Saved BNGL Diagrams

Molecules

egf(r)

egfr(l,r,Y1068~Y~pY,Y1148~Y~pY)

Shc(PTB,Y317~Y~pY)

Grb2(SH2,SH3)

Sos(dom)

Species

egf(r)

Grb2(SH2,SH3)

Shc(PTB,Y317~Y)

Sos(dom)

egfr(l,r,Y1068~Y,Y1148~Y)

Grb2(SH2,SH3!1).Sos(dom!1)

Observables

Dimers egfr.egfr

Sos_act Shc(PTB!+,Y317~pY!2).Grb2(SH2!2,SH3!3).Sos(dom!3)

Sos_act egfr(Y1068~pY!1).Grb2(SH2!1,SH3!2).Sos(dom!2)

RP egfr(Y1068~pY!?)

RP egfr(Y1148~pY!?)

Shc_Grb Shc(Y317~pY!1).Grb2(SH2!1)

Shc_Grb_Sos Shc(Y317~pY!1).Grb2(SH2!1,SH3!2).Sos(dom!2)

R_Grb2 egfr(Y1068~pY!1).Grb2(SH2!1)

R_Shc egfr(Y1148~pY!1).Shc(PTB!1,Y317~Y)

R_ShcP egfr(Y1148~pY!1).Shc(PTB!1,Y317~pY!?)

ShcP Shc(Y317~pY!?)

R_G_S egfr(Y1068~pY!1).Grb2(SH2!1,SH3!2).Sos(dom!2)

Strong differences are seen for R_G_S in comparison with path model

R_S_G_S egfr(Y1148~pY!1).Shc(PTB!1,Y317~pY!2).Grb2(SH2!2,SH3!3).Sos(dom!3)

Efgr_total egfr

Shc_total Shc

Sos_total Sos

Grb2_total Grb2

Reaction Rules

Ligand-receptor binding

egfr(l,r) + egf(r) <-> egfr(l!1,r).egf(r!1)

Note changed multiplicity
Receptor-aggregation

egfr(l!+,r) + egfr(l!+,r) <-> egfr(l!+,r!3).egfr(l!+,r!3)

Transphosphorylation of egfr by RTK

egfr(r!+,Y1068~Y) -> egfr(r!+,Y1068~pY)

egfr(r!+,Y1148~Y) -> egfr(r!+,Y1148~pY)

Dephosphorylayion

egfr(Y1068~pY) -> egfr(Y1068~Y)

egfr(Y1148~pY) -> egfr(Y1148~Y)

Shc transphosph

egfr(r!+,Y1148~pY!1).Shc(PTB!1,Y317~Y) -> egfr(r!+,Y1148~pY!1).Shc(PTB!1,Y317~pY)

Shc(PTB!+,Y317~pY) -> Shc(PTB!+,Y317~Y)

Y1068 activity

egfr(Y1068~pY) + Grb2(SH2,SH3) <-> egfr(Y1068~pY!1).Grb2(SH2!1,SH3)

egfr(Y1068~pY) + Grb2(SH2,SH3!+) <-> egfr(Y1068~pY!1).Grb2(SH2!1,SH3!+)

egfr(Y1068~pY!1).Grb2(SH2!1,SH3) + Sos(dom) <-> egfr(Y1068~pY!1).Grb2(SH2!1,SH3!2).Sos(dom!2)

Y1148 activity

egfr(Y1148~pY) + Shc(PTB,Y317~Y) <-> egfr(Y1148~pY!1).Shc(PTB!1,Y317~Y)

egfr(Y1148~pY) + Shc(PTB,Y317~pY) <-> egfr(Y1148~pY!1).Shc(PTB!1,Y317~pY)

egfr(Y1148~pY) + Shc(PTB,Y317~pY!1).Grb2(SH2!1,SH3) <-> egfr(Y1148~pY!2).Shc(PTB!2,Y317~pY!1).Grb2(SH2!1,SH3)

egfr(Y1148~pY) + Shc(PTB,Y317~pY!1).Grb2(SH2!1,SH3!3).Sos(dom!3) <-> egfr(Y1148~pY!2).Shc(PTB!2,Y317~pY!1).Grb2(SH2!1,SH3!3).Sos(dom!3)

egfr(Y1148~pY!1).Shc(PTB!1,Y317~pY) + Grb2(SH2,SH3) <-> egfr(Y1148~pY!1).Shc(PTB!1,Y317~pY!2).Grb2(SH2!2,SH3)

egfr(Y1148~pY!1).Shc(PTB!1,Y317~pY) + Grb2(SH2,SH3!3).Sos(dom!3) <-> egfr(Y1148~pY!1).Shc(PTB!1,Y317~pY!2).Grb2(SH2!2,SH3!3).Sos(dom!3)

Shc(PTB!+,Y317~pY!2).Grb2(SH2!2,SH3) + Sos(dom) <-> Shc(PTB!+,Y317~pY!2).Grb2(SH2!2,SH3!3).Sos(dom!3)

Cytosolic

Shc(PTB,Y317~pY) + Grb2(SH2,SH3) <-> Shc(PTB,Y317~pY!1).Grb2(SH2!1,SH3)

Shc(PTB,Y317~pY) + Grb2(SH2,SH3!+) <-> Shc(PTB,Y317~pY!1).Grb2(SH2!1,SH3!+)

Shc(PTB,Y317~pY) -> Shc(PTB,Y317~Y)

Grb2(SH2,SH3) + Sos(dom) <-> Grb2(SH2,SH3!1).Sos(dom!1)

Shc(PTB,Y317~pY!2).Grb2(SH2!2,SH3) + Sos(dom) <-> Shc(PTB,Y317~pY!2).Grb2(SH2!2,SH3!3).Sos(dom!3)