Molecules

IKK(st~n~a)

IKK st n a

IkBa()

IkBa

IkBa_mRNA()

IkBa_mRNA

A20()

A20

NFkB()

NFkB

Species

IKK(st~n)

IKK st n

IKK(st~a)

IKK st a

IkBa()

IkBa

IkBa_mRNA()

IkBa_mRNA

A20()

A20

NFkB()

NFkB

Observables

IKK_a IKK(st~a)

IKK st a

tIkBa IkBa_mRNA()

IkBa_mRNA

A20 A20()

A20

NFkB_n NFkB()

NFkB

IkBa IkBa()

IkBa

IKK_n IKK(st~n)

IKK st n

Reaction Rules


TNFR1 activation and signal transduction cascade

IKK(st~n) -> IKK(st~a)

IKK st n a take all branches, once each, in any order⬇

0 -> IKK(st~n)

IKK st n synthesized

IKK(st~a) -> 0

IKK st a degraded

IKK(st~n) -> 0

IKK st n degraded

A20 synthesis and degradation, IkB transcription, translation, mRNA and protein degradation

NFkB() -> NFkB() + A20()

NFkB A20 synthesized

A20() -> 0

A20 degraded

NFkB() -> NFkB() + IkBa_mRNA()

NFkB IkBa_mRNA synthesized

IkBa_mRNA() -> 0

IkBa_mRNA degraded

IkBa_mRNA() -> IkBa_mRNA() + IkBa()

IkBa_mRNA IkBa synthesized

IkBa() -> 0

IkBa degraded

Protein interactions

A20() + IKK(st~a) -> A20()

A20 IKK st a degraded

IKK(st~a) -> IKK(st~a) + NFkB()

IKK st a NFkB synthesized

NFkB() + IkBa() -> 0

NFkB degraded IkBa degraded

IKK(st~a) + IkBa() -> IKK(st~a)

IKK st a IkBa degraded