Molecules

IKK(st~n~a)

IKK st n a

IkBa()

IkBa

IkBa_mRNA()

IkBa_mRNA

A20()

A20

NFkB()

NFkB

Species

IKK(st~n)

IKK st n

IKK(st~a)

IKK st a

IkBa()

IkBa

IkBa_mRNA()

IkBa_mRNA

A20()

A20

NFkB()

NFkB

Observables

IKK(st~a) # neutral/active form of IKK kinase

IKK st a

IkBa_mRNA() # IkBa transcript

IkBa_mRNA

A20() # cytoplasmic A20

A20

NFkB() # nuclear NFkB

NFkB

IkBa() # cytoplasmic, IkB

IkBa

IKK(st~n) # neutral/active form of IKK kinase

IKK st n

Reaction Rules

TNFR1 activation and signal transduction cascade

IKK(st~n) -> IKK(st~a)

IKK st n a take all branches, once each, in any order⬇⬇
A20 synthesis and degradation, IkB transcription, translation, mRNA and protein degradationProtein interactions