products: MYT1, MPF # PHOSPHORYLATION OF MPF CYTOPLASMIC RETENTION SITE BY UNKOWN KINASE ## ⚠️ Molecule order mismatch - skipping reaction: reactants: ProX, MPF products: MPF, ProX ⚠️ Molecule order mismatch - skipping reaction: reactants: MPF, ProX products: ProX, MPF # CHK1 AND CHK2 ENABLING SEQUESTERATION OF CDC25 ## CHK1(B,AP~P,S~no,L~C) + CDC25(B,L~C,S~no,SD~U,SE~U) <-> CHK1(B!0,AP~P,S~Ki,L~C).CDC25(B!0,L~C,SD~U,SE~U,S~Su)
CHK1
⬇⬆ B
AP
P
S
no
Ki
take all branches, once each, in any order ⬇ ⬆
L
C
⬇⬆
CDC25
⬇⬆ B
L
C
S
no
Su
take all branches, once each, in any order ⬇ ⬆
SD
U
AP
U
P
? D
SE
U
T
A
B
? C CHK1(B,AP~P,S~no,L~N) + CDC25(B,L~N,S~no,SD~U,SE~U) <-> CHK1(B!0,AP~P,S~Ki,L~N).CDC25(B!0,L~N,SD~U,SE~U,S~Su)
CHK1
⬇⬆ B
AP
P
S
no
Ki
take all branches, once each, in any order ⬇ ⬆
L
N
⬇⬆
CDC25
⬇⬆ B
L
N
S
no
Su
take all branches, once each, in any order ⬇ ⬆
SD
U
AP
U
P
? D
SE
U
T
A
B
? C CHK1(B!0,AP~P,S~Ki,L~C).CDC25(B!0,L~C,SD~U,SE~U,S~Su) -> CHK1(B,AP~P,S~no,L~C) + CDC25(B,L~C,S~no,SD~U,SE~P)
CHK1
⬆ B
AP
P
S
no
Ki
take one or more branches, once each, in any order ⬆
L
C
⬆
CDC25
⬆ B
L
C
S
no
Su
take one or more branches, once each, in any order ⬆
SD
U
AP
U
P
? D
SE
U
P
take all branches, once each, in any order ⬇
T
A
B
? C CHK1(B!0,AP~P,S~Ki,L~N).CDC25(B!0,L~N,SD~U,SE~U,S~Su) -> CHK1(B,AP~P,S~no,L~N) + CDC25(B,L~N,S~no,SD~U,SE~P)
CHK1
⬆ B
AP
P
S
no
Ki
take one or more branches, once each, in any order ⬆
L
N
⬆
CDC25
⬆ B
L
N
S
no
Su
take one or more branches, once each, in any order ⬆
SD
U
AP
U
P
? D
SE
U
P
take all branches, once each, in any order ⬇
T
A
B
? C CHK2(B,L~C,S~no,AP~P) + CDC25(B,L~C,S~no,SD~U,SE~U) <-> CHK2(B!0,L~C,S~Ki,AP~P).CDC25(B!0,L~C,SD~U,SE~U,S~Su)
CHK2
⬇⬆ B
L
C
S
no
Ki
take all branches, once each, in any order ⬇ ⬆
AP
P
⬇⬆
CDC25
⬇⬆ B
L
C
S
no
Su
take all branches, once each, in any order ⬇ ⬆
SD
U
AP
U
P
? D
SE
U
T
A
B
? C CHK2(B!0,L~C,S~Ki,AP~P).CDC25(B!0,L~C,SD~U,SE~U,S~Su) -> CHK2(B,L~C,S~no,AP~P) + CDC25(B,L~C,S~no,SD~U,SE~P)
CHK2
⬆ B
L
C
S
no
Ki
take one or more branches, once each, in any order ⬆
AP
P
⬆
CDC25
⬆ B
L
C
S
no
Su
take one or more branches, once each, in any order ⬆
SD
U
AP
U
P
? D
SE
U
P
take all branches, once each, in any order ⬇
T
A
B
? C CHK2(B,L~N,S~no,AP~P) + CDC25(B,L~N,S~no,SD~U,SE~U) <-> CHK2(B!0,L~N,S~Ki,AP~P).CDC25(B!0,L~N,SD~U,SE~U,S~Su)
CHK2
⬇⬆ B
L
N
S
no
Ki
take all branches, once each, in any order ⬇ ⬆
AP
P
⬇⬆
CDC25
⬇⬆ B
L
N
S
no
Su
take all branches, once each, in any order ⬇ ⬆
SD
U
AP
U
P
? D
SE
U
T
A
B
? C CHK2(B!0,L~N,S~Ki,AP~P).CDC25(B!0,L~N,SD~U,SE~U,S~Su) -> CHK2(B,L~N,S~no,AP~P) + CDC25(B,L~N,S~no,SD~U,SE~P)
CHK2
⬆ B
L
N
S
no
Ki
take one or more branches, once each, in any order ⬆
AP
P
⬆
CDC25
⬆ B
L
N
S
no
Su
take one or more branches, once each, in any order ⬆
SD
U
AP
U
P
? D
SE
U
P
take all branches, once each, in any order ⬇
T
A
B
? C # SUPERACTIVATION OF Wee1 BY CHK1 ## ⚠️ Molecule order mismatch - skipping reaction: reactants: CHK1, WEE1 products: WEE1, CHK1 ⚠️ Molecule order mismatch - skipping reaction: reactants: WEE1, CHK1 products: CHK1, WEE1 # PP2A REMOVING SEQUESTRATION ENABLING PHOSPHORYLATION FROM CDC25's ## PP2A(B,L~C,S~no) + CDC25(B,L~C,S~no,SE~P) <-> PP2A(B!0,L~C,S~Ph).CDC25(B!0,L~C,S~Su,SE~P)
PP2A
⬇⬆ B
L
C
S
no
Ph
take all branches, once each, in any order ⬇ ⬆
⬇⬆
CDC25
⬇⬆ B
L
C
S
no
Su
take all branches, once each, in any order ⬇ ⬆
SD
U
? P
AP
U
P
? D
SE
P
T
A
B
? C PP2A(B!0,L~C,S~Ph).CDC25(B!0,L~C,S~Su,SE~P) -> PP2A(B,L~C,S~no) + CDC25(B,L~C,S~no,SE~U)
PP2A
⬆ B
L
C
S
no
Ph
take one or more branches, once each, in any order ⬆
⬆
CDC25
⬆ B
L
C
S
no
Su
take one or more branches, once each, in any order ⬆
SD
U
? P
AP
U
P
? D
SE
U
P
take one or more branches, once each, in any order ⬆
T
A
B
? C PP2A(B,L~N,S~no) + CDC25(B,L~N,S~no,SE~P) <-> PP2A(B!0,S~Ph,L~N).CDC25(B!0,L~N,S~Su,SE~P)
PP2A
⬇⬆ B
L
N
S
no
Ph
take all branches, once each, in any order ⬇ ⬆
⬇⬆
CDC25
⬇⬆ B
L
N
S
no
Su
take all branches, once each, in any order ⬇ ⬆
SD
U
? P
AP
U
P
? D
SE
P
T
A
B
? C PP2A(B!0,S~Ph,L~N).CDC25(B!0,L~N,S~Su,SE~P) -> PP2A(B,L~N,S~no) + CDC25(B,L~N,S~no,SE~U)
PP2A
⬆ B
L
N
S
no
Ph
take one or more branches, once each, in any order ⬆
⬆
CDC25
⬆ B
L
N
S
no
Su
take one or more branches, once each, in any order ⬆
SD
U
? P
AP
U
P
? D
SE
U
P
take one or more branches, once each, in any order ⬆
T
A
B
? C # PP2A DISRUPTING 14-3-3 SEQUESTERATION OF CDC25's ## ⚠️ Molecule order mismatch - skipping reaction: reactants: PP2A, CDC25, E33 products: PP2A, E33, CDC25 # PP2A REMOVING THE SEQUESTERATION DISABLING PHOSPHORYLATION FROM CDC25's ## PP2A(B,L~C,S~no) + CDC25(B,L~C,S~no,SD~P) -> PP2A(B,L~C,S~no) + CDC25(B,L~C,S~no,SD~U)
PP2A
B
L
C
S
no
CDC25
B
L
C
S
no
SD
U
P
take one or more branches, once each, in any order ⬆
AP
U
P
? D
SE
U
? P
T
A
B
? C PP2A(B,L~C,S~no) + CDC25(B,L~N,S~no,SD~P) -> PP2A(B,L~C,S~no) + CDC25(B,L~N,S~no,SD~U)
PP2A
B
L
C
S
no
CDC25
B
L
N
S
no
SD
U
P
take one or more branches, once each, in any order ⬆
AP
U
P
? D
SE
U
? P
T
A
B
? C # 14-3-3 SEQUESTERING CDC25's ## ⚠️ Molecule order mismatch - skipping reaction: reactants: E33, CDC25 products: CDC25, E33 ⚠️ Molecule order mismatch - skipping reaction: reactants: E33, CDC25 products: CDC25, E33 CDC25(B!0,L~C,SD~U,S~Sq,SE~P).E33(B!0,L~C,S~no,Sq~N) -> CDC25(B!0,L~C,SD~U,S~Sq,SE~P).E33(B!0,L~C,S~no,Sq~Y)
CDC25
B
L
C
S
Sq
SD
U
AP
U
P
? D
SE
P
T
A
B
? C
E33
B
Sq
N
Y
take all branches, once each, in any order ⬇
S
no
L
C ⚠️ Molecule order mismatch - skipping reaction: reactants: CDC25, E33 products: E33, CDC25 CDC25(B!0,L~N,SD~U,S~Sq,SE~P).E33(B!0,L~N,S~no,Sq~N) -> CDC25(B!0,L~C,SD~U,S~Sq,SE~P).E33(B!0,L~C,S~no,Sq~Y)
CDC25
B
L
C
N
take one or more branches, once each, in any order ⬆
S
Sq
SD
U
AP
U
P
? D
SE
P
T
A
B
? C
E33
B
Sq
N
Y
take all branches, once each, in any order ⬇
S
no
L
C
N
take one or more branches, once each, in any order ⬆ ⚠️ Molecule order mismatch - skipping reaction: reactants: CDC25, E33 products: E33, CDC25 # CHK1 AND CHK2 PHOSPHORYLATION OF CDC25a LEADING TO DEGRADATION ## CHK1(B,AP~P,S~no,L~C) + CDC25(B,L~C,S~no,AP~P,T~A) -> CHK1(B,AP~P,S~no,L~C)
CHK1
B
AP
P
S
no
L
C
CDC25
B
L
C
S
no
SD
U
? P
AP
P
SE
U
? P
T
A
CHK2(B,AP~P,S~no,L~C) + CDC25(B,L~C,S~no,AP~P,T~A) -> CHK2(B,AP~P,S~no,L~C)
CHK2
B
L
C
S
no
AP
P
CDC25
B
L
C
S
no
SD
U
? P
AP
P
SE
U
? P
T
A
CHK1(B,AP~P,S~no,L~N) + CDC25(B,L~N,S~no,AP~P,T~A) -> CHK1(B,AP~P,S~no,L~N)
CHK1
B
AP
P
S
no
L
N
CDC25
B
L
N
S
no
SD
U
? P
AP
P
SE
U
? P
T
A
CHK2(B,AP~P,S~no,L~N) + CDC25(B,L~N,S~no,AP~P,T~A) -> CHK2(B,AP~P,S~no,L~N)
CHK2
B
L
N
S
no
AP
P
CDC25
B
L
N
S
no
SD
U
? P
AP
P
SE
U
? P
T
A
# CHK1 DEACTIVATION OF CDC25b ## ⚠️ Molecule order mismatch - skipping reaction: reactants: CHK1, CDC25 products: CDC25, CHK1 ⚠️ Molecule order mismatch - skipping reaction: reactants: CDC25, CHK1 products: CHK1, CDC25 ⚠️ Molecule order mismatch - skipping reaction: reactants: CHK1, CDC25 products: CDC25, CHK1 ⚠️ Molecule order mismatch - skipping reaction: reactants: CDC25, CHK1 products: CHK1, CDC25 # NUCLEAR IMPORT AND EXPORT RULES ## Importin(L~M) + E33(B,Sq~N,S~no,L~C) -> Importin(L~M) + E33(B,Sq~N,S~no,L~N)
Importin
L
M
CdcFI
Y
? N
E33
B
Sq
N
S
no
L
C
N
take all branches, once each, in any order ⬇ DUM(L~M) + E33(B,Sq~N,S~no,L~N) -> DUM(L~M) + E33(B,Sq~N,S~no,L~C)
DUM
L
M
E33
B
Sq
N
S
no
L
C
N
take one or more branches, once each, in any order ⬆ Importin(L~M) + CHK1(B,S~no,L~C) -> Importin(L~M) + CHK1(B,S~no,L~N)
Importin
L
M
CdcFI
Y
? N
CHK1
B
AP
U
? P
S
no
L
C
N
take all branches, once each, in any order ⬇ DUM(L~M) + CHK1(B,S~no,L~N) -> DUM(L~M) + CHK1(B,S~no,L~C)
DUM
L
M
CHK1
B
AP
U
? P
S
no
L
C
N
take one or more branches, once each, in any order ⬆ Importin(L~M) + CHK2(B,S~no,L~C) -> Importin(L~M) + CHK2(B,S~no,L~N)
Importin
L
M
CdcFI
Y
? N
CHK2
B
L
C
N
take all branches, once each, in any order ⬇
S
no
AP
U
? P DUM(L~M) + CHK2(B,AP~P,S~no,L~N) -> DUM(L~M) + CHK2(B,AP~P,S~no,L~C)
DUM
L
M
CHK2
B
L
C
N
take one or more branches, once each, in any order ⬆
S
no
AP
P Importin(L~M) + CDC25(B,L~C,S~no,T~A) -> Importin(L~M) + CDC25(B,L~N,S~no,T~A)
Importin
L
M
CdcFI
Y
? N
CDC25
B
L
C
N
take all branches, once each, in any order ⬇
S
no
SD
U
? P
AP
U
P
? D
SE
U
? P
T
A Importin(L~M) + CDC25(B,L~C,S~no,T~B) -> Importin(L~M) + CDC25(B,L~N,S~no,T~B)
Importin
L
M
CdcFI
Y
? N
CDC25
B
L
C
N
take all branches, once each, in any order ⬇
S
no
SD
U
? P
AP
U
P
? D
SE
U
? P
T
B CRM1(L~M) + CDC25(B,L~N,S~no,T~A) -> CRM1(L~M) + CDC25(B,L~C,S~no,T~A)
CRM1
L
M
CDC25
B
L
C
N
take one or more branches, once each, in any order ⬆
S
no
SD
U
? P
AP
U
P
? D
SE
U
? P
T
A CRM1(L~M) + CDC25(B,L~N,S~no,T~B) -> CRM1(L~M) + CDC25(B,L~C,S~no,T~B)
CRM1
L
M
CDC25
B
L
C
N
take one or more branches, once each, in any order ⬆
S
no
SD
U
? P
AP
U
P
? D
SE
U
? P
T
B Importin(L~M,CdcFI~N) + CDC25(B,L~C,S~no,T~C) -> Importin(L~M,CdcFI~N) + CDC25(B,L~N,S~no,,T~C)
Importin
L
M
CdcFI
N
CDC25
B
L
C
N
take all branches, once each, in any order ⬇
S
no
SD
U
? P
AP
U
P
? D
SE
U
? P
T
C Importin(L~M,CdcFI~Y) + CDC25(B,L~C,S~no,T~C) -> Importin(L~M,CdcFI~Y) + CDC25(B,L~N,S~no,T~C)
Importin
L
M
CdcFI
Y
CDC25
B
L
C
N
take all branches, once each, in any order ⬇
S
no
SD
U
? P
AP
U
P
? D
SE
U
? P
T
C CRM1(L~M) + CDC25(B,L~N,S~no,T~C,SD~P) -> CRM1(L~M) + CDC25(B,L~C,S~no,T~C,SD~P)
CRM1
L
M
CDC25
B
L
C
N
take one or more branches, once each, in any order ⬆
S
no
SD
P
AP
U
P
? D
SE
U
? P
T
C CRM1(L~M) + CDC25(B,L~N,S~no,T~C,SD~U) -> CRM1(L~M) + CDC25(B,L~C,S~no,T~C,SD~U)
CRM1
L
M
CDC25
B
L
C
N
take one or more branches, once each, in any order ⬆
S
no
SD
U
AP
U
P
? D
SE
U
? P
T
C PLK1(B,L~N,S~no) + CRM1(L~M) -> PLK1(B,L~C,S~no) + CRM1(L~M)
PLK1
B
L
C
N
take one or more branches, once each, in any order ⬆
S
no
AP
U
? P
CRM1
L
M PLK1(B,L~C,S~no) + Importin(L~M) -> PLK1(B,L~N,S~no) + Importin(L~M)
PLK1
B
L
C
N
take all branches, once each, in any order ⬇
S
no
AP
U
? P
Importin
L
M
CdcFI
Y
? N CRM1(L~M) + MPF(B,L~N,NE~U,S~no) -> CRM1(L~M) + MPF(B,L~C,NE~U,S~no)
CRM1
L
M
MPF
B
DP
U
? P
NE
U
NE2
U
? P
CR
U
? P
L
C
N
take one or more branches, once each, in any order ⬆
S
no CRM1(L~M) + MPF(B,L~N,NE~P,S~no) -> CRM1(L~M) + MPF(B,L~C,NE~P,S~no)
CRM1
L
M
MPF
B
DP
U
? P
NE
P
NE2
U
? P
CR
U
? P
L
C
N
take one or more branches, once each, in any order ⬆
S
no Importin(L~M) + MPF(B,L~C,NE~U,NE2~U,CR~P,S~no) -> Importin(L~M) + MPF(B,L~N,NE~U,NE2~U,CR~P,S~no)
Importin
L
M
CdcFI
Y
? N
MPF
B
DP
U
? P
NE
U
NE2
U
CR
P
L
C
N
take all branches, once each, in any order ⬇
S
no Importin(L~M) + MPF(B,L~C,NE~U,NE2~U,CR~U,S~no) -> Importin(L~M) + MPF(B,L~N,NE~U,NE2~U,CR~U,S~no)
Importin
L
M
CdcFI
Y
? N
MPF
B
DP
U
? P
NE
U
NE2
U
CR
U
L
C
N
take all branches, once each, in any order ⬇
S
no Importin(L~M) + MPF(B,L~C,NE2~P,CR~P,S~no) -> Importin(L~M) + MPF(B,L~N,NE2~P,CR~P,S~no)
Importin
L
M
CdcFI
Y
? N
MPF
B
DP
U
? P
NE
P
U
? P2
NE2
P
CR
P
L
C
N
take all branches, once each, in any order ⬇
S
no Importin(L~M) + MPF(B,L~C,NE2~P,CR~U,S~no) -> Importin(L~M) + MPF(B,L~N,NE2~P,CR~U,S~no)
Importin
L
M
CdcFI
Y
? N
MPF
B
DP
U
? P
NE
P
U
? P2
NE2
P
CR
U
L
C
N
take all branches, once each, in any order ⬇
S
no Importin(L~M) + MPF(B,L~C,NE~P,NE2~U,CR~U,S~no) -> Importin(L~M) + MPF(B,L~N,NE~P,NE2~U,CR~U,S~no)
Importin
L
M
CdcFI
Y
? N
MPF
B
DP
U
? P
NE
P
NE2
U
CR
U
L
C
N
take all branches, once each, in any order ⬇
S
no # MODIFICATION OF IMPORTIN FOR FAST TRANSPORT ## Importin(L~M,CdcFI~N) + MPF(B,L~C,DP~U,CR~U,S~no) -> Importin(L~M,CdcFI~Y) + MPF(B,L~C,DP~U,CR~U,S~no)
Importin
L
M
CdcFI
Y
N
take one or more branches, once each, in any order ⬆
MPF
B
DP
U
NE
P
U
? P2
NE2
U
? P
CR
U
L
C
S
no DUM(L~M) + Importin(L~M,CdcFI~Y) -> DUM(L~M) + Importin(L~M,CdcFI~N)
DUM
L
M
Importin
L
M
CdcFI
Y
N
take all branches, once each, in any order ⬇ # CHK1 AND CHK2 SPONTANEOUS DEACTIVATION ## CHK1(B,AP~P,S~no) + DUM(L~C) -> CHK1(B,AP~U,S~no) + DUM(L~C)
CHK1
B
AP
U
P
take one or more branches, once each, in any order ⬆
S
no
L
C
? N
DUM
L
C CHK2(B,S~no,AP~P) + DUM(L~C) -> CHK2(B,S~no,AP~U) + DUM(L~C)
CHK2
B
L
C
? N
S
no
AP
U
P
take one or more branches, once each, in any order ⬆
DUM
L
C # CHK1 AND CHK2 SPONTANEOUS ACTIVATION ## CHK1(B,AP~U,S~no) -> CHK1(B,AP~P,S~no)
CHK1
B
AP
U
P
take all branches, once each, in any order ⬇
S
no
L
C
? N CHK2(B,S~no,AP~U) -> CHK2(B,S~no,AP~P)
CHK2
B
L
C
? N
S
no
AP
U
P
take all branches, once each, in any order ⬇ # REMOVAL OF MPF CYTOPLASMIC RETENTION PHOSPHORYLATION BY CDC25's ## MPF(B,L~C,CR~P,S~no) + CDC25(B,L~C,S~no,AP~P) <-> MPF(B!0,L~C,CR~P,S~Su).CDC25(B!0,L~C,S~Ph,AP~P)
MPF
⬇⬆ B
DP
U
? P
NE
P
U
? P2
NE2
U
? P
CR
P
L
C
S
no
Su
take all branches, once each, in any order ⬇ ⬆
⬇⬆
CDC25
⬇⬆ B
L
C
S
no
Ph
take all branches, once each, in any order ⬇ ⬆
SD
U
? P
AP
P
SE
U
? P
T
A
B
? C MPF(B!0,L~C,CR~P,S~Su).CDC25(B!0,L~C,S~Ph,AP~P) -> MPF(B,L~C,S~no,CR~U) + CDC25(B,L~C,S~no,AP~P)
MPF
⬆ B
DP
U
? P
NE
P
U
? P2
NE2
U
? P
CR
U
P
take one or more branches, once each, in any order ⬆
L
C
S
no
Su
take one or more branches, once each, in any order ⬆
⬆
CDC25
⬆ B
L
C
S
no
Ph
take one or more branches, once each, in any order ⬆
SD
U
? P
AP
P
SE
U
? P
T
A
B
? C # Plk1 RELEASE OF CDC25's SEQUESTERATION ## PLK1(B,L~C,S~no,AP~P) + CDC25(B,L~C,S~no,SD~U) <-> PLK1(B!0,L~C,AP~P,S~Ki).CDC25(B!0,L~C,S~Su,SD~U)
PLK1
⬇⬆ B
L
C
S
no
Ki
take all branches, once each, in any order ⬇ ⬆
AP
P
⬇⬆
CDC25
⬇⬆ B
L
C
S
no
Su
take all branches, once each, in any order ⬇ ⬆
SD
U
AP
U
P
? D
SE
U
? P
T
A
B
? C PLK1(B!0,L~C,S~Ki,AP~P).CDC25(B!0,L~C,SD~U,S~Su) -> PLK1(B,L~C,S~no,AP~P) + CDC25(B,L~C,S~no,SD~P)
PLK1
⬆ B
L
C
S
no
Ki
take one or more branches, once each, in any order ⬆
AP
P
⬆
CDC25
⬆ B
L
C
S
no
Su
take one or more branches, once each, in any order ⬆
SD
U
P
take all branches, once each, in any order ⬇
AP
U
P
? D
SE
U
? P
T
A
B
? C PLK1(B,L~N,S~no,AP~P) + CDC25(B,L~N,S~no,SD~U) <-> PLK1(B!0,L~N,AP~P,S~Ki).CDC25(B!0,L~N,S~Su,SD~U)
PLK1
⬇⬆ B
L
N
S
no
Ki
take all branches, once each, in any order ⬇ ⬆
AP
P
⬇⬆
CDC25
⬇⬆ B
L
N
S
no
Su
take all branches, once each, in any order ⬇ ⬆
SD
U
AP
U
P
? D
SE
U
? P
T
A
B
? C PLK1(B!0,L~N,S~Ki,AP~P).CDC25(B!0,L~N,SD~U,S~Su) -> PLK1(B,L~N,S~no,AP~P) + CDC25(B,L~N,S~no,SD~P)
PLK1
⬆ B
L
N
S
no
Ki
take one or more branches, once each, in any order ⬆
AP
P
⬆
CDC25
⬆ B
L
N
S
no
Su
take one or more branches, once each, in any order ⬆
SD
U
P
take all branches, once each, in any order ⬇
AP
U
P
? D
SE
U
? P
T
A
B
? C ⚠️ Molecule order mismatch - skipping reaction: reactants: PLK1, CDC25, E33 products: PLK1, E33, CDC25 # Plk1 PHOSPHORYLATING MPF ## PLK1(B,L~N,S~no,AP~P) + MPF(B,L~N,S~no,NE~U,NE2~U) <-> PLK1(B!0,L~N,AP~P,S~Ki).MPF(B!0,L~N,NE~U,NE2~U,S~Su)
PLK1
⬇⬆ B
L
N
S
no
Ki
take all branches, once each, in any order ⬇ ⬆
AP
P
⬇⬆
MPF
⬇⬆ B
DP
U
? P
NE
U
NE2
U
CR
U
? P
L
N
S
no
Su
take all branches, once each, in any order ⬇ ⬆ PLK1(B,L~C,S~no,AP~P) + MPF(B,L~C,NE~U,NE2~U,S~no) <-> PLK1(B!0,AP~P,L~C,S~Ki).MPF(B!0,L~C,S~Su,NE~U,NE2~U)
PLK1
⬇⬆ B
L
C
S
no
Ki
take all branches, once each, in any order ⬇ ⬆
AP
P
⬇⬆
MPF
⬇⬆ B
DP
U
? P
NE
U
NE2
U
CR
U
? P
L
C
S
no
Su
take all branches, once each, in any order ⬇ ⬆ PLK1(B,L~N,S~no,AP~P) + MPF(B,L~N,S~no,NE~U,NE2~P) <-> PLK1(B!0,L~N,AP~P,S~Ki).MPF(B!0,L~N,NE~U,NE2~P,S~Su)
PLK1
⬇⬆ B
L
N
S
no
Ki
take all branches, once each, in any order ⬇ ⬆
AP
P
⬇⬆
MPF
⬇⬆ B
DP
U
? P
NE
U
NE2
P
CR
U
? P
L
N
S
no
Su
take all branches, once each, in any order ⬇ ⬆ PLK1(B,L~C,S~no,AP~P) + MPF(B,L~C,NE~U,NE2~P,S~no) <-> PLK1(B!0,AP~P,L~C,S~Ki).MPF(B!0,L~C,S~Su,NE~U,NE2~P)
PLK1
⬇⬆ B
L
C
S
no
Ki
take all branches, once each, in any order ⬇ ⬆
AP
P
⬇⬆
MPF
⬇⬆ B
DP
U
? P
NE
U
NE2
P
CR
U
? P
L
C
S
no
Su
take all branches, once each, in any order ⬇ ⬆ PLK1(B!0,L~C,S~Ki,AP~P).MPF(B!0,L~C,NE~U,S~Su) -> PLK1(B,L~C,S~no,AP~P) + MPF(B,L~C,S~no,NE~P)
PLK1
⬆ B
L
C
S
no
Ki
take one or more branches, once each, in any order ⬆
AP
P
⬆
MPF
⬆ B
DP
U
? P
NE
P
U
take one or more branches, once each, in any order ⬆
NE2
U
? P
CR
U
? P
L
C
S
no
Su
take one or more branches, once each, in any order ⬆ PLK1(B!0,L~N,S~Ki,AP~P).MPF(B!0,L~N,NE~U,S~Su) -> PLK1(B,L~N,S~no,AP~P) + MPF(B,L~N,S~no,NE~P)
PLK1
⬆ B
L
N
S
no
Ki
take one or more branches, once each, in any order ⬆
AP
P
⬆
MPF
⬆ B
DP
U
? P
NE
P
U
take one or more branches, once each, in any order ⬆
NE2
U
? P
CR
U
? P
L
N
S
no
Su
take one or more branches, once each, in any order ⬆ # MPF PHOSPHORYLATING Plk1 ## PLK1(B,L~C,S~no,AP~U) + MPF(B,L~C,S~no,DP~U) <-> PLK1(B!0,L~C,S~Su,AP~U).MPF(B!0,L~C,S~Ki,DP~U)
PLK1
⬇⬆ B
L
C
S
no
Su
take all branches, once each, in any order ⬇ ⬆
AP
U
⬇⬆
MPF
⬇⬆ B
DP
U
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
C
S
no
Ki
take all branches, once each, in any order ⬇ ⬆ PLK1(B,L~N,S~no,AP~U) + MPF(B,L~N,S~no,DP~U) <-> PLK1(B!0,L~N,S~Su,AP~U).MPF(B!0,L~N,S~Ki,DP~U)
PLK1
⬇⬆ B
L
N
S
no
Su
take all branches, once each, in any order ⬇ ⬆
AP
U
⬇⬆
MPF
⬇⬆ B
DP
U
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
N
S
no
Ki
take all branches, once each, in any order ⬇ ⬆ PLK1(B!0,L~N,S~Su,AP~U).MPF(B!0,L~N,S~Ki,DP~U) -> PLK1(B,L~N,S~no,AP~P) + MPF(B,L~N,S~no,DP~U)
PLK1
⬆ B
L
N
S
no
Su
take one or more branches, once each, in any order ⬆
AP
U
P
take all branches, once each, in any order ⬇
⬆
MPF
⬆ B
DP
U
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
N
S
no
Ki
take one or more branches, once each, in any order ⬆ PLK1(B!0,L~C,S~Su,AP~U).MPF(B!0,L~C,S~Ki,DP~U) -> PLK1(B,L~C,S~no,AP~P) + MPF(B,L~C,S~no,DP~U)
PLK1
⬆ B
L
C
S
no
Su
take one or more branches, once each, in any order ⬆
AP
U
P
take all branches, once each, in any order ⬇
⬆
MPF
⬆ B
DP
U
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
C
S
no
Ki
take one or more branches, once each, in any order ⬆ # Plk1 PHOSPHORYLATING CHK1 ## PLK1(B,L~C,S~no,AP~P) + CHK1(B,AP~P,S~no,L~C) -> PLK1(B,L~C,S~no,AP~U) + CHK1(B,AP~P,S~no,L~C)
PLK1
B
L
C
S
no
AP
U
P
take one or more branches, once each, in any order ⬆
CHK1
B
AP
P
S
no
L
C PLK1(B,L~C,S~no,AP~P) + CHK1(B,AP~P,S~no,L~C) -> PLK1(B,L~C,S~no,AP~P) + CHK1(B,AP~U,S~no,L~C)
PLK1
B
L
C
S
no
AP
P
CHK1
B
AP
U
P
take one or more branches, once each, in any order ⬆
S
no
L
C PLK1(B,L~N,S~no,AP~P) + CHK1(B,AP~P,S~no,L~N) -> PLK1(B,S~no,AP~U,L~N) + CHK1(B,AP~P,S~no,L~N)
PLK1
B
L
N
S
no
AP
U
P
take one or more branches, once each, in any order ⬆
CHK1
B
AP
P
S
no
L
N PLK1(B,L~N,S~no,AP~P) + CHK1(B,AP~P,S~no,L~N) -> PLK1(B,S~no,AP~P,L~N) + CHK1(B,AP~U,S~no,L~N)
PLK1
B
L
N
S
no
AP
P
CHK1
B
AP
U
P
take one or more branches, once each, in any order ⬆
S
no
L
N #PLK1 PHOSPHORYLATING WEE1## PLK1(B,L~N,S~no,AP~P) + WEE1(B,L~N,DP~U,S~no) <-> PLK1(B!0,L~N,S~no,AP~P).WEE1(B!0,L~N,DP~U,S~no)
PLK1
⬇⬆ B
L
N
S
no
AP
P
⬇⬆
WEE1
⬇⬆ B
L
N
DP
U
SP
U
? P
S
no PLK1(B!0,L~N,S~no,AP~P).WEE1(B!0,L~N,DP~U,S~no) -> PLK1(B,L~N,S~no,AP~P) + WEE1(B,L~N,DP~P,S~no)
PLK1
⬆ B
L
N
S
no
AP
P
⬆
WEE1
⬆ B
L
N
DP
U
P
take all branches, once each, in any order ⬇
SP
U
? P
S
no PLK1(B,L~N,S~no,AP~P) + WEE1(B,L~N,DP~M,S~no) <-> PLK1(B!0,L~N,S~no,AP~P).WEE1(B!0,L~N,DP~M,S~no)
PLK1
⬇⬆ B
L
N
S
no
AP
P
⬇⬆
WEE1
⬇⬆ B
L
N
DP
M
SP
U
? P
S
no PLK1(B!0,L~N,S~no,AP~P).WEE1(B!0,L~N,DP~M,S~no) -> PLK1(B,L~N,S~no,AP~P) + WEE1(B,L~N,DP~P,S~no)
PLK1
⬆ B
L
N
S
no
AP
P
⬆
WEE1
⬆ B
L
N
DP
P
M
take one or more branches, once each, in any order ⬆
SP
U
? P
S
no # Plk1 PHOSPHORYLATING pkMyt1 ## PLK1(B,L~C,S~no,AP~P) + MYT1(B,S~no,L~C) <-> PLK1(B!0,L~C,AP~P,S~Ki).MYT1(B!0,L~C,S~Su)
PLK1
⬇⬆ B
L
C
S
no
Ki
take all branches, once each, in any order ⬇ ⬆
AP
P
⬇⬆
MYT1
⬇⬆ B
S
no
Su
take all branches, once each, in any order ⬇ ⬆
L
C PLK1(B!0,L~C,AP~P,S~Ki).MYT1(B!0,L~C,S~Su) -> PLK1(B,L~C,S~no,AP~P)
PLK1
⬆ B
L
C
S
no
Ki
take one or more branches, once each, in any order ⬆
AP
P
⬆
MYT1
⬆ B
S
Su
L
C
# MPF AUTOPHOSPHORYLATION ## MPF(B!0,L~N,NE2~U,S~Su).MPF(B!0,L~N,DP~U,S~Ki) -> MPF(B,L~N,S~no,NE2~P) + MPF(B,L~N,DP~U,S~no)
MPF
⬆ B
DP
U
? P
NE
P
U
? P2
NE2
U
P
take all branches, once each, in any order ⬇
CR
U
? P
L
N
S
no
Su
take one or more branches, once each, in any order ⬆
⬆
MPF
⬆ B
DP
U
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
N
S
no
Ki
take one or more branches, once each, in any order ⬆ MPF(B,L~N,S~no,NE2~U) + MPF(B,L~N,DP~U,S~no) <-> MPF(B!0,L~N,NE2~U,S~Su).MPF(B!0,L~N,DP~U,S~Ki)
MPF
⬇⬆ B
DP
U
? P
NE
P
U
? P2
NE2
U
CR
U
? P
L
N
S
no
Su
take all branches, once each, in any order ⬇ ⬆
⬇⬆
MPF
⬇⬆ B
DP
U
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
N
S
no
Ki
take all branches, once each, in any order ⬇ ⬆ MPF(B,L~C,NE2~U,S~no) + MPF(B,L~C,DP~U,S~no) <-> MPF(B!0,L~C,NE2~U,S~Su).MPF(B!0,L~C,DP~U,S~Ki)
MPF
⬇⬆ B
DP
U
? P
NE
P
U
? P2
NE2
U
CR
U
? P
L
C
S
no
Su
take all branches, once each, in any order ⬇ ⬆
⬇⬆
MPF
⬇⬆ B
DP
U
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
C
S
no
Ki
take all branches, once each, in any order ⬇ ⬆ MPF(B!0,L~C,NE2~U,S~Su).MPF(B!0,L~C,DP~U,S~Ki) -> MPF(B,L~C,NE2~P,S~no) + MPF(B,L~C,DP~U,S~no)
MPF
⬆ B
DP
U
? P
NE
P
U
? P2
NE2
U
P
take all branches, once each, in any order ⬇
CR
U
? P
L
C
S
no
Su
take one or more branches, once each, in any order ⬆
⬆
MPF
⬆ B
DP
U
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
C
S
no
Ki
take one or more branches, once each, in any order ⬆ # Phosphorylation of Histone H3 by MPF to Mark Mitotic Entry ## MPF(B,DP~U,L~N,S~no) + H3(B,AP~U,L~N,S~no) <-> MPF(B!0,DP~U,L~N,S~Ki).H3(B!0,AP~U,L~N,S~Su)
MPF
⬇⬆ B
DP
U
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
N
S
no
Ki
take all branches, once each, in any order ⬇ ⬆
⬇⬆
H3
⬇⬆ B
L
N
S
no
Su
take all branches, once each, in any order ⬇ ⬆
AP
U MPF(B!0,DP~U,L~N,S~Ki).H3(B!0,AP~U,L~N,S~Su) -> MPF(B,DP~U,L~N,S~no) + H3(B,AP~P,L~N,S~no)
MPF
⬆ B
DP
U
NE
P
U
? P2
NE2
U
? P
CR
U
? P
L
N
S
no
Ki
take one or more branches, once each, in any order ⬆
⬆
H3
⬆ B
L
N
S
no
Su
take one or more branches, once each, in any order ⬆
AP
U
P
take all branches, once each, in any order ⬇