Molecules

EGFR(ecd,tmd,y1068~u~p,y1173~u~p)

EGFR ecd tmd y1068 u p y1173 u p

EGF(rb)

EGF rb

Grb2(sh2,sos)

Grb2 sh2 sos

Shc(sh3,Y773~p~u)

Shc sh3 Y773 p u

Species

EGF(rb)

EGF rb

EGFR(ecd,tmd,y1068~u,y1173~u)

EGFR ecd tmd y1068 u y1173 u

Shc(sh3,Y773~u)

Shc sh3 Y773 u

Observables

EGFR()

EGFR ecd tmd y1068 u p y1173 u p

EGF()

EGF rb

Shc()

Shc sh3 Y773 p u

EGFR(tmd!+)

EGFR ecd tmd y1068 u p y1173 u p

EGFR(y1068~p!?)

EGFR ecd tmd y1068 p y1173 u p

EGFR(y1173~p!?)

EGFR ecd tmd y1068 u p y1173 p

EGFR(y1068~p!?) @M

EGFR ecd tmd y1068 p y1173 u p

Shc(Y773~p!?)

Shc sh3 Y773 p

Reaction Rules

EGF(rb) + EGFR(ecd,tmd) <-> EGF(rb!1).EGFR(ecd!1,tmd)

EGF 1 ⬆⬇rb EGFR 1 ⬆⬇ecd tmd y1068 u p y1173 u p

EGFR(ecd!+,tmd) + EGFR(ecd!+,tmd) <-> EGFR(ecd!+,tmd!1)%1.EGFR(ecd!+,tmd!1)

EGFR ecd 1 ⬆⬇tmd y1068 u p y1173 u p EGFR ecd 1 ⬆⬇tmd y1068 u p y1173 u p

EGFR(y1173~p) -> EGFR(y1173~u)

EGFR ecd tmd y1068 u p y1173 u p take one or more branches, once each, in any order⬆⬆

EGFR(tmd!+,y1068~u) -> EGFR(tmd!+,y1068~p)

EGFR ecd tmd y1068 u p take all branches, once each, in any order⬇⬇ y1173 u p

EGFR(tmd!+,y1173~u) -> EGFR(tmd!+,y1173~p)

EGFR ecd tmd y1068 u p y1173 u p take all branches, once each, in any order⬇⬇

EGFR(y1068~p) -> EGFR(y1068~u)

EGFR ecd tmd y1068 u p take one or more branches, once each, in any order⬆⬆ y1173 u p

EGFR(y1173~p) + Shc(sh3,Y773~u) <-> EGFR(y1173~p!1).Shc(sh3!1,Y773~u)

EGFR ecd tmd y1068 u p y1173 1 ⬆⬇p Shc 1 ⬆⬇sh3 Y773 u

EGFR(y1173~p!1).Shc(sh3!1,Y773~u) <-> EGFR(y1173~p!1).Shc(sh3!1,Y773~p)

EGFR ecd tmd y1068 u p y1173 1p Shc 1sh3 Y773 p u take one or more branches, once each, in any order⬆⬆

Shc(sh3,Y773~p) -> Shc(sh3,Y773~u)

Shc sh3 Y773 p u take all branches, once each, in any order⬇⬇

EGFR(y1173~p) + Shc(sh3,Y773~p) <-> EGFR(y1173~p!1).Shc(sh3!1,Y773~p)

EGFR ecd tmd y1068 u p y1173 1 ⬆⬇p Shc 1 ⬆⬇sh3 Y773 p